Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment

Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Seve...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 21; p. 5315
Main Authors Yu, Hui-I, Shen, Hui-Ching, Chen, Shu-Hsin, Lim, Yun-Ping, Chuang, Hsiang-Hsun, Tai, Tsai-Sung, Kung, Fang-Ping, Lu, Chieh-Hsiang, Hou, Chia-Yi, Lee, Ying-Ray
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.10.2019
MDPI
Subjects
Apoptosis
Autophagic Cell Death - drug effects
Autophagy
Bone cancer
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell growth
Cell Line, Tumor
Cytotoxicity
Homeostasis
Humans
Investigations
MAP Kinase Signaling System - drug effects
Multiple myeloma
Neoplasm Proteins - metabolism
Physiology
Piperidines - pharmacology
Prostate
Sarcoma
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Tumorigenesis
thyroid cancer
aloperine
autophagy
Online AccessGet full text

Cover

Abstract Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.
AbstractList Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.
Aloperine, an alkaloid isolated from , exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.
Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.
Aloperine, an alkaloid isolated from Sophora alopecuroides , exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells.
Author Chen, Shu-Hsin
Kung, Fang-Ping
Yu, Hui-I
Lim, Yun-Ping
Chuang, Hsiang-Hsun
Lee, Ying-Ray
Shen, Hui-Ching
Hou, Chia-Yi
Tai, Tsai-Sung
Lu, Chieh-Hsiang
AuthorAffiliation 3 Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan; 10472@cych.org.tw
4 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; limyp@mail.cmu.edu.tw
1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan; 04490@cych.org.tw (H.-I.Y.); 04486@cych.org.tw (H.-H.C.); 04015@cych.org.tw (T.-S.T.); 07266@cych.org.tw (F.-P.K.); 02602@cych.org.tw (C.-H.L.)
2 Department of Clinical Pathology, Chi Mei Medical Center, Liouying 736 Taiwan; huiching0105@gmail.com (H.-C.S.); 960360@mail.chimei.org.tw (C.-Y.H.)
AuthorAffiliation_xml – name: 3 Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan; 10472@cych.org.tw
– name: 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan; 04490@cych.org.tw (H.-I.Y.); 04486@cych.org.tw (H.-H.C.); 04015@cych.org.tw (T.-S.T.); 07266@cych.org.tw (F.-P.K.); 02602@cych.org.tw (C.-H.L.)
– name: 4 Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; limyp@mail.cmu.edu.tw
– name: 2 Department of Clinical Pathology, Chi Mei Medical Center, Liouying 736 Taiwan; huiching0105@gmail.com (H.-C.S.); 960360@mail.chimei.org.tw (C.-Y.H.)
Author_xml – sequence: 1
  givenname: Hui-I
  surname: Yu
  fullname: Yu, Hui-I
– sequence: 2
  givenname: Hui-Ching
  surname: Shen
  fullname: Shen, Hui-Ching
– sequence: 3
  givenname: Shu-Hsin
  surname: Chen
  fullname: Chen, Shu-Hsin
– sequence: 4
  givenname: Yun-Ping
  surname: Lim
  fullname: Lim, Yun-Ping
– sequence: 5
  givenname: Hsiang-Hsun
  surname: Chuang
  fullname: Chuang, Hsiang-Hsun
– sequence: 6
  givenname: Tsai-Sung
  surname: Tai
  fullname: Tai, Tsai-Sung
– sequence: 7
  givenname: Fang-Ping
  surname: Kung
  fullname: Kung, Fang-Ping
– sequence: 8
  givenname: Chieh-Hsiang
  surname: Lu
  fullname: Lu, Chieh-Hsiang
– sequence: 9
  givenname: Chia-Yi
  surname: Hou
  fullname: Hou, Chia-Yi
– sequence: 10
  givenname: Ying-Ray
  orcidid: 0000-0002-0349-0960
  surname: Lee
  fullname: Lee, Ying-Ray
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31731481$$D View this record in MEDLINE/PubMed
