Evolution of Influenza A Virus by Mutation and Re-Assortment
Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of...
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| Published in | International journal of molecular sciences Vol. 18; no. 8; p. 1650 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
07.08.2017
MDPI |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves. |
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| AbstractList | Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves. Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves.Influenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves. |
| Author | Shao, Wenhan Chen, Ji-Long Li, Xinxin Wang, Song Goraya, Mohsan |
| AuthorAffiliation | 2 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China 1 Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; ssjwen@outlook.com (W.S.); xinxinlfjfz@163.com (X.L.); goraya_uaf@yahoo.com (M.U.G.) |
| AuthorAffiliation_xml | – name: 1 Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; ssjwen@outlook.com (W.S.); xinxinlfjfz@163.com (X.L.); goraya_uaf@yahoo.com (M.U.G.) – name: 2 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
| Author_xml | – sequence: 1 givenname: Wenhan surname: Shao fullname: Shao, Wenhan – sequence: 2 givenname: Xinxin surname: Li fullname: Li, Xinxin – sequence: 3 givenname: Mohsan orcidid: 0000-0001-6501-0662 surname: Goraya fullname: Goraya, Mohsan – sequence: 4 givenname: Song surname: Wang fullname: Wang, Song – sequence: 5 givenname: Ji-Long surname: Chen fullname: Chen, Ji-Long |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28783091$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.ejphar.2017.05.038 10.3810/pgm.2009.09.2051 10.1002/embj.201387442 10.1073/pnas.0911915106 10.1371/journal.ppat.1001034 10.3389/fmicb.2013.00151 10.1038/nrd2175 10.3201/eid2006.140233 10.1093/molbev/msl102 10.1016/j.jfma.2017.02.011 10.1093/infdis/jir352 10.1128/JVI.02439-15 10.1098/rstb.2001.0998 10.1073/pnas.0807142105 10.1016/j.virol.2008.07.014 10.2147/IDR.S105473 10.1016/0092-8674(81)90208-7 10.1016/j.vaccine.2009.01.016 10.3201/eid2004.131295 10.1016/j.virusres.2004.02.034 10.1128/JVI.03052-15 10.1099/vir.0.041228-0 10.1371/journal.ppat.1003657 10.3201/eid2304.161866 10.1046/j.1365-2672.2001.01492.x 10.1038/srep23746 10.1016/j.virusres.2006.09.013 10.3201/eid2302.161252 10.1146/annurev.med.51.1.407 10.1016/S0092-8674(00)81771-7 10.1128/JVI.01785-09 10.1038/nrmicro2613 10.1007/s10822-016-9981-5 10.1186/1471-2334-14-480 10.1038/srep33334 10.1017/S1466252307001272 10.1016/j.cmi.2016.07.007 10.1016/j.micinf.2005.12.008 10.1006/viro.1993.1155 10.1056/NEJMra1002842 10.1056/NEJMp0904572 10.1016/0042-6822(91)90588-3 10.1371/journal.ppat.1005583 10.1099/vir.0.19302-0 10.1016/S0140-6736(03)14854-4 10.1128/JVI.01175-13 10.1038/srep26787 10.1002/wrna.1321 10.1038/s41598-017-02598-z 10.1128/jvi.69.2.1099-1106.1995 10.1016/j.antiviral.2016.01.012 10.1007/s13238-015-0191-z 10.1038/nature14348 10.1146/annurev-immunol-032713-120231 10.1016/S0140-6736(14)60111-2 10.1038/nri3665 10.1111/nyas.12462 10.4049/jimmunol.0804198 10.1126/science.1236787 10.1056/NEJMoa1304459 10.20506/rst.28.1.1879 10.1086/502973 10.1371/journal.pone.0046183 10.1038/nature12372 10.1371/journal.ppat.1003845 10.1016/j.jinf.2011.04.013 10.1371/journal.ppat.1006390 10.1016/S0753-3322(00)89026-5 10.1017/S1466252310000071 10.1016/S1473-3099(17)30323-7 10.1056/NEJMoa0903810 10.1586/14760584.2013.824709 10.1016/j.ijid.2016.01.002 10.1126/science.1242917 10.3201/eid2308.170143 10.1128/JVI.06203-11 10.1016/j.vaccine.2007.07.027 10.3390/v4091438 10.1038/srep43566 10.1038/nsmb.1909 10.1016/S0753-3322(00)89025-3 10.1016/j.chom.2010.05.009 10.1006/viro.1994.1555 10.3201/eid1004.030396 10.1038/nature06945 10.1126/science.1069132 10.1007/s11427-009-0062-z 10.1038/srep03058 10.1016/j.vaccine.2007.08.042 10.1128/JVI.00126-14 10.1038/nature03063 10.1099/vir.0.19277-0 10.1126/science.1222213 10.1098/rstb.2001.0999 10.1099/vir.0.82120-0 10.3390/v5102424 10.1016/S0140-6736(13)60903-4 10.3389/fmicb.2017.00741 10.1186/s13567-017-0435-4 |
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| Keywords | virus-host interaction mutation re-assortment influenza A virus |
