Unlocking the Memory Component of Alzheimer's Disease: Biological Processes and Pathways across Brain Regions
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly a...
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Published in | Biomolecules (Basel, Switzerland) Vol. 12; no. 2; p. 263 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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06.02.2022
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Abstract | Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly associated with β-amyloid deposits and tau protein misfolding, leading to neurofibrillary tangles. In recent years, however, research has shown that there is a high complexity of mechanisms involved in AD neurophysiology and functional decline enabling its diverse presentation and allowing more questions to arise. In this study, we present a computational approach to facilitate brain region-specific analysis of genes and biological processes involved in the memory process in AD. Utilizing current genetic knowledge we provide a gene set of 265 memory-associated genes in AD, combinations of which can be found co-expressed in 11 different brain regions along with their functional role. The identified genes participate in a spectrum of biological processes ranging from structural and neuronal communication to epigenetic alterations and immune system responses. These findings provide new insights into the molecular background of AD and can be used to bridge the genotype-phenotype gap and allow for new therapeutic hypotheses. |
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AbstractList | Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly associated with β-amyloid deposits and tau protein misfolding, leading to neurofibrillary tangles. In recent years, however, research has shown that there is a high complexity of mechanisms involved in AD neurophysiology and functional decline enabling its diverse presentation and allowing more questions to arise. In this study, we present a computational approach to facilitate brain region-specific analysis of genes and biological processes involved in the memory process in AD. Utilizing current genetic knowledge we provide a gene set of 265 memory-associated genes in AD, combinations of which can be found co-expressed in 11 different brain regions along with their functional role. The identified genes participate in a spectrum of biological processes ranging from structural and neuronal communication to epigenetic alterations and immune system responses. These findings provide new insights into the molecular background of AD and can be used to bridge the genotype–phenotype gap and allow for new therapeutic hypotheses. |
Author | Dovrolis, Nikolas Nikou, Maria Dimitriadis, Nikolaos Gkrouzoudi, Alexandra Maroulakou, Ioanna |
AuthorAffiliation | 1 Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece; ndovroli@med.duth.gr 2 Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece; manikou@affil.duth.gr (M.N.); agkrouzo@affil.duth.gr (A.G.); nikolaosdimitriathis@gmail.com (N.D.) |
AuthorAffiliation_xml | – name: 1 Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece; ndovroli@med.duth.gr – name: 2 Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece; manikou@affil.duth.gr (M.N.); agkrouzo@affil.duth.gr (A.G.); nikolaosdimitriathis@gmail.com (N.D.) |