BookMark eNptkUtrGzEUhUVJaOK0u66LoJss4kTPGc2mYExekJAu3LXQSBpbRiO50kyL_32Ul3FCV7qg7557zz0TcBBisAB8w-ic0gZduHWfCSKYU8w_gWPMCJkiVNUHe_URmOS8RohQwpvP4IjimmIm8DH4NRuHuFmp5RbeRzN6NbgYoAvwZuxVgIvVNkVn4FwFbROcW-8z7KL38Z8LSzjzcWOTCxYuklVDb8PwBRx2ymf79fU9Ab-vLhfzm-ndw_XtfHY31awWw9Q0yCBW16JWguqGaIoMNx21jGJSt9pw3baMdIa3AjUUVxozjhC2FGnb2ZaegJ8vupux7a3RZXRSXm6S61XayqicfP8T3Eou419ZiYpUXBSB01eBFP-MNg-yd1kXgyrYOGZJyj0xYpUgBf3xAV3HMYViTxLORFXhGuNCfd_faLfK27ELcPYC6BRzTrbbIRjJpyzlfpYFJx9w7YbnfIof5__f9AjDg6Kk
CitedBy_id crossref_primary_10_3390_ijms24098048
crossref_primary_10_1007_s10555_023_10119_w
crossref_primary_10_3390_ijms21114081
crossref_primary_10_2147_OTT_S260215
crossref_primary_10_3390_ijms22189864
crossref_primary_10_1155_2020_1303524
crossref_primary_10_1210_endocr_bqae030
crossref_primary_10_62347_DNTG2917
crossref_primary_10_62347_MINX1330
crossref_primary_10_1186_s43556_023_00155_x
crossref_primary_10_3390_biomedicines10040905
crossref_primary_10_3390_ijms25105395
crossref_primary_10_3390_molecules27196474
crossref_primary_10_1507_endocrj_EJ22_0017
crossref_primary_10_14348_molcells_2022_2242
crossref_primary_10_1007_s12672_025_01815_w
crossref_primary_10_1186_s12885_024_12715_7
crossref_primary_10_2147_DDDT_S288473
crossref_primary_10_1016_j_intimp_2021_107720
crossref_primary_10_2174_0109298665335370241017055831
crossref_primary_10_1080_07357907_2023_2183027
crossref_primary_10_3892_or_2022_8368
Cites_doi 10.2174/0929867324666170206142658
10.1016/j.ejmech.2017.12.002
10.1016/j.kint.2015.11.021
10.1016/j.phymed.2019.152843
10.1016/j.ejphar.2009.12.007
10.1016/j.febslet.2007.01.096
10.1186/s13045-015-0120-x
10.1007/s11418-015-0928-2
10.1002/path.2697
10.3892/ijmm.2014.1718
10.1172/JCI73937
10.1021/acsmedchemlett.7b00376
10.1016/j.ejmech.2018.02.061
10.1016/j.biopha.2017.02.033
10.1021/jf103581r
10.1080/15548627.2015.1100356
10.4161/auto.4451
10.1158/0008-5472.CAN-13-2966
10.2147/OTT.S165262
10.1038/s41419-019-1340-8
10.2119/molmed.2015.00056
10.1038/s41598-018-24565-y
10.1016/j.ebiom.2019.01.054
10.3389/fonc.2014.00064
10.1021/acsmedchemlett.5b00339
10.3892/etm.2016.3962
10.1016/j.biopha.2017.09.066
10.1111/j.1742-7843.2010.00653.x
10.3390/ijms19010312
10.1101/gad.1599207
10.1038/nrm3735
ContentType Journal Article
Copyright 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2019 by the authors. 2019
Copyright_xml – notice: 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2019 by the authors. 2019
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
DOI 10.3390/ijms20215315
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE
MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID PMC6862658
31731481
10_3390_ijms20215315
Genre Journal Article
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESX
F5P
FRP
FYUFA
GNUQQ
GUQSH
GX1
HH5
HMCUK
HYE
IAO
IHR
ITC
KQ8
LK8
M1P
M2O
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RPM
TR2
TUS
UKHRP
~8M
3V.
ABJCF
BBNVY
BHPHI
CGR
CUY
CVF
ECM
EIF
GROUPED_DOAJ
HCIFZ
KB.
M7P
M~E
NPM
PDBOC
7XB
8FK
K9.
MBDVC
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
Q9U
7X8
5PM
ID FETCH-LOGICAL-c478t-d90d047787a83c92c30d5df3e43127bcd5cbb42fd5b809316c145001e30cefeb3
IEDL.DBID M48
ISSN 1422-0067
1661-6596
IngestDate Thu Aug 21 14:10:55 EDT 2025
Fri Jul 11 10:44:24 EDT 2025
Fri Jul 25 20:34:20 EDT 2025
Wed Feb 19 02:30:46 EST 2025
Tue Jul 01 01:45:59 EDT 2025
Thu Apr 24 23:02:17 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 21
Keywords thyroid cancer
aloperine
autophagy
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-d90d047787a83c92c30d5df3e43127bcd5cbb42fd5b809316c145001e30cefeb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
These authors contributed equally to this work.
