The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

• Published in: The Journal of experimental medicine Vol. 214; no. 9; pp. 2491 - 2506
• Main Authors: Cildir, Gökhan, Pant, Harshita, Lopez, Angel F, Tergaonkar, Vinay
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.09.2017; The Rockefeller University Press
• Subjects: Animal models; Animals; Bacteria; Cell activation; Cell survival; Cues; Cytokines; Drugs; Gene Expression Regulation - physiology; Gene regulation; Histamine; Hormones; Humans; Hypersensitivity; Immune system; Immunoglobulin E; Immunosuppressive agents; Inflammatory diseases; Light effects; Mast cells; Mast Cells - immunology; Mast Cells - physiology; Mice; Peptides; Receptors; Reviews; Tissues; Transcription; Transcriptome - physiology; Viruses

Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tiss...