Effects of tetrabromobisphenol A, brominated flame retardant, in ICR mice after prenatal and postnatal exposure
Tetrabromobisphenol A (TBBPA), brominated flame retardant, is produced in the largest amounts globally for use in plastics or building materials. TBBPA has been detected in sediment, air at the dismantling plant or human serum samples. In the present study, we examined the effects of prenatal and po...
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Published in | Food and chemical toxicology Vol. 44; no. 8; pp. 1408 - 1413 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Oxford
Elsevier Ltd
01.08.2006
New York, NY Elsevier Science |
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Abstract | Tetrabromobisphenol A (TBBPA), brominated flame retardant, is produced in the largest amounts globally for use in plastics or building materials. TBBPA has been detected in sediment, air at the dismantling plant or human serum samples. In the present study, we examined the effects of prenatal and postnatal exposure to TBBPA in mice. TBBPA (99.1% pure) in diet was administered to pregnant ICR mice at doses of 0% (control), 0.01%, 0.1% or 1.0% from gestational day 0 to weaning at postnatal day 27. The average daily food intake and body weight of dams showed no significant differences between the control and treated groups. There were no dose-related effects on reproductive data. Serum concentrations of total-cholesterol and liver weights of treated dams and offspring were higher than those of the control mice. Histological findings in treated dams or offspring showed the increase of focal necrosis of hepatocytes and inflammatory cell infiltration in the liver, and increase of dilation or atrophy of renal tubules and cyst in the kidney. TBBPA was developed as a new, safe class of flame retardant and was not highly toxic. However, the present data suggested that TBBPA caused a lipid metabolic disorder and hepatic or kidney lesion, under these conditions. |
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AbstractList | Tetrabromobisphenol A (TBBPA), brominated flame retardant, is produced in the largest amounts globally for use in plastics or building materials. TBBPA has been detected in sediment, air at the dismantling plant or human serum samples. In the present study, we examined the effects of prenatal and postnatal exposure to TBBPA in mice. TBBPA (99.1% pure) in diet was administered to pregnant ICR mice at doses of 0% (control), 0.01%, 0.1% or 1.0% from gestational day 0 to weaning at postnatal day 27. The average daily food intake and body weight of dams showed no significant differences between the control and treated groups. There were no dose-related effects on reproductive data. Serum concentrations of total-cholesterol and liver weights of treated dams and offspring were higher than those of the control mice. Histological findings in treated dams or offspring showed the increase of focal necrosis of hepatocytes and inflammatory cell infiltration in the liver, and increase of dilation or atrophy of renal tubules and cyst in the kidney. TBBPA was developed as a new, safe class of flame retardant and was not highly toxic. However, the present data suggested that TBBPA caused a lipid metabolic disorder and hepatic or kidney lesion, under these conditions. |
Author | Yuzawa, K. Nagasawa, A. Kamimura, H. Ogata, A. Yano, N. Takahashi, H. Tada, Y. Kubo, Y. Fujitani, T. Ando, H. |
Author_xml | – sequence: 1 givenname: Y. surname: Tada fullname: Tada, Y. email: Yukie_Tada@member.metro.tokyo.jp – sequence: 2 givenname: T. surname: Fujitani fullname: Fujitani, T. – sequence: 3 givenname: N. surname: Yano fullname: Yano, N. – sequence: 4 givenname: H. surname: Takahashi fullname: Takahashi, H. – sequence: 5 givenname: K. surname: Yuzawa fullname: Yuzawa, K. – sequence: 6 givenname: H. surname: Ando fullname: Ando, H. – sequence: 7 givenname: Y. surname: Kubo fullname: Kubo, Y. – sequence: 8 givenname: A. surname: Nagasawa fullname: Nagasawa, A. – sequence: 9 givenname: A. surname: Ogata fullname: Ogata, A. – sequence: 10 givenname: H. surname: Kamimura fullname: Kamimura, H. |
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Keywords | Flame retardant Mice Liver lesion Lipid metabolism Tetrabromobisphenol A Digestive system Liver Rodentia Lipids Metabolism Prenatal Vertebrata Mammalia Postnatal Mouse Animal Lesion |
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SubjectTerms | Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biological and medical sciences Blood Glucose - metabolism Blood Urea Nitrogen Body Weight - drug effects Cholesterol - blood Female Flame retardant Flame Retardants - pharmacology Kidney - anatomy & histology Kidney - drug effects Kidney - pathology Lipid metabolism Litter Size - drug effects Liver - anatomy & histology Liver - drug effects Liver - pathology Liver lesion Male Maternal Exposure Medical sciences Mice Mice, Inbred ICR Organ Size - drug effects Polybrominated Biphenyls - pharmacology Pregnancy Prenatal Exposure Delayed Effects Tetrabromobisphenol A Toxicology Triglycerides - blood |
Title | Effects of tetrabromobisphenol A, brominated flame retardant, in ICR mice after prenatal and postnatal exposure |
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