Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration

• Published in: International journal of molecular sciences Vol. 22; no. 8; p. 3945
• Main Authors: Geng, Fang, Ma, Jinmin, Li, Xueyu, Hu, Zhengyue, Zhang, Ruilin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2021; MDPI
• Subjects: Ablation; Animals; Binding sites; Cardiomyocytes; Gene expression; Heart; Heart Ventricles - metabolism; Hemodynamics; Myocardium - metabolism; Regeneration; Tissue engineering; Ventricular Function; Zebrafish; Zebrafish - genetics; Zebrafish - metabolism; regeneration-responsive enhancer; heart regeneration; Notch signaling; hemodynamics

Cardiac regenerative capacity varies widely among vertebrates. Zebrafish can robustly regenerate injured hearts and are excellent models to study the mechanisms of heart regeneration. Recent studies have shown that enhancers are able to respond to injury and regulate the regeneration process. Howeve...