The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tiss...

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Published inThe Journal of experimental medicine Vol. 214; no. 9; pp. 2491 - 2506
Main Authors Cildir, Gökhan, Pant, Harshita, Lopez, Angel F, Tergaonkar, Vinay
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 04.09.2017
The Rockefeller University Press
Subjects
Animal models
Animals
Bacteria
Cell activation
Cell survival
Cues
Cytokines
Drugs
Gene Expression Regulation - physiology
Gene regulation
Histamine
Hormones
Humans
Hypersensitivity
Immune system
Immunoglobulin E
Immunosuppressive agents
Inflammatory diseases
Light effects
Mast cells
Mast Cells - immunology
Mast Cells - physiology
Mice
Peptides
Receptors
Reviews
Tissues
Transcription
Transcriptome - physiology
Viruses
Online AccessGet full text

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Abstract Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.
AbstractList Cildir et al. discuss the recent findings in transcriptional regulation of mast cell development and activation and provide insights into the plasticity and clinical targeting of mast cell functions. Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.
Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.
Cildir et al. discuss the recent findings in transcriptional regulation of mast cell development and activation and provide insights into the plasticity and clinical targeting of mast cell functions.Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.
Author Tergaonkar, Vinay
Lopez, Angel F
Pant, Harshita
Cildir, Gökhan
AuthorAffiliation 3 Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore
4 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
2 School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
1 Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia
AuthorAffiliation_xml – name: 3 Laboratory of NF-κB Signalling, Institute of Molecular and Cell Biology (IMCB), Singapore, Singapore
– name: 2 School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
– name: 1 Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia
– name: 4 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
Author_xml – sequence: 1
  givenname: Gökhan
  surname: Cildir
  fullname: Cildir, Gökhan
  organization: Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia
– sequence: 2
  givenname: Harshita
  surname: Pant
  fullname: Pant, Harshita
  organization: School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
– sequence: 3
  givenname: Angel F
  surname: Lopez
  fullname: Lopez, Angel F
  organization: Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia
– sequence: 4
  givenname: Vinay
  orcidid: 0000-0001-9009-0844
  surname: Tergaonkar
  fullname: Tergaonkar, Vinay
  email: vinayt@imcb.a-star.edu.sg
  organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28811324$$D View this record in MEDLINE/PubMed
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Snippet Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including...
Cildir et al. discuss the recent findings in transcriptional regulation of mast cell development and activation and provide insights into the plasticity and...
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SubjectTerms Animal models
Animals
Bacteria
Cell activation
Cell survival
Cues
Cytokines
Drugs
Gene Expression Regulation - physiology
Gene regulation
Histamine
Hormones
Humans
Hypersensitivity
Immune system
Immunoglobulin E
Immunosuppressive agents
Inflammatory diseases
Light effects
Mast cells
Mast Cells - immunology
Mast Cells - physiology
Mice
Peptides
Receptors
Reviews
Tissues
Transcription
Transcriptome - physiology
Viruses
Title The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
URI https://www.ncbi.nlm.nih.gov/pubmed/28811324
https://www.proquest.com/docview/1983432444
https://search.proquest.com/docview/1929899934
https://pubmed.ncbi.nlm.nih.gov/PMC5584128
Volume 214
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