Author_xml | – sequence: 1 givenname: Nikolas orcidid: 0000-0003-3832-9939 surname: Dovrolis fullname: Dovrolis, Nikolas organization: Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece – sequence: 2 givenname: Maria surname: Nikou fullname: Nikou, Maria organization: Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece – sequence: 3 givenname: Alexandra orcidid: 0000-0001-5327-3924 surname: Gkrouzoudi fullname: Gkrouzoudi, Alexandra organization: Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece – sequence: 4 givenname: Nikolaos surname: Dimitriadis fullname: Dimitriadis, Nikolaos organization: Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece – sequence: 5 givenname: Ioanna surname: Maroulakou fullname: Maroulakou, Ioanna organization: Laboratory of Genetics & Genomics of Cancer and Chronic Diseases, Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35204764$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.2139/ssrn.3206268 10.1371/journal.pone.0069807 10.1016/j.neuropsychologia.2017.11.033 10.1186/s13195-017-0320-4 10.1016/j.cell.2007.04.035 10.1093/nar/gku631 10.1109/TNSRE.2020.3014951 10.1101/gr.1863004 10.1038/s41419-018-1295-1 10.1038/nprot.2015.052 10.1109/TNSRE.2021.3101240 10.1038/75556 10.1152/jn.00338.2011 10.1080/15548627.2020.1760623 10.18632/aging.102840 10.3390/ijms23010090 10.3389/fcell.2018.00008 10.1016/j.ijpsycho.2008.05.328 10.3389/fnagi.2018.00437 10.1155/2011/738137 10.1016/j.bbadis.2009.05.001 10.1007/s00429-019-01945-2 10.1016/j.pnpbp.2017.11.016 10.1002/hipo.20240 10.1016/S0911-6044(00)00008-7 10.1016/j.neurobiolaging.2018.09.003 10.3389/fnins.2018.00916 10.1093/nar/gkab254 10.1034/j.1600-0404.107.s179.5.x 10.1016/S1074-7427(03)00008-X 10.3389/fpsyt.2020.00142 10.55782/ane-2004-1495 10.1007/s12264-021-00796-4 10.1007/s12035-019-1500-y 10.1111/ejn.13936 10.1093/nar/gkw1133 10.1186/gb-2013-14-7-r78 10.1002/cpbi.12 10.1038/nrn2881 10.4161/auto.7.5.14811 10.2165/11590190-000000000-00000 10.1002/bab.2112 10.1016/j.bbr.2010.11.039 10.1016/j.isci.2020.101769 10.1038/mp.2017.147 10.1016/j.drudis.2017.03.009 10.1016/j.physbeh.2020.112988 10.1093/nar/gkw937 10.1016/j.ymthe.2019.11.017 10.1038/s41592-020-01033-y 10.1038/nn.4637 10.1007/s10072-010-0454-7 10.1038/s41467-019-11409-0 10.1073/pnas.1107411108 10.3390/ijms222212280 10.1007/s12035-014-8637-5 10.1097/01.CHI.0000046835.90931.32 10.1038/nature07456 10.1002/hbm.22531 10.3389/fcell.2021.653101 10.1212/01.wnl.0000437306.37850.22 10.1080/15548627.2017.1379633 10.1093/nar/gkaa1027 10.1101/cshperspect.a021287 10.3390/genes10100798 10.1016/j.neuron.2021.06.024 10.1093/nar/gkn851 10.1159/000076353 10.1038/s41586-019-1195-2 10.1006/nlme.2002.4082 10.3390/jpm11121275 10.1159/000515661 10.1038/cr.2009.56 10.3389/fphar.2018.00047 10.1038/s41598-020-72024-4 10.1016/j.biopsych.2019.05.008 10.1016/j.cortex.2019.09.009 10.1155/2021/5514839 10.1101/719930 |
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Keywords | co-expression Alzheimer’s Disease memory functional analysis computational |
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References | Winner (ref_69) 2015; 7 Yeo (ref_15) 2011; 106 McGaugh (ref_10) 2002; 78 Xia (ref_35) 2015; 10 Wheway (ref_75) 2018; 6 Nilsson (ref_3) 2003; 107 ref_12 Li (ref_26) 2021; 29 ref_56 ref_55 Frigerio (ref_60) 2013; 81 Burdakov (ref_13) 2020; 223 Sozinova (ref_8) 2008; 3 ref_51 Lai (ref_71) 2009; 1792 Aguilar (ref_74) 2017; 9 Cai (ref_64) 2021; 17 Hart (ref_61) 2019; 10 Gerstner (ref_86) 2010; 11 Min (ref_28) 2014; 35 Ma (ref_77) 2009; 19 Hartley (ref_6) 2007; 17 Kerfoot (ref_19) 2018; 9 Duncan (ref_78) 2021; 9 (ref_82) 2008; 455 Coley (ref_83) 2018; 82 Ashburner (ref_40) 2000; 25 Duma (ref_17) 2019; 121 ref_25 Xiao (ref_42) 2009; 37 ref_68 Duan (ref_27) 2020; 28 Yang (ref_65) 2017; 13 Hieronymus (ref_84) 2018; 23 ref_62 Cipriani (ref_1) 2011; 32 Guarino (ref_16) 2019; 10 Long (ref_29) 2018; 12 Karunakaran (ref_72) 2020; 10 Amita (ref_21) 2019; 49 Jegga (ref_67) 2011; 7 Lu (ref_59) 2019; 25 Dovrolis (ref_2) 2017; 22 Jiang (ref_48) 2020; 23 Bravo (ref_30) 2016; 45 Lin (ref_14) 2020; 11 Cirrito (ref_81) 2011; 108 ref_34 Huang (ref_43) 2020; 48 Guo (ref_20) 2018; 108 MacArthur (ref_33) 2017; 45 Girardeau (ref_85) 2017; 20 Hut (ref_87) 2011; 221 Ge (ref_58) 2020; 28 Pugacheva (ref_76) 2007; 129 ref_37 McNamara (ref_52) 2021; 109 Silveri (ref_23) 2000; 13 Chiu (ref_7) 2004; 17 Leidinger (ref_54) 2013; 14 Liu (ref_57) 2021; 28 Rolls (ref_18) 2019; 224 Ochoa (ref_32) 2021; 49 Piras (ref_46) 2020; 12 Gillespie (ref_39) 2005; 33 Ru (ref_41) 2014; 42 ref_47 Vachon (ref_63) 2011; 2011 ref_44 ref_88 Curtis (ref_66) 2020; 87 Mathys (ref_45) 2019; 570 Marx (ref_50) 2021; 18 Geldenhuys (ref_80) 2011; 25 Szklarczyk (ref_38) 2017; 45 Zhu (ref_89) 2019; 10 Wietzikoski (ref_22) 2003; 79 Swarbrick (ref_53) 2019; 56 Boros (ref_70) 2019; 73 Amini (ref_24) 2021; 2021 ref_49 Bolognin (ref_73) 2014; 50 Kihara (ref_79) 2004; 64 ref_9 Stalker (ref_31) 2004; 14 Ressler (ref_11) 2003; 42 Arif (ref_36) 2021; 49 ref_5 ref_4 |
