From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-κB, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers

• Published in: International journal of molecular sciences Vol. 21; no. 14; p. 4952
• Main Authors: Pereira Beserra, Fernando, Sérgio Gushiken, Lucas Fernando, Vieira, Ana Júlia, Augusto Bérgamo, Danilo, Luísa Bérgamo, Patrícia, Oliveira de Souza, Mariana, Alberto Hussni, Carlos, Kiomi Takahira, Regina, Henrique Nóbrega, Rafael, Monteiro Martinez, Emanuel Ricardo, John Jackson, Christopher, Lemos de Azevedo Maia, Gabriela, Leite Rozza, Ariane, Helena Pellizzon, Cláudia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.07.2020; MDPI
• Subjects: Administration, Cutaneous; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antidiabetics; Antioxidants; Blood vessels; Collagen; Collagen - metabolism; cutaneous wound healing; Cytokines; Cytokines - metabolism; Dermatologic Agents - administration & dosage; Dermatologic Agents - pharmacology; Dermatologic Agents - therapeutic use; Diabetes mellitus; Edema; Enzyme-linked immunosorbent assay; Epidermal growth factor; Fibers; Gene expression; Gene Expression Regulation - drug effects; Growth factors; IL-1β; In vivo methods and tests; Inflammation; Injury analysis; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Interleukin 10; Interleukin 6; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Levels; Lumbar region; lupeol; Male; natural product; Neovascularization, Physiologic - drug effects; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Pentacyclic Triterpenes - administration & dosage; Pentacyclic Triterpenes - pharmacology; Pentacyclic Triterpenes - therapeutic use; Phytotherapy; Rats; Rats, Wistar; Regeneration - drug effects; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Skin; Skin Physiological Phenomena - drug effects; skin regeneration; Tissue engineering; Topical application; Transforming growth factor-b1; triterpene; Tumor necrosis factor-α; Vascular endothelial growth factor; Wound healing; Wound Healing - drug effects; cutaneous wound healing; triterpene; lupeol; natural product; skin regeneration

Skin wound healing is a highly complex event that involves different mediators at the cellular and molecular level. Lupeol has been reported to possess different biological activities, such as anti-inflammatory, antioxidant, antidiabetic, and in vitro wound healing properties, which motivated us to...