The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice - Hong, Liang-Jian; Chen, Ai-Jun; Li, Feng-Zeng; Chen, Ke-Jun; Fang, Sheng (Drug design, development and therapy, 2020)
Keywords: 1-Phosphatidylinositol 3-kinase; 17-aag; activation; akt; AKT protein; Animals; Antibodies; Beads; Benzoquinones - chemistry; Benzoquinones - pharmacology; Cell activation; Cell culture; Cell cycle; Cell Proliferation - drug effects; Chronic conditions; Deposition; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flow cytometry; Glycogen Synthase Kinase 3 beta - antagonists & inhibitors; Glycogen Synthase Kinase 3 beta - metabolism; Heat shock proteins; Histopathology; hsp90; HSP90 Heat-Shock Proteins - antagonists & inhibitors; HSP90 Heat-Shock Proteins - metabolism; Hsp90 protein; Inhibitors; Kidneys; Laboratory animals; Lactams, Macrocyclic - chemistry; Lactams, Macrocyclic - pharmacology; Lupus; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred MRL lpr; Molecular Structure; Original Research; Proteins; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - metabolism; Signal transduction; Signal Transduction - drug effects; Signaling; Stains & staining; Statistical analysis; Structure-Activity Relationship; Systemic lupus erythematosus; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Western blotting; HSP90; 17-AAG; AKT; activation; lupus