Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice

• Published in: The Journal of experimental medicine Vol. 214; no. 8; pp. 2303 - 2313
• Main Authors: Cao, Bin, Parnell, Lindsay A., Diamond, Michael S., Mysorekar, Indira U.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 07.08.2017; The Rockefeller University Press
• Subjects: Animals; Autophagy; Autophagy - drug effects; Autophagy - physiology; Disease transmission; Female; Fetuses; Flavivirus; Hydroxychloroquine; Hydroxychloroquine - pharmacology; Infections; Infectious Disease Transmission, Vertical - prevention & control; Infectivity; Inhibition; Mice; Mice, Inbred C57BL; Microencephaly; Phagocytosis; Pharmacology; Placenta; Placenta - physiology; Placenta - virology; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; Therapeutic applications; Trophoblasts; Trophoblasts - physiology; Trophoblasts - virology; Vector-borne diseases; Viruses; Zika Virus; Zika Virus Infection - transmission

Zika virus (ZIKV) infection during pregnancy leads to devastating fetal outcomes, including intrauterine growth restriction and microcephaly. Greater understanding of mechanisms underlying ZIKV maternal-fetal transmission is needed to develop new therapeutic interventions. Here, we define an importa...