Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application

Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify...

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Published inInternational journal of biological macromolecules Vol. 265; no. Pt 2; p. 130933
Main Authors Sousa, Pedro, Tavares-Valente, Diana, Pereira, Carla F., Pinto-Ribeiro, Inês, Azevedo-Silva, João, Madureira, Raquel, Ramos, Óscar L., Pintado, Manuela, Fernandes, João, Amorim, Manuela
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2024
Subjects
cell walls
circular economy
cytotoxicity
fermentation
genotoxicity
glucans
Glucans - chemistry
Glucans extraction
glucose
immunomodulators
ingredients
interleukin-6
interleukin-8
Polysaccharides - chemistry
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
safety assessment
Skin safety
Spent yeast
Water
water solubility
yeasts
Glucans extraction
Spent yeast
Skin safety
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Abstract Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy.
AbstractList Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy.Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy.
Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy.
Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this study focused on the extraction method to isolate and purify water-insoluble glucans from two different Saccharomyces cerevisiae strains: an engineered strain obtained from spent yeast in an industrial fermentation process and a wild strain produced through lab-scale fermentation. Two water-insoluble extracts with a high glucose content (> 90 %) were achieved and further subjected to a chemical modification using carboxymethylation to improve their water solubility. All the glucans' extracts, water-insoluble and carboxymethylated, were structurally and chemically characterized, showing almost no differences between both yeast-type strains. To ensure their safety for skin application, a broad safety assessment was undertaken, and no cytotoxic effect, immunomodulatory capacity (IL-6 and IL-8 regulation), genotoxicity, skin sensitization, and impact on the skin microbiota were observed. These findings highlight the potential of glucans derived from spent yeast as a sustainable and safe ingredient for cosmetic and skincare formulations, contributing to the sustainability and circular economy.
ArticleNumber 130933
Author Fernandes, João
Azevedo-Silva, João
Sousa, Pedro
Pereira, Carla F.
Pinto-Ribeiro, Inês
Tavares-Valente, Diana
Madureira, Raquel
Pintado, Manuela
Amorim, Manuela
Ramos, Óscar L.
Author_xml – sequence: 1
  givenname: Pedro
  surname: Sousa
  fullname: Sousa, Pedro
  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
– sequence: 2
  givenname: Diana
  surname: Tavares-Valente
  fullname: Tavares-Valente, Diana
  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
– sequence: 3
  givenname: Carla F.
  surname: Pereira
  fullname: Pereira, Carla F.
  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
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  fullname: Azevedo-Silva, João
  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
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  givenname: Raquel
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  fullname: Madureira, Raquel
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  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
– sequence: 8
  givenname: Manuela
  surname: Pintado
  fullname: Pintado, Manuela
  organization: Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
– sequence: 9
  givenname: João
  surname: Fernandes
  fullname: Fernandes, João
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– sequence: 10
  givenname: Manuela
  surname: Amorim
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  email: mamorim@ucp.pt
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Cites_doi 10.1074/jbc.275.16.11874
10.1155/2011/839682
10.3390/molecules25010057
10.3390/fib8010001
10.1016/S0304-4165(98)00137-8
10.3390/jof8030263
10.1038/nrmicro.2017.157
10.1016/j.onehlt.2016.02.002
10.3389/fmicb.2020.565549
10.1016/j.molimm.2003.10.007
10.1038/s41591-021-01383-w
10.1016/j.foodchem.2021.130708
10.1016/j.cellimm.2020.104146
10.1016/j.ijbiomac.2014.09.008
10.1016/j.it.2016.04.007
10.3390/ijms21238996
10.1016/j.tiv.2017.10.018
10.1016/j.carbpol.2019.01.090