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| References | ref_93 Li (ref_63) 2017; 7 Li (ref_77) 2017; 23 Fan (ref_54) 2012; 93 Barman (ref_76) 2017; 23 Yoon (ref_88) 2014; 385 Chen (ref_92) 2013; 381 Iwasaki (ref_32) 2014; 14 Goraya (ref_36) 2015; 6 Yang (ref_65) 2017; 116 Rambaut (ref_90) 2008; 453 Potter (ref_7) 2001; 91 Brown (ref_20) 2000; 54 Dawood (ref_71) 2009; 360 Jhung (ref_78) 2015; 64 Carrat (ref_47) 2007; 25 Rimmelzwaan (ref_55) 2009; 27 Schneider (ref_33) 2014; 32 Webster (ref_102) 2014; 1323 Fouchier (ref_18) 2014; 33 Ma (ref_43) 2008; 3 Chare (ref_83) 2003; 84 Phanich (ref_52) 2016; 30 Mwangi (ref_105) 2016; 6 Gao (ref_61) 2013; 368 Shi (ref_94) 2013; 342 Wang (ref_104) 2016; 6 Chen (ref_19) 1998; 95 Mehle (ref_46) 2012; 86 Liu (ref_22) 1995; 69 Bertran (ref_79) 2017; 48 ref_74 Taubenberger (ref_44) 2010; 7 He (ref_84) 2008; 380 Schmolke (ref_37) 2009; 183 Wang (ref_35) 2014; 88 Ohuchi (ref_23) 2006; 8 Lee (ref_75) 2014; 20 Orlich (ref_81) 1994; 204 Taubenberger (ref_89) 2009; 28 Reid (ref_67) 2003; 84 Russell (ref_15) 2008; 105 Zhang (ref_41) 2013; 340 Peng (ref_9) 2017; 7 Forrest (ref_1) 2010; 11 Fischer (ref_97) 2017; 809 Kreijtz (ref_56) 2016; 90 Lee (ref_73) 2017; 23 Kreijtz (ref_58) 2012; 4 Li (ref_31) 2015; 43 Gong (ref_38) 2011; 204 Lam (ref_95) 2015; 522 ref_60 Ahlquist (ref_39) 2002; 296 Matsuzaki (ref_2) 2006; 193 Herz (ref_28) 1981; 26 McAuley (ref_66) 2010; 84 Kuszewski (ref_5) 2000; 54 Gaymard (ref_26) 2016; 22 Zaraket (ref_50) 2013; 87 ref_64 Hay (ref_3) 2001; 356 Dortmans (ref_48) 2013; 3 Hannoun (ref_98) 2013; 12 Kayali (ref_96) 2014; 20 Liu (ref_25) 2009; 52 Castrucci (ref_42) 1993; 193 Rubio (ref_85) 2013; 4 Hutchinson (ref_29) 2013; 5 Vergaraalert (ref_69) 2014; 45 Lambert (ref_99) 2010; 363 Li (ref_24) 2010; 17 Mehle (ref_59) 2009; 106 Scalera (ref_91) 2009; 121 Xiong (ref_49) 2013; 499 Medina (ref_14) 2011; 9 ref_34 Wu (ref_80) 2017; 8 Mills (ref_6) 2004; 432 Cox (ref_12) 2000; 51 Webster (ref_45) 1992; 56 (ref_68) 2006; 5 Chen (ref_40) 2006; 23 Tong (ref_16) 2013; 9 Chen (ref_86) 2016; 43 Schrauwen (ref_51) 2016; 90 Landolt (ref_70) 2007; 8 Couch (ref_100) 2007; 25 Berkhoff (ref_57) 2007; 88 Hussain (ref_101) 2017; 10 Potter (ref_4) 2011; 63 Nicholson (ref_17) 2003; 362 Trifonov (ref_72) 2009; 361 Ouyang (ref_30) 2016; 7 Woolthuis (ref_53) 2016; 6 Jagger (ref_11) 2012; 337 Boulo (ref_27) 2007; 124 Chen (ref_62) 2014; 383 ref_8 Aoyama (ref_13) 1991; 182 Suarez (ref_82) 2004; 10 Gibbs (ref_87) 2001; 356 Fry (ref_103) 2016; 129 Gubareva (ref_21) 2004; 103 Wang (ref_10) 2017; 17 14643124 - Lancet. 2003 Nov 22;362(9397):1733-45 17719149 - Vaccine. 2007 Sep 28;25(39-40):6852-62 19004788 - Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41 24009358 - Science. 2013 Oct 11;342(6155):243-7 26537686 - J Virol. 2015 Nov 04;90(2):1009-22 20700447 - PLoS Pathog. 2010 Aug 05;6(8):e1001034 24130481 - PLoS Pathog. 2013;9(10):e1003657 28583578 - Lancet Infect Dis. 2017 Aug;17 (8):822-832 8438586 - Virology. 1993 Mar;193(1):503-6 17251571 - J Gen Virol. 2007 Feb;88(Pt 2):530-5 17692139 - Anim Health Res Rev. 2007 Jun;8(1):1-21 28262734 - Sci Rep. 2017 Mar 06;7:43566 19618626 - Rev Sci Tech. 2009 Apr;28(1):187-202 12917448 - J Gen Virol. 2003 Sep;84(Pt 9):2285-92 19995968 - Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6 28169827 - Emerg Infect Dis. 2017 Apr;23 (4):637-641 22090127 - J Virol. 2012 Feb;86(3):1750-7 25762140 - Nature. 2015 Jun 4;522(7554):102-5 7326745 - Cell. 1981 Nov;26(3 Pt 1):391-400 23641058 - Science. 2013 Jun 21;340(6139):1463-7 26792744 - J Virol. 2016 Jan 20;90(7):3794-9 21632115 - J Infect. 2011 Oct;63(4):252-9 23623390 - Lancet. 2013 Jun 1;381(9881):1916-25 10872717 - Biomed Pharmacother. 2000 May;54(4):188-95 19840674 - Vaccine. 2009 Oct 23;27(45):6363-5 26490959 - Nucleic Acids Res. 2015 Dec 2;43(21):10321-37 20852645 - Nat Struct Mol Biol. 2010 Oct;17(10):1266-8 24104053 - Viruses. 2013 Oct 02;5(10):2424-46 21083388 - N Engl J Med. 2010 Nov 18;363(21):2036-44 23824818 - J Virol. 2013 Sep;87(17):9911-22 20591210 - Anim Health Res Rev. 2010 Jun;11(1):3-18 10872718 - Biomed Pharmacother. 2000 May;54(4):196-209 24668228 - EMBO J. 2014 Apr 16;33(8):823-41 24391501 - PLoS Pathog. 2014 Jan;10 (1):e1003845 19786538 - J Immunol. 2009 Oct 15;183(8):5180-9 24507376 - Lancet. 2014 Feb 22;383(9918):714-21 8091680 - Virology. 1994 Oct;204(1):462-5 18721995 - Virology. 2008 Oct 10;380(1):12-20 28259506 - J Formos Med Assoc. 2017 Mar;116(3):210-212 19820273 - Postgrad Med. 2009 Sep;121(5):43-7 13679603 - J Gen Virol. 2003 Oct;84(Pt 10):2691-703 11779383 - Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1845-55 1579108 - Microbiol Rev. 1992 Mar;56(1):152-79 17913310 - Vaccine. 2007 Nov 1;25(44):7656-63 22302878 - J Gen Virol. 2012 May;93(Pt 5):987-97 27629812 - Sci Rep. 2016 Sep 15;6:33334 24655395 - Emerg Infect Dis. 2014 Apr;20(4):542-51 28539661 - Sci Rep. 2017 May 24;7(1):2352 28487690 - Front Microbiol. 2017 Apr 25;8:741 24829357 - J Virol. 2014 Aug;88(15):8375-85 28592320 - Vet Res. 2017 Jun 7;48(1):33 26206138 - Protein Cell. 2015 Oct;6(10):712-21 17139286 - Nat Rev Drug Discov. 2006 Dec;5(12):1015-25 28458567 - Infect Drug Resist. 2017 Apr 20;10 :121-134 24990620 - Curr Top Microbiol Immunol. 2014;385:359-75 21791661 - J Infect Dis. 2011 Aug 15;204(4):592-600 21747392 - Nat Rev Microbiol. 2011 Jul 11;9(8):590-603 24762827 - Nat Rev Immunol. 2014 May;14(5):315-28 26778522 - Int J Infect Dis. 2016 Feb;43:85-9 9814710 - Cell. 1998 Oct 30;95(3):409-17 16586359 - J Infect Dis. 2006 May 1;193(9):1229-35 27875109 - Emerg Infect Dis. 2017 Feb;23 (2):359-360 23787694 - Nature. 