Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder

• Published in: Psychiatry research Vol. 235; pp. 38 - 42
• Main Authors: Tsai, Meng-Chang, Huang, Tiao-Lai
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30.01.2016
• Subjects: Adult; Biomarkers - blood; Case-Control Studies; CAT; Catalase - blood; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - blood; Depression; Depressive Disorder, Major - blood; Depressive Disorder, Major - enzymology; Female; Glutathione Peroxidase - blood; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress - physiology; Protein Carbonylation; Psychiatry; S100 Calcium Binding Protein beta Subunit - blood; S100B; SOD; Superoxide Dismutase - blood; Thiobarbituric Acid Reactive Substances - metabolism; SOD; Depression; S100B; CAT

Oxidative stress may play an important role in the pathophysiology of major depressive disorder (MDD). The aim of this study was to investigate the serum levels of oxidative stress biomarkers and S100B in patients with MDD in an acute phase, and evaluate the changes in superoxide dismutase (SOD), pr...