2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

• Published in: International journal of molecular sciences Vol. 21; no. 1; p. 234
• Main Authors: Pajak, B., Siwiak, E., Sołtyka, M., Priebe, A., Zieliński, R., Fokt, I., Ziemniak, M., Jaśkiewicz, A., Borowski, R., Domoradzki, T., Priebe, W.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.12.2019; MDPI
• Subjects: Angiogenesis; Brain cancer; Chemotherapy; Dehydrogenases; Glucose; Hypoxia; Kinases; Metabolism; Phosphorylation; Review; Tumors; anticancer therapy; 2-DG analogs; glioblastoma; 2-deoxy-d-glucose

The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of...