Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development

• Published in: International journal of molecular sciences Vol. 20; no. 18; p. 4438
• Main Authors: Elwakeel, Eiman, Brüggemann, Mirko, Fink, Annika F, Schulz, Marcel H, Schmid, Tobias, Savai, Rajkumar, Brüne, Bernhard, Zarnack, Kathi, Weigert, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.09.2019; MDPI
• Subjects: Adipocytes; Animals; Breast cancer; Cancer; cancer-associated fibroblasts; Carcinoma; Female; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Gene expression; Gene Expression Regulation, Neoplastic; gene signature; Growth factors; Heterogeneity; Homeostasis; mammary carcinoma; Mammary gland; Mammary glands; Mammary Glands, Animal - metabolism; Mammary Glands, Animal - pathology; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - metabolism; Mammary Neoplasms, Animal - pathology; Medical prognosis; Metastases; Mice; Mice, Transgenic; Phenotypic plasticity; Population; Smooth muscle; Transcription, Genetic; transcriptional profiling; Tumorigenesis; Tumors; transcriptional profiling; cancer-associated fibroblasts; cancer; gene signature; mammary carcinoma

Cancer-associated fibroblasts (CAFs) in the tumor microenvironment contribute to all stages of tumorigenesis and are usually considered to be tumor-promoting cells. CAFs show a remarkable degree of heterogeneity, which is attributed to developmental origin or to local environmental niches, resulting...