Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome

• Published in: International journal of molecular sciences Vol. 20; no. 7; p. 1720
• Main Authors: Chang, Hui Hua, Hsueh, Yuan-Shuo, Cheng, Yung Wen, Ou, Huang-Tz, Wu, Meng-Hsing
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.04.2019; MDPI
• Subjects: Adult; Alleles; Androgens; Antidiabetics; Blood pressure; Diabetes; Female; Gene polymorphism; Genotype; Genotype & phenotype; Glucose Tolerance Test; Humans; Hypoglycemic Agents - therapeutic use; Insulin Resistance; Menstruation; Metabolic response; Metabolism; Metformin; Metformin - therapeutic use; Nucleotides; Oct-2 protein; OCT1; Organic Cation Transporter 1 - genetics; Organic Cation Transporter 1 - metabolism; Organic Cation Transporter 2 - genetics; Ovulation; Patients; Polycystic ovary syndrome; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - genetics; Polymorphism; Polymorphism, Single Nucleotide - genetics; polymorphisms; Prospective Studies; Single-nucleotide polymorphism; metformin; OCT1; polymorphisms; polycystic ovary syndrome

Insulin-sensitizer treatment with metformin is widely used in polycystic ovary syndrome (PCOS). However, the treatment effectiveness shows individual differences in PCOS patients. Organic cation transporter (OCT) 1 and 2 have been reported to mediate metformin transport in the liver and kidney, resp...