Hsiang-Hsun Chuang had passed away.
ORCID 0000-0002-0349-0960
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms20215315
PMID 31731481
PQID 2548661711
PQPubID 2032341
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6862658
proquest_miscellaneous_2315104682
proquest_journals_2548661711
pubmed_primary_31731481
crossref_primary_10_3390_ijms20215315
crossref_citationtrail_10_3390_ijms20215315
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20191025
PublicationDateYYYYMMDD 2019-10-25
PublicationDate_xml – month: 10
  year: 2019
  text: 20191025
  day: 25
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2019
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Ren (ref_10) 2017; 13
Kaushal (ref_32) 2016; 89
Zhang (ref_16) 2018; 149
Wang (ref_29) 2015; 2015
Ling (ref_18) 2018; 11
Marino (ref_30) 2014; 15
Porta (ref_31) 2014; 4
Chen (ref_12) 2018; 97
Klionsky (ref_23) 2016; 12
Hu (ref_8) 2016; 21
ref_15
Liu (ref_26) 2019; 61
Suzuki (ref_21) 2007; 581
Zhao (ref_33) 2019; 10
Dang (ref_9) 2016; 7
Zhang (ref_1) 2014; 33
Glick (ref_27) 2010; 221
Gewirtz (ref_28) 2014; 74
Yuan (ref_3) 2010; 629
Dang (ref_13) 2017; 8
Tian (ref_19) 2018; 18
Lin (ref_4) 2011; 108
Ma (ref_6) 2015; 69
Wu (ref_11) 2017; 89
Ebrahimi (ref_25) 2017; 24
Yin (ref_17) 2018; 8
Kimura (ref_34) 2007; 3
Zhang (ref_14) 2018; 143
Zhou (ref_2) 1989; 10
Lin (ref_5) 2011; 59
Mizushima (ref_22) 2007; 21
Xia (ref_24) 2015; 125
Zhang (ref_20) 2019; 40
Wang (ref_7) 2015; 8
References_xml – volume: 10
  start-page: 360
  year: 1989
  ident: ref_2
  article-title: Anti-Inflammatory and Anti-Allergic Action of Aloperine
  publication-title: Zhongguo Yao Li Xue Bao
– volume: 24
  start-page: 1321
  year: 2017
  ident: ref_25
  article-title: Targeting the Akt/Pi3k Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867324666170206142658
– volume: 143
  start-page: 1053
  year: 2018
  ident: ref_14
  article-title: Discovery and Evolution of Aloperine Derivatives as a New Family of Hcv Inhibitors with Novel Mechanism
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2017.12.002
– volume: 89
  start-page: 779
  year: 2016
  ident: ref_32
  article-title: Autophagy in Acute Kidney Injury
  publication-title: Kidney Int.
  doi: 10.1016/j.kint.2015.11.021
– volume: 61
  start-page: 152843
  year: 2019
  ident: ref_26
  article-title: Aloperine Induces Apoptosis and G2/M Cell Cycle Arrest in Hepatocellular Carcinoma Cells through the Pi3k/Akt Signaling Pathway
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2019.152843
– volume: 18
  start-page: 3699
  year: 2018
  ident: ref_19
  article-title: Aloperine Inhibits Proliferation, Migration and Invasion and Induces Apoptosis by Blocking the Ras Signaling Pathway in Human Breast Cancer Cells
  publication-title: Mol. Med. Rep.
– volume: 629
  start-page: 147
  year: 2010
  ident: ref_3
  article-title: Effects and Mechanisms of Aloperine on 2, 4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Balb/C Mice
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2009.12.007
– volume: 581
  start-page: 2156
  year: 2007
  ident: ref_21
  article-title: Molecular Machinery of Autophagosome Formation in Yeast, Saccharomyces Cerevisiae
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2007.01.096
– volume: 8
  start-page: 26
  year: 2015
  ident: ref_7
  article-title: Aloperine Executes Antitumor Effects against Multiple Myeloma through Dual Apoptotic Mechanisms
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-015-0120-x
– volume: 69
  start-page: 575
  year: 2015
  ident: ref_6
  article-title: Protective Effects of Aloperine on Neonatal Rat Primary Cultured Hippocampal Neurons Injured by Oxygen-Glucose Deprivation and Reperfusion
  publication-title: J. Nat. Med.
