The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

• Published in: International journal of molecular sciences Vol. 20; no. 13; p. 3328
• Main Authors: Kelley, Nathan, Jeltema, Devon, Duan, Yanhui, He, Yuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.07.2019; MDPI
• Subjects: Animals; Apoptosis; Cytokines; Humans; Immune system; Inflammasomes - metabolism; Kinases; Ligands; Mitochondria - pathology; Mitochondrial DNA; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Pathogens; Phosphorylation; Protein Processing, Post-Translational; Proteins; Reactive Oxygen Species - metabolism; Review; Viral infections; NLRP3 regulators; Post-translational modification; Mitochondrial dysfunction; ROS; Ionic flux; Priming; NLRP3 inflammasome; Lysosomal damage

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant activation of the NLRP3 inflammasome has been linked...