References_xml | – ident: ref_12 doi: 10.2139/ssrn.3206268 – ident: ref_55 doi: 10.1371/journal.pone.0069807 – ident: ref_9 – volume: 108 start-page: 117 year: 2018 ident: ref_20 article-title: A supramodal role of the basal ganglia in memory and motor inhibition: Meta-analytic evidence publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2017.11.033 contributor: fullname: Guo – ident: ref_5 – volume: 9 start-page: 74 year: 2017 ident: ref_74 article-title: Rho GTPases as therapeutic targets in Alzheimer’s disease publication-title: Alzheimers Res. Ther. doi: 10.1186/s13195-017-0320-4 contributor: fullname: Aguilar – volume: 129 start-page: 1351 year: 2007 ident: ref_76 article-title: HEF1-dependent Aurora A activation induces disassembly of the primary cilium publication-title: Cell doi: 10.1016/j.cell.2007.04.035 contributor: fullname: Pugacheva – volume: 42 start-page: e133 year: 2014 ident: ref_41 article-title: The multiMiR R package and database: Integration of microRNA–target interactions along with their disease and drug associations publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku631 contributor: fullname: Ru – volume: 28 start-page: 2164 year: 2020 ident: ref_27 article-title: Topological network analysis of early Alzheimer’s disease based on resting-state EEG publication-title: IEEE Trans. Neural Syst. Rehabil. Eng. doi: 10.1109/TNSRE.2020.3014951 contributor: fullname: Duan – volume: 14 start-page: 951 year: 2004 ident: ref_31 article-title: The Ensembl Web site: Mechanics of a genome browser publication-title: Genome Res. doi: 10.1101/gr.1863004 contributor: fullname: Stalker – volume: 10 start-page: 46 year: 2019 ident: ref_61 article-title: miR-34a: A new player in the regulation of T cell function by modulation of NF-κB signaling publication-title: Cell Death Dis. doi: 10.1038/s41419-018-1295-1 contributor: fullname: Hart – volume: 10 start-page: 823 year: 2015 ident: ref_35 article-title: NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data publication-title: Nat. Protoc. doi: 10.1038/nprot.2015.052 contributor: fullname: Xia – volume: 29 start-page: 1557 year: 2021 ident: ref_26 article-title: Feature extraction and identification of Alzheimer’s disease based on latent factor of multi-channel EEG publication-title: IEEE Trans. Neural Syst. Rehabil. Eng. doi: 10.1109/TNSRE.2021.3101240 contributor: fullname: Li – volume: 25 start-page: 25 year: 2000 ident: ref_40 article-title: Gene Ontology: Tool for the unification of biology publication-title: Nat. Genet. doi: 10.1038/75556 contributor: fullname: Ashburner – volume: 106 start-page: 1125 year: 2011 ident: ref_15 article-title: The organization of the human cerebral cortex estimated by intrinsic functional connectivity publication-title: J. Neurophysiol. doi: 10.1152/jn.00338.2011 contributor: fullname: Yeo – volume: 17 start-page: 1112 year: 2021 ident: ref_64 article-title: NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation publication-title: Autophagy doi: 10.1080/15548627.2020.1760623 contributor: fullname: Cai – volume: 12 start-page: 4124 year: 2020 ident: ref_46 article-title: ESHRD: Deconvolution of brain homogenate RNA expression data to identify cell-type-specific alterations in Alzheimer’s disease publication-title: Aging doi: 10.18632/aging.102840 contributor: fullname: Piras – ident: ref_62 doi: 10.3390/ijms23010090 – volume: 6 start-page: 8 year: 2018 ident: ref_75 article-title: Signaling through the primary cilium publication-title: Front. Cell Dev. Biol. doi: 10.3389/fcell.2018.00008 contributor: fullname: Wheway – volume: 3 start-page: 312 year: 2008 ident: ref_8 article-title: The role of hippocampal parts in verbal memory and activation processes publication-title: Int. J. Psychophysiol. doi: 10.1016/j.ijpsycho.2008.05.328 contributor: fullname: Sozinova – volume: 10 start-page: 437 year: 2019 ident: ref_16 article-title: Executive functions in Alzheimer disease: A systematic review publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2018.00437 contributor: fullname: Guarino – volume: 2011 start-page: 738137 year: 2011 ident: ref_63 article-title: Integrin signaling, cell survival, and anoikis: Distinctions, differences, and differentiation publication-title: J. Signal Transduct. doi: 10.1155/2011/738137 contributor: fullname: Vachon – ident: ref_4 – volume: 1792 start-page: 741 year: 2009 ident: ref_71 article-title: Recent advances in understanding the roles of Cdk5 in synaptic plasticity publication-title: Biochim. Biophys. Acta (BBA) Mol. Basis Dis. doi: 10.1016/j.bbadis.2009.05.001 contributor: fullname: Lai – volume: 224 start-page: 3001 year: 2019 ident: ref_18 article-title: The cingulate cortex and limbic systems for emotion, action, and memory publication-title: Brain Struct. Funct. doi: 10.1007/s00429-019-01945-2 contributor: fullname: Rolls – volume: 33 start-page: D428 year: 2005 ident: ref_39 article-title: Reactome: A knowledgebase of biological pathways publication-title: Nucleic Acids Res. contributor: fullname: Gillespie – volume: 82 start-page: 187 year: 2018 ident: ref_83 article-title: PSD95: A synaptic protein implicated in schizophrenia or autism? publication-title: Prog. Neuro Psychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2017.11.016 contributor: fullname: Coley – volume: 17 start-page: 34 year: 2007 ident: ref_6 article-title: The hippocampus is required for short-term topographical memory in humans publication-title: Hippocampus doi: 10.1002/hipo.20240 contributor: fullname: Hartley – volume: 13 start-page: 129 year: 2000 ident: ref_23 article-title: Language, memory, and the cerebellum publication-title: J. Neurolinguistics doi: 10.1016/S0911-6044(00)00008-7 contributor: fullname: Silveri – volume: 73 start-page: 92 year: 2019 ident: ref_70 article-title: Dendritic spine remodeling accompanies Alzheimer’s disease pathology and genetic susceptibility in cognitively normal aging publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2018.09.003 contributor: fullname: Boros – volume: 12 start-page: 916 year: 2018 ident: ref_29 article-title: A comparative atlas-based recognition of mild cognitive impairment with voxel-based morphometry publication-title: Front. Neurosci. doi: 10.3389/fnins.2018.00916 contributor: fullname: Long – volume: 49 start-page: W271 year: 2021 ident: ref_36 article-title: iNetModels 2.0: An interactive visualization and database of multi-omics data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkab254 contributor: fullname: Arif – volume: 107 start-page: 7 year: 2003 ident: ref_3 article-title: Memory function in normal aging publication-title: Acta Neurol. Scand. doi: 10.1034/j.1600-0404.107.s179.5.x contributor: fullname: Nilsson – volume: 79 start-page: 236 year: 2003 ident: ref_22 article-title: Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system publication-title: Neurobiol. Learn. Mem. doi: 10.1016/S1074-7427(03)00008-X contributor: fullname: Wietzikoski – volume: 11 start-page: 142 year: 2020 ident: ref_14 article-title: Working memory predicts hypothalamus-pituitary-adrenal axis response to psychosocial stress in males publication-title: Front. Psychiatry doi: 10.3389/fpsyt.2020.00142 contributor: fullname: Lin – volume: 64 start-page: 99 year: 2004 ident: ref_79 article-title: Alzheimer’s disease and acetylcholine receptors publication-title: Acta Neurobiol. Exp. doi: 10.55782/ane-2004-1495 contributor: fullname: Kihara – volume: 48 start-page: D148 year: 2020 ident: ref_43 article-title: miRTarBase 2020: Updates to the experimentally validated microRNA–target interaction database publication-title: Nucleic Acids Res. contributor: fullname: Huang – ident: ref_47 doi: 10.1007/s12264-021-00796-4 – volume: 56 start-page: 6156 year: 2019 ident: ref_53 article-title: Systematic review of miRNA as biomarkers in Alzheimer’s disease publication-title: Mol. Neurobiol. doi: 10.1007/s12035-019-1500-y contributor: fullname: Swarbrick – volume: 49 start-page: 712 year: 2019 ident: ref_21 article-title: Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia publication-title: Eur. J. Neurosci. doi: 10.1111/ejn.13936 contributor: fullname: Amita – volume: 45 start-page: D896 year: 2017 ident: ref_33 article-title: The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw1133 contributor: fullname: MacArthur – volume: 14 start-page: 1 year: 2013 ident: ref_54 article-title: A blood based 12-miRNA signature of Alzheimer disease patients publication-title: Genome Biol. doi: 10.1186/gb-2013-14-7-r78 contributor: fullname: Leidinger – ident: ref_44 doi: 10.1002/cpbi.12 – volume: 11 start-page: 577 year: 2010 ident: ref_86 article-title: Circadian rhythms and memory formation publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2881 contributor: fullname: Gerstner – ident: ref_34 – volume: 7 start-page: 477 year: 2011 ident: ref_67 article-title: Systems biology of the autophagy-lysosomal pathway publication-title: Autophagy doi: 10.4161/auto.7.5.14811 contributor: fullname: Jegga – volume: 25 start-page: 765 year: 2011 ident: ref_80 article-title: Role of serotonin in Alzheimer’s disease publication-title: CNS Drugs doi: 10.2165/11590190-000000000-00000 contributor: fullname: Geldenhuys – ident: ref_68 doi: 10.1002/bab.2112 – volume: 221 start-page: 466 year: 2011 ident: ref_87 article-title: The cholinergic system, circadian rhythmicity, and time memory publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2010.11.039 contributor: fullname: Hut – volume: 23 start-page: 101769 year: 2020 ident: ref_48 article-title: scREAD: A single-cell RNA-Seq database for Alzheimer’s Disease publication-title: iScience doi: 10.1016/j.isci.2020.101769 contributor: fullname: Jiang – volume: 23 start-page: 1731 year: 2018 ident: ref_84 article-title: Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: A mega-analysis of citalopram and paroxetine in adult depression publication-title: Mol. Psychiatry doi: 10.1038/mp.2017.147 contributor: fullname: Hieronymus – volume: 22 start-page: 805 year: 2017 ident: ref_2 article-title: Laying in silico pipelines for drug repositioning: A paradigm in ensemble analysis for neurodegenerative diseases publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2017.03.009 contributor: fullname: Dovrolis – volume: 223 start-page: 112988 year: 2020 ident: ref_13 article-title: The hypothalamus as a primary coordinator of memory updating publication-title: Physiol. Behav. doi: 10.1016/j.physbeh.2020.112988 contributor: fullname: Burdakov – volume: 45 start-page: D362 year: 2017 ident: ref_38 article-title: The STRING database in 2017: Quality-controlled protein–protein association networks, made broadly accessible publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw937 contributor: fullname: Szklarczyk – volume: 28 start-page: 503 year: 2020 ident: ref_58 article-title: Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2019.11.017 contributor: fullname: Ge – ident: ref_37 – volume: 18 start-page: 9 year: 2021 ident: ref_50 article-title: Method of the Year: Spatially resolved transcriptomics publication-title: Nat. Methods doi: 10.1038/s41592-020-01033-y contributor: fullname: Marx – volume: 20 start-page: 1634 year: 