  doi: 10.1007/s11418-015-0928-2
– volume: 221
  start-page: 3
  year: 2010
  ident: ref_27
  article-title: Autophagy: Cellular and Molecular Mechanisms
  publication-title: J. Pathol.
  doi: 10.1002/path.2697
– volume: 33
  start-page: 1613
  year: 2014
  ident: ref_1
  article-title: Aloperine Induces G2/M Phase Cell Cycle Arrest and Apoptosis in Hct116 Human Colon Cancer Cells
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2014.1718
– volume: 125
  start-page: 5
  year: 2015
  ident: ref_24
  article-title: Pharmacologic Agents Targeting Autophagy
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI73937
– volume: 8
  start-page: 1199
  year: 2017
  ident: ref_13
  article-title: Structure Optimization of Aloperine Derivatives as Hiv-1 Entry Inhibitors
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/acsmedchemlett.7b00376
– volume: 149
  start-page: 45
  year: 2018
  ident: ref_16
  article-title: Discovery and Evolution of Aloperine Derivatives as Novel Anti-Filovirus Agents through Targeting Entry Stage
  publication-title: Eur. J. Med. Chem.
  doi: 10.1016/j.ejmech.2018.02.061
– volume: 89
  start-page: 632
  year: 2017
  ident: ref_11
  article-title: Protective Effects of Aloperine on Monocrotaline-Induced Pulmonary Hypertension in Rats
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2017.02.033
– volume: 59
  start-page: 184
  year: 2011
  ident: ref_5
  article-title: Five Bitter Compounds Display Different Anti-Inflammatory Effects through Modulating Cytokine Secretion Using Mouse Primary Splenocytes in Vitro
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf103581r
– volume: 12
  start-page: 1
  year: 2016
  ident: ref_23
  article-title: Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition)
  publication-title: Autophagy
  doi: 10.1080/15548627.2015.1100356
– volume: 2015
  start-page: 934207
  year: 2015
  ident: ref_29
  article-title: Elaborating the Role of Natural Products-Induced Autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art
  publication-title: BioMed Res. Int.
– volume: 3
  start-page: 452
  year: 2007
  ident: ref_34
  article-title: Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged Lc3
  publication-title: Autophagy
  doi: 10.4161/auto.4451
– volume: 74
  start-page: 647
  year: 2014
  ident: ref_28
  article-title: The Four Faces of Autophagy: Implications for Cancer Therapy
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-2966
– volume: 11
  start-page: 2735
  year: 2018
  ident: ref_18
  article-title: Aloperine Executes Antitumor Effects through the Induction of Apoptosis and Cell Cycle Arrest in Prostate Cancer in Vitro and in Vivo
  publication-title: Onco Targets Ther.
  doi: 10.2147/OTT.S165262
– volume: 10
  start-page: 127
  year: 2019
  ident: ref_33
  article-title: Autophagic Flux Blockage in Alveolar Epithelial Cells Is Essential in Silica Nanoparticle-Induced Pulmonary Fibrosis
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-1340-8
– volume: 21
  start-page: 912
  year: 2016
  ident: ref_8
  article-title: Aloperine Protects Mice against Ischemia-Reperfusion (Ir)-INDUCED Renal Injury by Regulating Pi3k/Akt/Mtor Signaling and Ap-1 Activity
  publication-title: Mol. Med.
  doi: 10.2119/molmed.2015.00056
– volume: 8
  start-page: 6265
  year: 2018
  ident: ref_17
  article-title: Aloperine Protects Mice against Bleomycin-Induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-24565-y
– volume: 40
  start-page: 151
  year: 2019
  ident: ref_20
  article-title: Sa-49, a Novel Aloperine Derivative, Induces Mitf-Dependent Lysosomal Degradation of Pd-L1
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.01.054
– volume: 4
  start-page: 64
  year: 2014
  ident: ref_31
  article-title: Targeting Pi3k/Akt/Mtor Signaling in Cancer
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2014.00064
– volume: 7
  start-page: 240
  year: 2016
  ident: ref_9
  article-title: Aloperine and Its Derivatives as a New Class of Hiv-1 Entry Inhibitors
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/acsmedchemlett.5b00339
– volume: 13
  start-page: 315
  year: 2017
  ident: ref_10
  article-title: Aloperine Attenuates Hydrogen Peroxide-Induced Injury Via Anti-Apoptotic Activity and Suppression of the Nuclear Factor-Kappab Signaling Pathway
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2016.3962
– volume: 97
  start-page: 45
  year: 2018
  ident: ref_12
  article-title: Aloperine Induces Apoptosis and Inhibits Invasion in Mg-63 and U2os Human Osteosarcoma Cells
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2017.09.066
– volume: 108
  start-page: 304
  year: 2011
  ident: ref_4
  article-title: In Vitro Anti-Tumour Activities of Quinolizidine Alkaloids Derived from Sophora Flavescens Ait
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/j.1742-7843.2010.00653.x
– ident: ref_15
  doi: 10.3390/ijms19010312
– volume: 21
  start-page: 2861
  year: 2007
  ident: ref_22
  article-title: Autophagy: Process and Function
  publication-title: Genes Dev.
