Pressure Loading Induces DNA Damage in Human Hepatocyte Line L02 Cells via the ERK1/2-Dicer Signaling Pathway

• Published in: International journal of molecular sciences Vol. 23; no. 10; p. 5342
• Main Authors: Tang, Yanping, Fan, Yanan, Luo, Qing, Song, Guanbin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.05.2022; MDPI
• Subjects: Apoptosis; Cell cycle; Compressive properties; compressive stress; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; ERK1/2–Dicer signal; Extracellular signal-regulated kinase; Gene expression; Hepatocellular carcinoma; hepatocyte; Hepatocytes; Kinases; Liver; Liver cancer; Liver diseases; Microenvironments; Mutation; Phosphorylation; Pressure; Pressure effects; Proteins; Signal transduction; Stem cells; ERK1/2–Dicer signal; hepatocyte; DNA damage; compressive stress

Alteration of liver tissue mechanical microenvironment is proven to be a key factor for causing hepatocyte injury and even triggering the occurrence of hepatocellular carcinoma; however, the underlying mechanisms involved are not fully understood. In this study, using a customized, pressure-loading...