Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders

• Published in: International journal of molecular sciences Vol. 19; no. 1; p. 247
• Main Authors: Moskot, Marta, Bocheńska, Katarzyna, Jakóbkiewicz-Banecka, Joanna, Banecki, Bogdan, Gabig-Cimińska, Magdalena
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.01.2018; MDPI
• Subjects: Animals; Atopic dermatitis; Dermatitis; Disease Susceptibility; Drug therapy; Eczema; Flavonoids - pharmacology; Flavonoids - therapeutic use; Humans; Inflammatory diseases; Lipid Metabolism - drug effects; Lysosomal storage diseases; Lysosomal Storage Diseases - etiology; Lysosomal Storage Diseases - metabolism; Lysosomal Storage Diseases - therapy; Metabolic disorders; Metabolic pathways; Metabolic Syndrome - etiology; Metabolic Syndrome - metabolism; Metabolism; Pathogenesis; Pharmacology; Psoriasis; Review; Signal Transduction; Skin diseases; Skin Diseases - etiology; Skin Diseases - metabolism; Skin Diseases - therapy; skin disorders; sphingolipid metabolism alterations; Sphingolipids; Sphingolipids - metabolism; treatments; workable therapies; workable therapies; inflammatory diseases; lysosomal storage diseases; sphingolipid metabolism alterations; treatments; skin disorders

Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many infl...