Exosomal long non-coding RNA-LINC00839 promotes lung adenocarcinoma progression by activating NF-κB signaling pathway

• Published in: Annals of medicine (Helsinki) Vol. 56; no. 1; p. 2430029
• Main Authors: Sun, Yue, Zhen, Fang, Wang, Hongyi, Liang, Xiao, Wang, Yaru, Wang, Feiran, Hu, Jing
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2024; Taylor & Francis Group
• Subjects: Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - metabolism; Adenocarcinoma of Lung - pathology; Animals; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Disease Progression; Exosomes - genetics; Exosomes - metabolism; Gene Expression Regulation, Neoplastic; Humans; LINC00839; lung adenocarcinoma; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miR-17-5p; NF-kappa B - metabolism; NF-κB p65; nuclear translocation; Oncology; PTBP1; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction - genetics; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; LINC00839; miR-17-5p; PTBP1; NF-κB p65; nuclear translocation; lung adenocarcinoma

Lung adenocarcinoma is the most common type of lung cancer, accounting for approximately 40% of all lung cancer cases, and has the highest incidence among lung cancer subtypes. Recent studies have suggested that long non-coding RNAs (lncRNAs) play a crucial role in the initiation and progression of...