2013 Jul 25;499(7459):496-9 25654614 - MMWR Morb Mortal Wkly Rep. 2015 Feb 6;64(4):111 28533172 - Eur J Pharmacol. 2017 Aug 15;809:178-190 24024871 - Expert Rev Vaccines. 2013 Sep;12(9):1085-94 2024485 - Virology. 1991 Jun;182(2):475-85 17081640 - Virus Res. 2007 Mar;124(1-2):12-21 22745253 - Science. 2012 Jul 13;337(6091):199-204 20542248 - Cell Host Microbe. 2010 Jun 25;7(6):440-51 27097026 - PLoS Pathog. 2016 Apr 20;12(4):e1005583 18418375 - Nature. 2008 May 29;453(7195):615-9 19565018 - J Mol Genet Med. 2008 Nov 27;3(1):158-66 28609260 - Emerg Infect Dis. 2017 Aug;23 (8):1368-1371 16682242 - Microbes Infect. 2006 Apr;8(5):1287-93 26667656 - Wiley Interdiscip Rev RNA. 2016 Jan-Feb;7(1):129-43 24460592 - Vet Res. 2014 Jan 25;45:7 24555472 - Annu Rev Immunol. 2014;32:513-45 15602562 - Nature. 2004 Dec 16;432(7019):904-6 12016304 - Science. 2002 May 17;296(5571):1270-3 7815489 - J Virol. 1995 Feb;69(2):1099-106 11576290 - J Appl Microbiol. 2001 Oct;91(4):572-9 23577628 - N Engl J Med. 2013 May 16;368(20):1888-97 16945980 - Mol Biol Evol. 2006 Dec;23(12):2336-41 19423869 - N Engl J Med. 2009 Jun 18;360(25):2605-15 19474418 - N Engl J Med. 2009 Jul 9;361(2):115-9 25186370 - BMC Infect Dis. 2014 Sep 04;14:480 15163510 - Virus Res. 2004 Jul;103(1-2):199-203 19471865 - Sci China C Life Sci. 2009 May;52(5):428-38 23805130 - Front Microbiol. 2013 Jun 26;4:151 27279280 - Sci Rep. 2016 Jun 09;6:26787 15200862 - Emerg Infect Dis. 2004 Apr;10(4):693-9 27033724 - Sci Rep. 2016 Apr 01;6:23746 28617868 - PLoS Pathog. 2017 Jun 15;13(6):e1006390 24162312 - Sci Rep. 2013 Oct 28;3:3058 26872862 - Antiviral Res. 2016 May;129:21-38 23049973 - PLoS One. 2012;7(9):e46183 11779385 - Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1861-70 10774473 - Annu Rev Med. 2000;51:407-21 24891213 - Ann N Y Acad Sci. 2014 Sep;1323:115-39 27424943 - Clin Microbiol Infect. 2016 Dec;22(12 ):975-983 19828614 - J Virol. 2010 Jan;84(1):558-64 23170167 - Viruses. 2012 Sep;4(9):1438-76 24856098 - Emerg Infect Dis. 2014 Jun;20(6):1087-9 27714494 - J Comput Aided Mol Des. 2016 Oct;30(10 ):917-926 |
| References_xml | – volume: 809 start-page: 178 year: 2017 ident: ref_97 article-title: New drug-strategies to tackle viral-host interactions for the treatment of influenza virus infections publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2017.05.038 – volume: 121 start-page: 43 year: 2009 ident: ref_91 article-title: The first pandemic of the 21st century: A review of the 2009 pandemic variant influenza A (H1N1) virus publication-title: Postgrad. Med. doi: 10.3810/pgm.2009.09.2051 – volume: 33 start-page: 823 year: 2014 ident: ref_18 article-title: Role of receptor binding specificity in influenza A virus transmission and pathogenesis publication-title: EMBO J. doi: 10.1002/embj.201387442 – volume: 106 start-page: 21312 year: 2009 ident: ref_59 article-title: Adaptive strategies of the influenza virus polymerase for replication in humans publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0911915106 – ident: ref_60 doi: 10.1371/journal.ppat.1001034 – volume: 4 start-page: 151 year: 2013 ident: ref_85 article-title: Genetic variability and evolutionary dynamics of viruses of the family Closteroviridae publication-title: Front. Microbiol. doi: 10.3389/fmicb.2013.00151 – volume: 5 start-page: 1015 year: 2006 ident: ref_68 article-title: Antiviral agents active against influenza A viruses publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd2175 – volume: 20 start-page: 1087 year: 2014 ident: ref_75 article-title: Novel reassortant influenza A(H5N8) viruses, South Korea, 2014 publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2006.140233 – volume: 23 start-page: 2336 year: 2006 ident: ref_40 article-title: Avian influenza virus exhibits rapid evolutionary dynamics publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msl102 – volume: 116 start-page: 210 year: 2017 ident: ref_65 article-title: Human infection caused by an avian influenza A (H7N9) virus with a polybasic cleavage site in Taiwan, 2017 publication-title: J. Formos. Med. Assoc. doi: 10.1016/j.jfma.2017.02.011 – volume: 204 start-page: 592 year: 2011 ident: ref_38 article-title: Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection publication-title: J. Infect. Dis. doi: 10.1093/infdis/jir352 – volume: 90 start-page: 1009 year: 2016 ident: ref_56 article-title: Differential recognition of influenza A viruses by M1(58–66) epitope-specific CD8(+) T Cells is determined by extraepitopic amino acid residues publication-title: J. Virol. doi: 10.1128/JVI.02439-15 – volume: 356 start-page: 1845 year: 2001 ident: ref_87 article-title: The haemagglutinin gene, but not the neuraminidase gene, of 'Spanish flu' was a recombinant publication-title: Philos. Trans. R Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2001.0998 – volume: 105 