2017 ident: ref_85 article-title: Reactivations of emotional memory in the hippocampus–amygdala system during sleep publication-title: Nat. Neurosci. doi: 10.1038/nn.4637 contributor: fullname: Girardeau – volume: 32 start-page: 275 year: 2011 ident: ref_1 article-title: Alzheimer and his disease: A brief history publication-title: Neurol. Sci. doi: 10.1007/s10072-010-0454-7 contributor: fullname: Cipriani – volume: 10 start-page: 3469 year: 2019 ident: ref_89 article-title: Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription publication-title: Nat. Commun. doi: 10.1038/s41467-019-11409-0 contributor: fullname: Zhu – volume: 45 start-page: D833 year: 2016 ident: ref_30 article-title: DisGeNET: A comprehensive platform integrating information on human disease-associated genes and variants publication-title: Nucleic Acids Res. contributor: fullname: Bravo – volume: 108 start-page: 14968 year: 2011 ident: ref_81 article-title: Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1107411108 contributor: fullname: Cirrito – ident: ref_88 doi: 10.3390/ijms222212280 – volume: 50 start-page: 406 year: 2014 ident: ref_73 article-title: The potential role of rho GTPases in Alzheimer’s disease pathogenesis publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8637-5 contributor: fullname: Bolognin – volume: 25 start-page: 8499 year: 2019 ident: ref_59 article-title: MicroRNA-27a-3p downregulation inhibits inflammatory response and hippocampal neuronal cell apoptosis by upregulating mitogen-activated protein kinase 4 (MAP2K4) expression in epilepsy: In vivo and in vitro studies publication-title: Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. contributor: fullname: Lu – volume: 42 start-page: 612 year: 2003 ident: ref_11 article-title: Genetics of childhood disorders: L. Learning and memory, part 3: Fear conditioning publication-title: J. Am. Acad. Child Adolesc. Psychiatry doi: 10.1097/01.CHI.0000046835.90931.32 contributor: fullname: Ressler – ident: ref_25 – volume: 455 start-page: 903 year: 2008 ident: ref_82 article-title: Neuroligins and neurexins link synaptic function to cognitive disease publication-title: Nature doi: 10.1038/nature07456 – volume: 35 start-page: 5052 year: 2014 ident: ref_28 article-title: Multi-atlas based representations for Alzheimer’s disease diagnosis publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.22531 contributor: fullname: Min – volume: 9 start-page: 460 year: 2021 ident: ref_78 article-title: Neuron-oligodendrocyte interactions in the structure and integrity of axons publication-title: Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.653101 contributor: fullname: Duncan – volume: 81 start-page: 2103 year: 2013 ident: ref_60 article-title: Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease publication-title: Neurology doi: 10.1212/01.wnl.0000437306.37850.22 contributor: fullname: Frigerio – volume: 13 start-page: 2028 year: 2017 ident: ref_65 article-title: NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models publication-title: Autophagy doi: 10.1080/15548627.2017.1379633 contributor: fullname: Yang – volume: 49 start-page: D1302 year: 2021 ident: ref_32 article-title: Open Targets Platform: Supporting systematic drug–target identification and prioritisation publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa1027 contributor: fullname: Ochoa – volume: 7 start-page: a021287 year: 2015 ident: ref_69 article-title: Adult neurogenesis in neurodegenerative diseases publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a021287 contributor: fullname: Winner – ident: ref_49 doi: 10.3390/genes10100798 – volume: 109 start-page: 2204 year: 2021 ident: ref_52 article-title: Replenishing our mind orchards: Enhancing myelin renewal to rescue cognition in Alzheimer’s disease publication-title: Neuron doi: 10.1016/j.neuron.2021.06.024 contributor: fullname: McNamara – volume: 37 start-page: D105 year: 