Comparative Analyses of mTOR/Akt and Muscle Atrophy-Related Signaling in Aged Respiratory and Gastrocnemius Muscles

• Published in: International journal of molecular sciences Vol. 21; no. 8; p. 2862
• Main Authors: Kim, Kun Woo, Cho, Hye-Jeong, Khaliq, Sana Abdul, Son, Kuk Hui, Yoon, Mee-Sup
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.04.2020; MDPI
• Subjects: Age; Aging; Aging - metabolism; AKT protein; Animals; Atrophy; Autophagy; Autophagy - genetics; Biomarkers; Chronic obstructive pulmonary disease; Diaphragm; Diaphragms; Disease Models, Animal; Forkhead protein; FOXO1 protein; gastrocnemii; Gene Expression; Homeostasis; intercostal muscles; Intercostal Muscles - metabolism; Kinases; Mammals; Metabolism; Mitochondria; Mitochondria, Muscle - genetics; Mitochondria, Muscle - metabolism; muscle atrophy; Muscle function; Muscle, Skeletal - metabolism; Muscles; Muscular Atrophy - genetics; Muscular Atrophy - metabolism; Muscular Atrophy - pathology; Phagocytosis; Phosphorylation; Proteasomes; Protein synthesis; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Quality control; Rats; Respiratory Muscles - metabolism; Sarcopenia; Signal Transduction; Skeletal muscle; TOR protein; TOR Serine-Threonine Kinases - metabolism; Transcription factors; Ubiquitin; Ubiquitin - genetics; Ubiquitin - metabolism; diaphragm; autophagy; gastrocnemii; muscle atrophy; intercostal muscles; sarcopenia

Sarcopenia is the degenerative loss of skeletal muscle mass and function associated with aging and occurs in the absence of any underlying disease or condition. A comparison of the age-related molecular signaling signatures of different muscles has not previously been reported. In this study, we com...