  doi: 10.1101/gad.1599207
– volume: 15
  start-page: 81
  year: 2014
  ident: ref_30
  article-title: Self-Consumption: The Interplay of Autophagy and Apoptosis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3735
SSID ssj0023259
Score 2.4006584
Snippet Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant,...
Aloperine, an alkaloid isolated from , exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive,...
Aloperine, an alkaloid isolated from Sophora alopecuroides , exhibits multiple pharmacological activities including anti-inflammatory, antioxidant,...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 5315
SubjectTerms Apoptosis
Autophagic Cell Death - drug effects
Autophagy
Bone cancer
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell growth
Cell Line, Tumor
Cytotoxicity
Homeostasis
Humans
Investigations
MAP Kinase Signaling System - drug effects
Multiple myeloma
Neoplasm Proteins - metabolism
Physiology
Piperidines - pharmacology
Prostate
Sarcoma
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Tumorigenesis
SummonAdditionalLinks – databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEBZpQqGX0iZ9bJoWFZJTELFelnwqy9JtKCT0sIHcjCzJzYatvd0HYf99Z2yvu2lpzxphMyNpvtGM5iPkVGDqzXDFlPeCKSMly3TUTAaLkMK5sundeXWdXt6or7f6trtwW3ZlldszsTmoQ-3xjvwCAhkLvsRw_mn-kyFrFGZXOwqNJ-SAg6fBki47_tIHXFI0ZGkc5rFUZ2lb-C4hzL-Y3v9YCvR3Eglxd13SXzjzz3LJHf8zfkGed8CRDltLvyR7sTokT1sqyc0R-TZcY4sA931Dr-rQcXLRaUWbW3o6udss6mmgIzTygo7ibLakJayB-gF8Fx3O6nnzDpBOtoXnr8jN-PNkdMk6tgTmlbErFrIkJKB3a5yVPhNeJkGHUkaACMIUPmhfFEqUQRc2ySRPPVcazBFl4mMJMfVrsl_VVXxLqCm1id5kVpcO4FTqPOfSO5MGF1Si3ICcbxWW-66VODJazHIIKVC9-a56B-Ssl563LTT-IXey1X3ebaRl_tvsA_KxH4YtgHkNV8V6DTIwGVPVVgzIm9ZU_YcAHkmI-GC2eWTEXgDbaz8eqaZ3TZttfDsD-Oz4_7_1jjwDDJWhOxP6hOyvFuv4HnDKqvjQLMZf1jbnZQ
  priority: 102
  providerName: ProQuest
Title Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/31731481
https://www.proquest.com/docview/2548661711
https://www.proquest.com/docview/2315104682
https://pubmed.ncbi.nlm.nih.gov/PMC6862658