start-page: 17736 year: 2008 ident: ref_15 article-title: Structure of influenza Hemagglutinin in complex with an inhibitor of membrane fusion publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0807142105 – volume: 380 start-page: 12 year: 2008 ident: ref_84 article-title: Homologous recombination evidence in human and swine influenza A viruses publication-title: Virology doi: 10.1016/j.virol.2008.07.014 – volume: 10 start-page: 121 year: 2017 ident: ref_101 article-title: Drug resistance in influenza A virus: The epidemiology and management publication-title: Infect. Drug Resist. doi: 10.2147/IDR.S105473 – volume: 26 start-page: 391 year: 1981 ident: ref_28 article-title: Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells publication-title: Cell doi: 10.1016/0092-8674(81)90208-7 – volume: 43 start-page: 10321 year: 2015 ident: ref_31 article-title: Robust expression of vault RNAs induced by influenza A virus plays a critical role in suppression of PKR-mediated innate immunity publication-title: Nucleic Acids Res. – volume: 27 start-page: 6363 year: 2009 ident: ref_55 article-title: Influenza virus CTL epitopes, remarkably conserved and remarkably variable publication-title: Vaccine doi: 10.1016/j.vaccine.2009.01.016 – volume: 20 start-page: 542 year: 2014 ident: ref_96 article-title: Active surveillance for avian influenza virus, Egypt, 2010-2012 publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2004.131295 – volume: 103 start-page: 199 year: 2004 ident: ref_21 article-title: Molecular mechanisms of influenza virus resistance to neuraminidase inhibitors publication-title: Virus. Res. doi: 10.1016/j.virusres.2004.02.034 – volume: 90 start-page: 3794 year: 2016 ident: ref_51 article-title: Amino acid substitutions that affect receptor binding and stability of the Hemagglutinin of influenza A/H7N9 virus publication-title: J. Virol. doi: 10.1128/JVI.03052-15 – volume: 93 start-page: 987 year: 2012 ident: ref_54 article-title: Role of Itk signalling in the interaction between influenza A virus and T-cells publication-title: J. Gen. Virol. doi: 10.1099/vir.0.041228-0 – volume: 9 start-page: 1078 year: 2013 ident: ref_16 article-title: New world bats harbor diverse influenza A viruses publication-title: PLoS Path. doi: 10.1371/journal.ppat.1003657 – volume: 56 start-page: 152 year: 1992 ident: ref_45 article-title: Evolution and ecology of influenza A viruses publication-title: Curr. Top Microbiol. Immunol. – volume: 23 start-page: 637 year: 2017 ident: ref_77 article-title: Highly pathogenic avian influenza A(H5N8) virus in wild migratory birds, Qinghai Lake, China publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2304.161866 – volume: 91 start-page: 572 year: 2001 ident: ref_7 article-title: A history of influenza publication-title: J. Appl. Microbiol. doi: 10.1046/j.1365-2672.2001.01492.x – volume: 6 start-page: 23746 year: 2016 ident: ref_104 article-title: Targeted disruption of influenza A virus hemagglutinin in genetically modified mice reduces viral replication and improves disease outcome publication-title: Sci. Rep. doi: 10.1038/srep23746 – volume: 124 start-page: 12 year: 2007 ident: ref_27 article-title: Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes publication-title: Virus. Res. doi: 10.1016/j.virusres.2006.09.013 – volume: 23 start-page: 359 year: 2017 ident: ref_73 article-title: Novel reassortant clade 2.3.4.4 avian influenza A(H5N8) virus in wild aquatic birds, Russia, 2016 publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2302.161252 – volume: 64 start-page: 111 year: 2015 ident: ref_78 article-title: Outbreaks of avian influenza A (H5N2), (H5N8), and (H5N1) among birds—United States, December 2014–January 2015 publication-title: MMWR Morb. Mortal. Wkly. Rep. – volume: 51 start-page: 407 year: 2000 ident: ref_12 article-title: Global epidemiology of influenza: Past and present publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.51.1.407 – volume: 45 start-page: 1 year: 2014 ident: ref_69 article-title: The NS segment of H5N1 avian influenza viruses (AIV) enhances the virulence of an H7N1 AIV in chickens publication-title: Vet. Res. – volume: 95 start-page: 409 year: 1998 ident: ref_19 article-title: Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation publication-title: Cell doi: 10.1016/S0092-8674(00)81771-7 – volume: 84 start-page: 558 year: 2010 ident: ref_66 article-title: The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis publication-title: J. Virol. doi: 10.1128/JVI.01785-09 – volume: 9 start-page: 590 year: 2011 ident: ref_14 article-title: Influenza A viruses: New research developments publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro2613 – volume: 30 start-page: 917 year: 2016 ident: ref_52 article-title: Role of R292K mutation in influenza H7N9 neuraminidase toward oseltamivir susceptibility: MD and MM/PB(GB)SA study publication-title: J. Comput. Aided Mol. Des. doi: 10.1007/s10822-016-9981-5 – ident: ref_8 doi: 10.1186/1471-2334-14-480 – volume: 6 start-page: 33334 year: 2016 ident: ref_53 article-title: Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition publication-title: Sci. Rep. doi: 10.1038/srep33334 – volume: 8 start-page: 1 year: 2007 ident: ref_70 article-title: Up to new tricks—A review of cross-species transmission of influenza A viruses publication-title: Anim. Health Res. Rev. doi: 10.1017/S1466252307001272 – volume: 22 start-page: 975 year: 2016 ident: ref_26 article-title: Functional balance between neuraminidase and haemagglutinin in influenza viruses publication-title: Clin. Microbiol. Infect. doi: 10.1016/j.cmi.2016.07.007 – volume: 8 start-page: 1287 year: 2006 ident: ref_23 article-title: Roles of neuraminidase in the initial stage of influenza virus infection publication-title: Microbes. Infect. doi: 10.1016/j.micinf.2005.12.008 – volume: 193 start-page: 503 year: 1993 ident: ref_42 article-title: Genetic reassortment between avian and human influenza A viruses in Italian pigs publication-title: Virology doi: 10.1006/viro.1993.1155 – volume: 363 start-page: 2036 year: 2010 ident: ref_99 article-title: Influenza vaccines for the future publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1002842 – volume: 361 start-page: 115 year: 2009 ident: ref_72 article-title: Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus publication-title: N. Engl. J. Med. doi: 10.1056/NEJMp0904572 – volume: 182 start-page: 475 year: 1991 ident: ref_13 article-title: Comparison of complete amino acid sequences among 13 serotypes of Hemagglutinins and receptor-binding properties of influenza A viruses indirect immunofluorescence publication-title: Virology doi: 10.1016/0042-6822(91)90588-3 – ident: ref_64 doi: 10.1371/journal.ppat.1005583 – volume: 84 start-page: 2285 year: 2003 ident: ref_67 article-title: the origin of the 1918 pandemic influenza virus: A continuing enigma publication-title: J. Gen. Virol. doi: 10.1099/vir.0.19302-0 – volume: 362 start-page: 1733 year: 2003 ident: ref_17 article-title: Influenza publication-title: Lancet. doi: 10.1016/S0140-6736(03)14854-4 – volume: 87 start-page: 9911 year: 2013 ident: ref_50 article-title: Increased acid stability of the Hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets publication-title: J. Virol. doi: 10.1128/JVI.01175-13 – volume: 6 start-page: 26787 year: 2016 ident: ref_105 article-title: Host genetics determine susceptibility to avian influenza infection and transmission dynamics publication-title: Sci. Rep. doi: 10.1038/srep26787 – volume: 7 start-page: 129 year: 2016 ident: ref_30 article-title: lncRNAs regulate the innate immune response to viral infection publication-title: Wiley Interdiscip. Rev. RNA doi: 10.1002/wrna.1321 – volume: 7 start-page: 2352 year: 2017 ident: ref_63 article-title: The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage publication-title: Sci. Rep. doi: 10.1038/s41598-017-02598-z – volume: 69 start-page: 1099 year: 1995 ident: ref_22 article-title: Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding publication-title: J. Virol. doi: 10.1128/jvi.69.2.1099-1106.1995 – volume: 129 start-page: 21 year: 2016 ident: ref_103 article-title: 4th ISIRV antiviral group conference: Novel antiviral therapies for influenza and other respiratory viruses publication-title: Antiviral. Res. doi: 10.1016/j.antiviral.2016.01.012 – volume: 6 start-page: 712 year: 2015 ident: ref_36 article-title: Induction of innate immunity and its perturbation by influenza viruses publication-title: Protein Cell doi: 10.1007/s13238-015-0191-z – volume: 522 start-page: 102 year: 2015 ident: ref_95 article-title: Dissemination, divergence and establishment of H7N9 influenza viruses in China publication-title: Nature doi: 10.1038/nature14348 – volume: 32 start-page: 513 year: 2014 ident: ref_33 article-title: Interferon-stimulated genes: A complex web of host defenses publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-032713-120231 – volume: 385 start-page: 359 year: 2014 ident: ref_88 article-title: Evolution and ecology of influenza A viruses publication-title: Curr. Top. Microbiol. Immunol. – volume: 383 start-page: 714 year: 2014 ident: ref_62 article-title: Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: A descriptive study publication-title: Lancet. doi: 10.1016/S0140-6736(14)60111-2 – volume: 14 start-page: 315 year: 2014 ident: ref_32 article-title: Innate immunity to influenza virus infection publication-title: Nat. Rev. Immunol. doi: 10.1038/nri3665 – volume: 1323 start-page: 115 year: 2014 ident: ref_102 article-title: Continuing challenges in influenza publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.12462 – volume: 183 start-page: 5180 year: 2009 ident: ref_37 article-title: Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome publication-title: J. Immunol. doi: 10.4049/jimmunol.0804198 – volume: 340 start-page: 1463 year: 2013 ident: ref_41 article-title: An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level publication-title: Science doi: 10.1126/science.1236787 – volume: 368 start-page: 1888 year: 2013 ident: ref_61 article-title: Human infection with a novel avian-origin influenza A (H7N9) virus publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1304459 – volume: 28 start-page: 187 year: 2009 ident: ref_89 article-title: Pandemic influenza—Including a risk assessment of H5N1 publication-title: Rev. Sci. Tech. doi: 10.20506/rst.28.1.1879 – volume: 193 start-page: 1229 year: 2006 ident: ref_2 article-title: Clinical features of influenza C virus infection in children publication-title: J. Infect. Dis. doi: 10.1086/502973 – ident: ref_74 doi: 10.1371/journal.pone.0046183 – volume: 499 start-page: 496 year: 2013 ident: ref_49 article-title: Receptor binding by an H7N9 influenza virus from humans publication-title: Nature doi: 10.1038/nature12372 – ident: ref_34 doi: 10.1371/journal.ppat.1003845 – volume: 63 start-page: 252 year: 2011 ident: ref_4 article-title: A definition for influenza pandemics based on historical records publication-title: J. Infect. doi: 10.1016/j.jinf.2011.04.013 – ident: ref_93 doi: 10.1371/journal.ppat.1006390 – volume: 54 start-page: 196 year: 2000 ident: ref_20 article-title: Influenza virus genetics publication-title: Biomed. Pharmacother. doi: 10.1016/S0753-3322(00)89026-5 – volume: 11 start-page: 3 year: 2010 ident: ref_1 article-title: Perspectives on influenza evolution and the role of research publication-title: Anim. Health Res. Rev. doi: 10.1017/S1466252310000071 – volume: 17 start-page: 822 year: 2017 ident: ref_10 article-title: Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013–17: An epidemiological study of laboratory-confirmed case series publication-title: Lancet. Infect. Dis. doi: 10.1016/S1473-3099(17)30323-7 – volume: 360 start-page: 2605 year: 2009 ident: ref_71 article-title: Emergence of a novel swine-origin influenza A (H1N1) virus in humans publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0903810 – volume: 12 start-page: 1085 year: 2013 ident: ref_98 article-title: The evolving history of influenza viruses and influenza vaccines publication-title: Expert Rev. Vaccines doi: 10.1586/14760584.2013.824709 – volume: 43 start-page: 85 year: 2016 ident: ref_86 article-title: Is a highly pathogenic avian influenza virus H5N1 fragment recombined in PB1 the key for the epidemic of the novel AIV H7N9 in China, 2013? publication-title: Int. J. Infect. Dis. doi: 10.1016/j.ijid.2016.01.002 – volume: 342 start-page: 243 year: 2013 ident: ref_94 article-title: Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses publication-title: Science doi: 10.1126/science.1242917 – volume: 23 start-page: 1368 year: 2017 ident: ref_76 article-title: Genesis of influenza A(H5N8) viruses publication-title: Emerg. Infect. Dis. doi: 10.3201/eid2308.170143 – volume: 86 start-page: 1750 year: 2012 ident: ref_46 article-title: Reassortment and mutation of the avian influenza virus polymerase PA Subunit overcome species barriers publication-title: J. Virol. doi: 10.1128/JVI.06203-11 – volume: 25 start-page: 6852 year: 2007 ident: ref_47 article-title: Influenza vaccine: The challenge of antigenic drift publication-title: Vaccine doi: 10.1016/j.vaccine.2007.07.027 – volume: 4 start-page: 1438 year: 2012 ident: ref_58 article-title: Evasion of influenza A viruses from innate and adaptive immune responses publication-title: Viruses doi: 10.3390/v4091438 – volume: 7 start-page: 43566 year: 2017 ident: ref_9 article-title: Continual antigenic diversification in China leads to global antigenic complexity of avian influenza H5N1 viruses publication-title: Sci. Rep. doi: 10.1038/srep43566 – volume: 17 start-page: 1266 year: 2010 ident: ref_24 article-title: The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.1909 – volume: 54 start-page: 188 year: 2000 ident: ref_5 article-title: The epidemiology and history of influenza publication-title: Biomed. Pharmacother. doi: 10.1016/S0753-3322(00)89025-3 – volume: 7 start-page: 440 year: 2010 ident: ref_44 article-title: Influenza virus evolution, host adaptation, and pandemic formation publication-title: Cell Host Microbe doi: 10.1016/j.chom.2010.05.009 – volume: 204 start-page: 462 year: 1994 ident: ref_81 article-title: Nonhomologous recombination between the hemagglutinin gene and the nucleoprotein gene of an influenza virus publication-title: Virology doi: 10.1006/viro.1994.1555 – volume: 10 start-page: 693 year: 2004 ident: ref_82 article-title: Recombination resulting in virulence shift in avian influenza outbreak, Chile publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1004.030396 – volume: 453 start-page: 615 year: 2008 ident: ref_90 article-title: