Mouse Gastric Epithelial Cells Resist CagA Delivery by the Helicobacter pylori Type IV Secretion System

• Published in: International journal of molecular sciences Vol. 23; no. 5; p. 2492
• Main Authors: Shrestha, Rejina, Murata-Kamiya, Naoko, Imai, Satoshi, Yamamoto, Masami, Tsukamoto, Tetsuya, Nomura, Sachiyo, Hatakeyama, Masanori
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2022; MDPI
• Subjects: Adhesins, Bacterial - genetics; Adhesins, Bacterial - metabolism; Animals; Antibodies; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Bacterial infections; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cell adhesion & migration; Cricetinae; Cricetulus; Epithelial Cells - metabolism; Experiments; Gastric cancer; Genomes; Helicobacter Infections; Helicobacter pylori - metabolism; Hematology; Immunoglobulins; Infections; Kinases; Mice; Protein Transport; Proteins; Stomach; Type IV Secretion Systems - genetics; Type IV Secretion Systems - metabolism; HopQ; Helicobacter pylori; mouse gastric epithelial cells; CagA; CEACAM

The initial step in bacterial infection is adherence of the bacterium to the target cell surface. Helicobacter pylori exploits the interaction of bacterial adhesin protein HopQ with human epithelial CEACAMs (CEACAM1, 5, and 6) to stably adhere to gastric epithelial cells, which is necessary for deli...