Overexpression of BQ323636.1 Modulated AR/IL-8/CXCR1 Axis to Confer Tamoxifen Resistance in ER-Positive Breast Cancer

• Published in: Life (Basel, Switzerland) Vol. 12; no. 1; p. 93
• Main Authors: Tsoi, Ho, Shi, Ling, Leung, Man-Hong, Man, Ellen, So, Zi-Qing, Chan, Wing-Lok, Khoo, Ui-Soon
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2022; MDPI
• Subjects: AKT protein; Alternative splicing; androgen receptor; Androgen receptors; BQ323636.1; Breast cancer; CXCR1; Cytokines; Estrogen receptors; Estrogens; Ethanol; Gene expression; Interleukin 8; Ligands; Mutation; Plasmids; Proteins; Receptors; RNA polymerase; Signaling; Tamoxifen; tamoxifen resistance; Transcription; St Louis Missouri; United States > US; breast cancer; androgen receptor; tamoxifen resistance; CXCR1; interleukin-8; BQ323636.1

NCOR2 is a co-repressor for estrogen receptor (ER) and androgen receptor (AR). Our group previously identified a novel splice variant of NCOR2, BQ323636.1 (BQ), that mediates tamoxifen resistance via interference of NCOR2 repression on ER. Luciferase reporter assay showed BQ overexpression could enh...