The genomic and epidemiological dynamics of human influenza A virus publication-title: Nature doi: 10.1038/nature06945 – volume: 296 start-page: 1270 year: 2002 ident: ref_39 article-title: RNA-dependent RNA polymerases, viruses, and RNA silencing publication-title: Science doi: 10.1126/science.1069132 – volume: 52 start-page: 428 year: 2009 ident: ref_25 article-title: Interspecies transmission and host restriction of avian H5N1 influenza virus publication-title: Sci. China C Life Sci. doi: 10.1007/s11427-009-0062-z – volume: 3 start-page: 3058 year: 2013 ident: ref_48 article-title: Adaptation of novel H7N9 influenza A virus to human receptors publication-title: Sci. Rep. doi: 10.1038/srep03058 – volume: 3 start-page: 158 year: 2008 ident: ref_43 article-title: The pig as a mixing vessel for influenza viruses: Human and veterinary implications publication-title: J. Mol. Genet. Med. – volume: 25 start-page: 7656 year: 2007 ident: ref_100 article-title: Safety and immunogenicity of a high dosage trivalent influenza vaccine among elderly subjects publication-title: Vaccine doi: 10.1016/j.vaccine.2007.08.042 – volume: 88 start-page: 8375 year: 2014 ident: ref_35 article-title: Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression publication-title: J. Virol. doi: 10.1128/JVI.00126-14 – volume: 432 start-page: 904 year: 2004 ident: ref_6 article-title: Transmissibility of 1918 pandemic influenza publication-title: Nature doi: 10.1038/nature03063 – volume: 84 start-page: 2691 year: 2003 ident: ref_83 article-title: Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses publication-title: J. Gen. Virol. doi: 10.1099/vir.0.19277-0 – volume: 337 start-page: 199 year: 2012 ident: ref_11 article-title: An overlapping protein-coding region in influenza A virus segment 3 modulates the host response publication-title: Science doi: 10.1126/science.1222213 – volume: 356 start-page: 1861 year: 2001 ident: ref_3 article-title: The evolution of human influenza viruses publication-title: Philos. Trans. R. Soc. Lond. B. Biol. Sci. doi: 10.1098/rstb.2001.0999 – volume: 88 start-page: 530 year: 2007 ident: ref_57 article-title: Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones publication-title: J. Gen. Virol. doi: 10.1099/vir.0.82120-0 – volume: 5 start-page: 2424 year: 2013 ident: ref_29 article-title: Transport of the Influenza virus genome from nucleus to nucleus publication-title: Viruses doi: 10.3390/v5102424 – volume: 381 start-page: 1916 year: 2013 ident: ref_92 article-title: Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: Clinical analysis and characterisation of viral genome publication-title: Lancet. doi: 10.1016/S0140-6736(13)60903-4 – volume: 8 start-page: 741 year: 2017 ident: ref_80 article-title: Characterization of novel reassortant influenza A (H5N2) viruses isolated from poultry in Eastern China, 2015 publication-title: Front. Microbiol. doi: 10.3389/fmicb.2017.00741 – volume: 48 start-page: 33 year: 2017 ident: ref_79 article-title: Infectivity, transmission and pathogenicity of H5 highly pathogenic avian influenza clade 2.3.4.4 (H5N8 and H5N2) United States index viruses in Pekin ducks and Chinese geese publication-title: Vet. Res. doi: 10.1186/s13567-017-0435-4 – reference: 23049973 - PLoS One. 2012;7(9):e46183 – reference: 9814710 - Cell. 1998 Oct 30;95(3):409-17 – reference: 10774473 - Annu Rev Med. 2000;51:407-21 – reference: 24130481 - PLoS Pathog. 2013;9(10):e1003657 – reference: 19618626 - Rev Sci Tech. 2009 Apr;28(1):187-202 – reference: 19995968 - Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6 – reference: 24104053 - Viruses. 2013 Oct 02;5(10):2424-46 – reference: 22302878 - J Gen Virol. 2012 May;93(Pt 5):987-97 – reference: 27033724 - Sci Rep. 2016 Apr 01;6:23746 – reference: 19471865 - Sci China C Life Sci. 2009 May;52(5):428-38 – reference: 26872862 - Antiviral Res. 2016 May;129:21-38 – reference: 15163510 - Virus Res. 2004 Jul;103(1-2):199-203 – reference: 24009358 - Science. 2013 Oct 11;342(6155):243-7 – reference: 23805130 - Front Microbiol. 2013 Jun 26;4:151 – reference: 2024485 - Virology. 1991 Jun;182(2):475-85 – reference: 28609260 - Emerg Infect Dis. 2017 Aug;23 (8):1368-1371 – reference: 19474418 - N Engl J Med. 2009 Jul 9;361(2):115-9 – reference: 17719149 - Vaccine. 2007 Sep 28;25(39-40):6852-62 – reference: 20542248 - Cell Host Microbe. 2010 Jun 25;7(6):440-51 – reference: 19423869 - N Engl J Med. 2009 Jun 18;360(25):2605-15 – reference: 28169827 - Emerg Infect Dis. 2017 Apr;23 (4):637-641 – reference: 25186370 - BMC Infect Dis. 2014 Sep 04;14:480 – reference: 27629812 - Sci Rep. 2016 Sep 15;6:33334 – reference: 17913310 - Vaccine. 2007 Nov 1;25(44):7656-63 – reference: 7326745 - Cell. 1981 Nov;26(3 Pt 1):391-400 – reference: 19786538 - J Immunol. 2009 Oct 15;183(8):5180-9 – reference: 10872718 - Biomed Pharmacother. 2000 May;54(4):196-209 – reference: 23787694 - Nature. 