Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 5; p. 1104
• Main Authors: Ortiz-Masiá, Dolores, Gisbert-Ferrándiz, Laura, Bauset, Cristina, Coll, Sandra, Mamie, Céline, Scharl, Michael, Esplugues, Juan V., Alós, Rafael, Navarro, Francisco, Cosín-Roger, Jesús, Barrachina, María D., Calatayud, Sara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2020; MDPI
• Subjects: Animals; Cadherins - metabolism; Cell adhesion & migration; Colon; Crohn Disease - drug therapy; Crohn Disease - genetics; Crohn Disease - metabolism; Crohn’s disease; E-cadherin; Epithelial cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Fibrosis; Fibrosis - drug therapy; Fibrosis - metabolism; Fistula; Fistula - drug therapy; Fistula - pathology; Fistulae; Hospitals; Humans; Inflammation - drug therapy; Inflammation - pathology; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Intestines - drug effects; Intestines - pathology; Mesenchyme; Proteins; Receptors, G-Protein-Coupled - drug effects; Software; succinate; Succinic Acid - metabolism; Succinic Acid - pharmacology; Vimentin; Wnt protein; Germany; Spain; succinate; fistula; Crohn’s disease

The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their relevance in EMT and Crohn’s disease (CD) fistula...