IL10 rs1800872 Is Associated with Non-Steroidal Anti-Inflammatory Drugs Exacerbated Respiratory Disease in Mexican-Mestizo Patients

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 1; p. 104
• Main Authors: Pavón-Romero, Gandhi Fernando, Pérez-Rubio, Gloria, Ramírez-Jiménez, Fernando, Ambrocio-Ortiz, Enrique, Merino-Camacho, Cristian Rubén, Falfán-Valencia, Ramcés, Teran, Luis M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.01.2020; MDPI
• Subjects: Adult; Alleles; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Aspirin; Asthma; Asthma - drug therapy; Asthma - physiopathology; Case-Control Studies; Female; Gene Frequency - genetics; Gene mapping; Genes; genetic association; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genomes; Genotype; Humans; Hypersensitivity; il10; Interleukin 1; Interleukin 10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Male; Mexico - epidemiology; Middle Aged; n-erd; Nonsteroidal anti-inflammatory drugs; Peroxisome proliferator-activated receptors; Polymorphism, Single Nucleotide - genetics; Polyps; Respiratory diseases; Respiratory Distress Syndrome - drug therapy; Respiratory Distress Syndrome - genetics; Respiratory Tract Diseases - drug therapy; Respiratory Tract Diseases - genetics; Respiratory Tract Diseases - physiopathology; Single-nucleotide polymorphism; snp; Software; Mexico; United States > US; Germany; IL10; N-ERD; genetic association; SNP
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom10010104

Non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (N-ERD) is a disease integrated by asthma, nasal polyps, and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAID). Genetic association studies have explored single nucleotide polymorphisms (SNPs) in genes involved in theoretical pathophysiological mechanisms, but most of these lack replication of findings in second populations. Our objective was to evaluate the association of SNPs in candidate genomic regions described in Asian and European subjects with N-ERD in Mexican-mestizo patients. We designed a replicative study in two stages. We included 381 SNPs selected by fine mapping of associated genes in a microarray, which were tested in three groups: N-ERD (N), asthma (A), and control group (CG); by means of GoldenGate array, positive results by genetic models were validated in the second stage in another population through qPCR with the same methodology. In the allelic model, we identified 11 SNPs in N vs. CG comparison, and five in N vs. A and A vs. CG, respectively. By genetics models, all SNPs in , rs13239058 in , and rs1554286 and rs1800872 in were associated in both models. In the second stage, only rs1800872CC showed an association in the dominant model comparing N vs. GC, = 0.004, OR = 0.44. In conclusion, rs1800872 in was the only associated with N-ERD in Mexican-mestizo patients.