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB7ShJZcSpO-3KSLCsmpuLUtaSUfStku2YbChhB2YW9GluRmi2un-6Ddf5-RX2Sb9NKLLxohmE_i-8YjzQCcRC71JkLmM60jnwlK_Zhb7lMjnaRQKqtqd44v-udT9m3GZzvQdhttHLh8MLRz_aSmi_zDn1-bz3jgP7mIE0P2j_MfP5eR4y7qXpvvIScJ18tgzLp8AsoGHtfX3u_N2IcnyKEUw4Jwm5vuCc6_703eIaLRM3jaKEgyqCE_gB1bHMLjuqfk5jlcDtauVoD6viHj0jTNuci8INXvejK53izKuSFDh_aCDG2eL0mGm6H8jSRGBnl5Uz0IJJP2BvoLmI7OJsNzv2mb4Gsm5Mo3cWACBEAKJamOI00Dw01GLWqFSKTacJ2mLMoMT2UQ07CvQ8YRF0sDbTMMrl_CblEW9jUQkXFhtYglzxTqqr7SYUi1En2jDAuY8uB967BENzXFXWuLPMHYwnk6uetpD04765u6lsY_7I5b3yfthkgwkJWoJUQYevCuG8az4BIcqrDlGm1wsstZy8iDVzVU3UItxh6ILRA7A1dne3ukmF9X9bbdIxoUam_-e-YR7KPOih3lRfwYdleLtX2LWmaV9uCRmAn8ytHXHux9Obu4vOo5duG9agPfAkB7-co
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxLMsFDASPSGriR9xckBotbBsabfisJV6C47t0EVLsuxD1f4pfiPjvNiC4NZzxsloPPbMZB4fwGvmU28qFFQYw6hQnNNEOkm5jb1LoXVeze4cn0ajM_HpXJ7vwM-2F8aXVbZ3YnVR29L4f-SHGMjEaEtUGL6b_6AeNcpnV1sIjVotjt3mEkO25duj97i_B4wNP0wGI9qgClAjVLyiNglsgPzFSsfcJMzwwEqbc4emlKnMWGmyTLDcyizGcD-MTCgksu14YFyOsSe-9wbcFBwtue9MH37sAjzOKnC2EPmkkUyiutAeCYPD6bfvS-btK_cAvNsm8C-_9s_yzC17N7wHdxtHlfRrzboPO654ALdq6MrNQ_jcX_uRBPrrhoxL22CAkWlBqqwAmVxsFuXUkoFXqgUZuNlsSXLUufISbSXpz8p51XdIJm2h-yM4uxY5PobdoizcEyAql8oZlcQy1-i-RdqEITdaRVZbEQjdgzetwFLTjC73CBqzFEMYL950W7w9OOio5_XIjn_Q7beyT5uDu0x_q1kPXnWP8cj5PIouXLlGGlzsU-Mx68FevVXdh9Ad4xhh4mp1ZRM7Aj_O--qTYnpRjfX2vTroDz79P1sv4fZoMj5JT45Oj5_BHfTfEm9KmdyH3dVi7Z6jj7TKXlSKSeDLdZ-EX1PWJGQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTiBeEJ-jMMBI7AlZTew4Th4QKt2qjbGqQp20t-DYDisqSemHpv5r_HWc80UHgrc9-5w45zvf_XLnO4A3zIXepB_QQGtGA8k5jYUVlJvIuRRKZWXtzrNReHwefLwQFzvws7kL49IqmzOxPKhNod0_8h4CmQhtifT9XlanRYwPh-_nP6jrIOUirU07jUpETu3mCuHb8t3JIe71AWPDo8ngmNYdBqgOZLSiJvaMh2uNpIq4jpnmnhEm4xbNKpOpNkKnacAyI9IIob8faj8Q-AmWe9pmiEPxubdgVzpU1IHdD0ej8ecW7nFWtmrzcdU0FHFYpd1zHnu96bfvS-asLXfteLcN4l9e7p_JmlvWb3gf7tVuK-lXcvYAdmz-EG5XjSw3j2DcX7sCBerrhpwVpu4IRqY5KWMEZHK5WRRTQwZOxBZkYGezJclQAosrtJykPyvm5S1EMmnS3h_D-Y1w8gl08iK3T4HITEirZRyJTKEzFyrt-1wrGRplAi9QXXjbMCzRdSFz109jliCgcexNttnbhYOWel4V8PgH3X7D-6RW42XyW-i68LodRgV0URWV22KNNDjZBcoj1oW9aqvaF6FzxhFv4mx5bRNbAlfc-_pIPr0si3y7mzvoHT77_7JewR3UguTTyej0OdxFZy52dpWJfeisFmv7Ah2mVfqylkwCX25aGX4Borop9g
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Autophagy+Modulation+in+Human+Thyroid+Cancer+Cells+following+Aloperine+Treatment&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Yu%2C+Hui-I&rft.au=Shen%2C+Hui-Ching&rft.au=Chen%2C+Shu-Hsin&rft.au=Lim%2C+Yun-Ping&rft.date=2019-10-25&rft.pub=MDPI&rft.eissn=1422-0067&rft.volume=20&rft.issue=21&rft_id=info:doi/10.3390%2Fijms20215315&rft_id=info%3Apmid%2F31731481&rft.externalDocID=PMC6862658
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon