Negative correlation between CSF lactate levels and MoCA scores in male Chinese subjects
Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal...
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| Published in | Psychiatry research Vol. 255; pp. 49 - 51 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.09.2017
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| ISSN | 0165-1781 1872-7123 1872-7123 |
| DOI | 10.1016/j.psychres.2017.05.017 |
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| Abstract | Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects.
•CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects.•No correlation was found between serum lactate levels and MoCA scores.•No correlation was found between serum lactate levels and CSF lactate levels. |
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| AbstractList | Abstract Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects. Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects. •CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects.•No correlation was found between serum lactate levels and MoCA scores.•No correlation was found between serum lactate levels and CSF lactate levels. Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects. Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects.Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the present study, concentrations of lactate in cerebrospinal fluid (CSF) and peripheral blood were measured to investigate the association of lactate with cognitive ability, which was assessed by Montreal Cognitive Assessment (MoCA), in 99 male Chinese subjects. Correlation analyses revealed that serum lactate levels were negatively correlated with age, and CSF lactate levels were negatively correlated with MoCA scores after Box-Cox transformations. But no correlation was found between serum lactate levels and MoCA scores after Box-Cox transformations. In conclusion, the results indicate that CSF lactate levels were negatively correlated with MoCA scores in male Chinese subjects. |
| Author | Chen, Suling Liu, Yanlong Wang, Haijun Wang, Meiling Tan, Xiaohua Li, Hui Xu, Jinzhong Yang, Xiaoyu Wang, Fan |
| Author_xml | – sequence: 1 givenname: Haijun surname: Wang fullname: Wang, Haijun organization: Department of Pathology, Xinxiang Medical University, Xinxiang 453003, China – sequence: 2 givenname: Xiaohua surname: Tan fullname: Tan, Xiaohua organization: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China – sequence: 3 givenname: Jinzhong surname: Xu fullname: Xu, Jinzhong organization: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China – sequence: 4 givenname: Hui surname: Li fullname: Li, Hui organization: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China – sequence: 5 givenname: Meiling surname: Wang fullname: Wang, Meiling organization: Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China – sequence: 6 givenname: Suling surname: Chen fullname: Chen, Suling organization: The Seventh People's Hospital of Wenzhou, Wenzhou 325005, China – sequence: 7 givenname: Xiaoyu surname: Yang fullname: Yang, Xiaoyu organization: Beijing Jishuitan Hospital, Beijing 100035, China – sequence: 8 givenname: Yanlong surname: Liu fullname: Liu, Yanlong email: benjaminlyl@wmu.edu.cn organization: College of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China – sequence: 9 givenname: Fan surname: Wang fullname: Wang, Fan email: FanWang@bjmu.edu.cn organization: Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100035, China |
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| Cites_doi | 10.1016/0304-3940(95)12058-C 10.1056/NEJMra1309483 10.1016/j.ejpn.2015.09.008 10.3390/ijms17091450 10.1212/WNL.54.3.735 10.1016/j.jcma.2011.05.006 10.1176/ajp.149.10.1369 10.1164/arrd.1984.129.2P2.S35 10.1016/j.braindev.2011.08.004 10.1016/j.pnpbp.2005.01.017 10.1002/jnr.20336 10.1007/s40257-016-0187-3 10.1136/jnnp-2014-308577 10.1385/NMM:5:2:147 |
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| SubjectTerms | Adult Asian Continental Ancestry Group - psychology China Cognition Cognition - physiology CSF Humans Lactate Lactic Acid - blood Lactic Acid - cerebrospinal fluid Male Mental Status and Dementia Tests Psychiatry |
| Title | Negative correlation between CSF lactate levels and MoCA scores in male Chinese subjects |
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