2009 ident: ref_42 article-title: miRecords: An integrated resource for microRNA–target interactions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn851 contributor: fullname: Xiao – volume: 17 start-page: 174 year: 2004 ident: ref_7 article-title: Getting lost: Directed attention and executive functions in early Alzheimer’s disease patients publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000076353 contributor: fullname: Chiu – volume: 570 start-page: 332 year: 2019 ident: ref_45 article-title: Single-cell transcriptomic analysis of Alzheimer’s disease publication-title: Nature doi: 10.1038/s41586-019-1195-2 contributor: fullname: Mathys – volume: 78 start-page: 539 year: 2002 ident: ref_10 article-title: Amygdala modulation of memory consolidation: Interaction with other brain systems publication-title: Neurobiol. Learn. Mem. doi: 10.1006/nlme.2002.4082 contributor: fullname: McGaugh – ident: ref_56 doi: 10.3390/jpm11121275 – volume: 28 start-page: 1 year: 2021 ident: ref_57 article-title: miR-124-3p Ameliorates Isoflurane-Induced Learning and Memory Impairment via Targeting STAT3 and Inhibiting Neuroinflammation publication-title: Neuroimmunomodulation doi: 10.1159/000515661 contributor: fullname: Liu – volume: 19 start-page: 672 year: 2009 ident: ref_77 article-title: Adult neural stem cells in the mammalian central nervous system publication-title: Cell Res. doi: 10.1038/cr.2009.56 contributor: fullname: Ma – volume: 9 start-page: 47 year: 2018 ident: ref_19 article-title: Contributions of the nucleus accumbens shell in mediating the enhancement in memory following noradrenergic activation of either the amygdala or hippocampus publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.00047 contributor: fullname: Kerfoot – volume: 10 start-page: 15629 year: 2020 ident: ref_72 article-title: Cilia interactome with predicted protein–protein interactions reveals connections to Alzheimer’s disease, aging and other neuropsychiatric processes publication-title: Sci. Rep. doi: 10.1038/s41598-020-72024-4 contributor: fullname: Karunakaran – volume: 87 start-page: 797 year: 2020 ident: ref_66 article-title: Autophagy dysfunction in Alzheimer’s disease: Mechanistic insights and new therapeutic opportunities publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2019.05.008 contributor: fullname: Curtis – volume: 121 start-page: 277 year: 2019 ident: ref_17 article-title: Functional dissociation of anterior cingulate cortex and intraparietal sulcus in visual working memory publication-title: Cortex doi: 10.1016/j.cortex.2019.09.009 contributor: fullname: Duma – volume: 2021 start-page: 5514839 year: 2021 ident: ref_24 article-title: Diagnosis of Alzheimer’s Disease Severity with fMRI Images Using Robust Multitask Feature Extraction Method and Convolutional Neural Network (CNN) publication-title: Comput. Math. Methods Med. doi: 10.1155/2021/5514839 contributor: fullname: Amini – ident: ref_51 doi: 10.1101/719930 |
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Snippet | Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD... Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD... |
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SubjectTerms | Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Biological Phenomena Brain Brain - metabolism co-expression Cognitive ability Cognitive Dysfunction - metabolism computational Computational neuroscience Dementia disorders Epigenetics functional analysis Genes Genomes Genotypes Humans Hypothalamus Immune system Memory Neurodegenerative diseases Neurofibrillary tangles Parkinson's disease Phenotypes Protein folding Proteins Tau protein tau Proteins - metabolism β-Amyloid |
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Title | Unlocking the Memory Component of Alzheimer's Disease: Biological Processes and Pathways across Brain Regions |
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