Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer

• Published in: International journal of molecular sciences Vol. 22; no. 5; p. 2402
• Main Authors: Wang, Hui-Ching, Chan, Leong-Perng, Wu, Chun-Chieh, Chang, Shu-Jyuan, Moi, Sin-Hua, Luo, Chi-Wen, Pan, Mei-Ren
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.02.2021; MDPI
• Subjects: Abnormalities; Aneuploidy; Base excision repair; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - secondary; Cell cycle; cell cycles; Cell growth; Cell Proliferation; Chemotherapy; Cyclin-dependent kinases; Deoxyribonucleic acid; Depletion; DNA; DNA damage; DNA polymerase; DNA Polymerase beta - antagonists & inhibitors; DNA Polymerase beta - genetics; DNA Polymerase beta - metabolism; DNA polymerase β; DNA repair; DNA-directed DNA polymerase; Female; Follow-Up Studies; Genes; Genomic instability; Head & neck cancer; Human papillomavirus; Humans; Kinases; Lymph nodes; Lymphatic Metastasis; Lymphatic system; Male; Medical prognosis; Metabolism; Metastases; Metastasis; Middle Aged; Mitosis; Mouth Neoplasms - enzymology; Mouth Neoplasms - genetics; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mutation; Oral cancer; Patients; Prognosis; Proteins; Radiation therapy; Regression analysis; Stability; Stability analysis; Survival; Survival analysis; Survival Rate; Tumor Cells, Cultured; Tumorigenesis; aneuploidy; DNA polymerase β; cell cycles; oral cancer

Most patients with oral squamous cell cancer (OSCC) have a locally advanced stage at diagnosis. The treatment strategies are diverse, including surgery, radiotherapy and chemotherapy. Despite multimodality treatment, the response rate is unsatisfactory. DNA repair and genetic instability are highly...