Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome

• Published in: International journal of molecular sciences Vol. 18; no. 5; p. 928
• Main Authors: Mirzayans, Razmik, Andrais, Bonnie, Kumar, Piyush, Murray, David
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.04.2017; MDPI
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Antineoplastic Agents - toxicity; Apoptosis; Apoptosis - drug effects; Cell cycle; Cell Cycle Checkpoints - drug effects; Cellular Senescence - drug effects; Chemotherapy; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Deoxyribonucleic acid; DNA; DNA Damage - drug effects; HSP40 Heat-Shock Proteins - genetics; HSP40 Heat-Shock Proteins - metabolism; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Review; Signal Transduction - drug effects; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; mutational processes; multinucleated giant cells; chemical genotoxic agents; DNAJB9; apoptosis; p53 signaling; premature senescence; p21WAF1 (CDKN1A)

Our genomes are subject to potentially deleterious alterations resulting from endogenous sources (e.g., cellular metabolism, routine errors in DNA replication and recombination), exogenous sources (e.g., radiation, chemical agents), and medical diagnostic and treatment applications. Genome integrity...