2013 Jul 25;499(7459):496-9 – reference: 10872717 - Biomed Pharmacother. 2000 May;54(4):188-95 – reference: 27875109 - Emerg Infect Dis. 2017 Feb;23 (2):359-360 – reference: 12016304 - Science. 2002 May 17;296(5571):1270-3 – reference: 28617868 - PLoS Pathog. 2017 Jun 15;13(6):e1006390 – reference: 16682242 - Microbes Infect. 2006 Apr;8(5):1287-93 – reference: 22090127 - J Virol. 2012 Feb;86(3):1750-7 – reference: 20700447 - PLoS Pathog. 2010 Aug 05;6(8):e1001034 – reference: 24655395 - Emerg Infect Dis. 2014 Apr;20(4):542-51 – reference: 12917448 - J Gen Virol. 2003 Sep;84(Pt 9):2285-92 – reference: 24391501 - PLoS Pathog. 2014 Jan;10 (1):e1003845 – reference: 11576290 - J Appl Microbiol. 2001 Oct;91(4):572-9 – reference: 15200862 - Emerg Infect Dis. 2004 Apr;10(4):693-9 – reference: 24856098 - Emerg Infect Dis. 2014 Jun;20(6):1087-9 – reference: 24891213 - Ann N Y Acad Sci. 2014 Sep;1323:115-39 – reference: 19565018 - J Mol Genet Med. 2008 Nov 27;3(1):158-66 – reference: 16945980 - Mol Biol Evol. 2006 Dec;23(12):2336-41 – reference: 18721995 - Virology. 2008 Oct 10;380(1):12-20 – reference: 23623390 - Lancet. 2013 Jun 1;381(9881):1916-25 – reference: 24762827 - Nat Rev Immunol. 2014 May;14(5):315-28 – reference: 28458567 - Infect Drug Resist. 2017 Apr 20;10 :121-134 – reference: 28487690 - Front Microbiol. 2017 Apr 25;8:741 – reference: 22745253 - Science. 2012 Jul 13;337(6091):199-204 – reference: 21083388 - N Engl J Med. 2010 Nov 18;363(21):2036-44 – reference: 13679603 - J Gen Virol. 2003 Oct;84(Pt 10):2691-703 – reference: 26778522 - Int J Infect Dis. 2016 Feb;43:85-9 – reference: 26667656 - Wiley Interdiscip Rev RNA. 2016 Jan-Feb;7(1):129-43 – reference: 20591210 - Anim Health Res Rev. 2010 Jun;11(1):3-18 – reference: 23824818 - J Virol. 2013 Sep;87(17):9911-22 – reference: 19820273 - Postgrad Med. 2009 Sep;121(5):43-7 – reference: 25762140 - Nature. 2015 Jun 4;522(7554):102-5 – reference: 18418375 - Nature. 2008 May 29;453(7195):615-9 – reference: 15602562 - Nature. 2004 Dec 16;432(7019):904-6 – reference: 28259506 - J Formos Med Assoc. 2017 Mar;116(3):210-212 – reference: 24507376 - Lancet. 2014 Feb 22;383(9918):714-21 – reference: 26206138 - Protein Cell. 2015 Oct;6(10):712-21 – reference: 23641058 - Science. 2013 Jun 21;340(6139):1463-7 – reference: 28539661 - Sci Rep. 2017 May 24;7(1):2352 – reference: 27714494 - J Comput Aided Mol Des. 2016 Oct;30(10 ):917-926 – reference: 24555472 - Annu Rev Immunol. 2014;32:513-45 – reference: 24024871 - Expert Rev Vaccines. 2013 Sep;12(9):1085-94 – reference: 19840674 - Vaccine. 2009 Oct 23;27(45):6363-5 – reference: 27097026 - PLoS Pathog. 2016 Apr 20;12(4):e1005583 – reference: 17139286 - Nat Rev Drug Discov. 2006 Dec;5(12):1015-25 – reference: 26792744 - J Virol. 2016 Jan 20;90(7):3794-9 – reference: 19828614 - J Virol. 2010 Jan;84(1):558-64 – reference: 11779385 - Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1861-70 – reference: 24460592 - Vet Res. 2014 Jan 25;45:7 – reference: 20852645 - Nat Struct Mol Biol. 2010 Oct;17(10):1266-8 – reference: 1579108 - Microbiol Rev. 1992 Mar;56(1):152-79 – reference: 28592320 - Vet Res. 2017 Jun 7;48(1):33 – reference: 25654614 - MMWR Morb Mortal Wkly Rep. 2015 Feb 6;64(4):111 – reference: 17081640 - Virus Res. 2007 Mar;124(1-2):12-21 – reference: 26537686 - J Virol. 2015 Nov 04;90(2):1009-22 – reference: 7815489 - J Virol. 1995 Feb;69(2):1099-106 – reference: 17251571 - J Gen Virol. 2007 Feb;88(Pt 2):530-5 – reference: 11779383 - Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1845-55 – reference: 8438586 - Virology. 1993 Mar;193(1):503-6 – reference: 27279280 - Sci Rep. 2016 Jun 09;6:26787 – reference: 24990620 - Curr Top Microbiol Immunol. 2014;385:359-75 – reference: 19004788 - Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41 – reference: 17692139 - Anim Health Res Rev. 2007 Jun;8(1):1-21 – reference: 24162312 - Sci Rep. 2013 Oct 28;3:3058 – reference: 21791661 - J Infect Dis. 2011 Aug 15;204(4):592-600 – reference: 26490959 - Nucleic Acids Res. 2015 Dec 2;43(21):10321-37 – reference: 28262734 - Sci Rep. 2017 Mar 06;7:43566 – reference: 24668228 - EMBO J. 2014 Apr 16;33(8):823-41 – reference: 8091680 - Virology. 1994 Oct;204(1):462-5 – reference: 21632115 - J Infect. 2011 Oct;63(4):252-9 – reference: 23577628 - N Engl J Med. 2013 May 16;368(20):1888-97 – reference: 23170167 - Viruses. 2012 Sep;4(9):1438-76 – reference: 24829357 - J Virol. 2014 Aug;88(15):8375-85 – reference: 27424943 - Clin Microbiol Infect. 2016 Dec;22(12 ):975-983 – reference: 14643124 - Lancet. 2003 Nov 22;362(9397):1733-45 – reference: 16586359 - J Infect Dis. 2006 May 1;193(9):1229-35 – reference: 28533172 - Eur J Pharmacol. 2017 Aug 15;809:178-190 – reference: 21747392 - Nat Rev Microbiol. 2011 Jul 11;9(8):590-603 – reference: 28583578 - Lancet Infect Dis. 2017 Aug;17 (8):822-832 |
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