10.3390/ijms20092337
10.1128/CMR.00034-18
10.1016/j.toxlet.2018.09.004
10.1016/j.carbpol.2014.06.050
10.3390/ijms22020825
10.3390/ijms13078142
10.1016/j.ijbiomac.2022.02.111
10.1016/j.tim.2019.01.008
10.1084/jem.20020470
10.1016/j.foodhyd.2015.07.003
10.1016/j.carbpol.2021.118826
10.1016/S0144-8617(03)00162-0
10.3390/ijms22094869
10.1128/MMBR.00038-05
10.1016/j.carbpol.2005.02.010
10.1016/j.foodhyd.2006.11.008
10.3390/ijms160921575
10.1016/j.carbpol.2016.01.003
10.1016/j.jff.2017.07.061
10.1007/s13258-021-01180-2
10.3390/molecules26082113
10.1046/j.1472-765X.2003.01394.x
10.3123/jemsge.31.47
10.1182/blood-2010-08-265892
10.3390/molecules27144616
10.3390/biomedicines8050101
10.1002/mnfr.201600356
10.3390/ijms23063156
10.1016/j.ijbiomac.2021.01.125
10.1016/j.carbpol.2014.03.010
10.1016/j.ijbiomac.2016.08.044
10.1002/1097-0061(20000630)16:9<857::AID-YEA561>3.0.CO;2-B
10.1111/j.1365-2621.2004.00742.x
10.1038/s41579-022-00780-3
10.1002/jat.3274
10.1016/j.carbpol.2004.09.003
10.1002/app.1993.070480801
10.3390/ijms24032389
10.1186/1756-8722-2-25
10.1080/14786410701591622
10.1016/j.ijbiomac.2023.123617
10.1016/j.carbpol.2015.02.031
10.3390/toxics10120740
10.1186/s13765-019-0428-2
10.1139/y59-099
10.1111/jdi.12165
10.1016/j.carbpol.2009.05.023
10.1177/1753425912447129
10.1016/j.chom.2017.07.002
10.1016/j.carbpol.2015.03.045
10.1007/s13596-011-0024-4
10.1111/j.1365-2621.2012.03181.x
10.3390/cosmetics8020050
10.1016/S0144-8617(98)00099-X
10.3390/molecules191220941
10.3390/microorganisms10122470
10.3390/ijms18040708
10.1007/s00217-013-2016-8
10.1111/j.1365-2958.2007.05872.x
10.3390/molecules23040806
10.1016/j.tcsw.2019.100022
10.1016/j.ijpharm.2017.01.024
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Issue Pt 2
Keywords Glucans extraction
Spent yeast
Skin safety
Language English
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Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
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References Chipinda, Hettick, Siegel (bb0405) 2011; 2011
Zülli, Suter (bb0100) 1995; 11
Shokri, Asadi, Khosravi (bb0125) 2008; 22
Latgé (bb0030) 2007; 66
Kashem, Kaplan (bb0485) 2016; 37
Vetvicka, Vetvickova (bb0395) 2011; 11
Almeida, Sarmento, Rodrigues (bb0120) 2017; 519
Breil, Abert Vian, Zemb, Kunz, Chemat (bb0140) 2017; 18
Johnson, Stevenson, Prêle, Fear, Wood (bb0370) 2020; 8
Xin, Ji, Cho, Roh, You, Park, Jung (bb0390) 2022; 30
Aguilar-Uscanga, François (bb0005) 2003; 37
Bligh, Dyer (bb0135) 1959; 37
Khan, Gani, Masoodi, Amin, Wani, Khanday, Gani (bb0090) 2016; 140
Li, Bai, Peng, Yi, Luo, Yang, Liu, Wang, He, Wang, Zhu, Wang, Tao, Zheng, Su, Hu (bb0470) 2020; 11
Ding, Wang, Xiong, Zhao, Huang (bb0130) 2013; 48
Lei, Wang, Zhang, Xiao, Fei, Wang, Zhang, Zheng, Wang, Yang, Xue (bb0085) 2015; 16
Yuan, Lan, He, Li, Ma (bb0055) 2019; 25
Caseiro, Dias, de Andrade Fontes, Bule (bb0040) 2022; 23
Soltés, Alfoldi, Sandula (bb0305) 1993; 48
Chung, Kim, Quan, Jung, Gautam, Cho, Kim, Kang, Che, Lee, Jeong, Heo, Seok (bb0435) 2018; 299
Kalka, Daniel-Wójcik, Mrzyk, Adarowska, Kalka, Daniel-Wójcik, Mrzyk (bb0425) 2022; 10
Carvalho, Ana, Santos Pedrosa, Pintado, Pinto-Ribeiro, Madureira (bb0440) 2022
Kushnirov (bb0215) 2000; 16
Cerci, Yildirim, Ceyhan, Bozkurt, Doguc, Gokicimen (bb0385) 2008; 20
Vargas-Hernández, Ventura-Gallegos, Ventura-Ayala, Torres, Zentella, Pedraza-Sánchez (bb0415) 2020; 355
Fusté, Guasch, Guillen, Anerillas, Cemeli, Pedraza, Ferrezuelo, Encinas, Moralejo, Garí (bb0280) 2019; 210
Kagimura, Cunha, Barbosa, Dekker, Malfatti (bb0250) 2014; 72
Severn, Horswill (bb0460) 2023; 21
Quaresma (bb0105) 2019; 32
Bastos, Coelho, Coimbra (bb0145) 2015; 124
Sui, Kawakami, Sakurai, Hara, Nohmi (bb0160) 2009; 31
Robert, Cascella, Mellai, Barizzone, Mignone, Massa, Nobile, Bona (bb0480) 2022; 10
Parlet, Brown, Horswill (bb0490) 2019; 27
Seo, Hyun, Choi, Kim, Cho (bb0080) 2019; 62
Medeiros, Cordeiro, Cavalcanti, Melchuna, da Lima, Filho, Medeiros, Rocha, Oliveira, Faria, Sassaki, Rocha, Sales (bb0070) 2012; 13
Brown, Taylor, Reid, Willment, Williams, Martinez-Pomares, Wong, Gordon (bb0330) 2002; 196
Proctor, Dangana, Sexton, Fukuda, Yelin, Stanley, Bell, Baskaran, Deming, Chen, Conlan, Park, Mullikin, Thomas, Young, Bouffard, Barnabas, Brooks, Han, Ho, Kim, Legaspi, Maduro, Marfani, Montemayor, Riebow, Schandler, Schmidt, Sison, Stantripop, Black, Dekhtyar, Masiello, McDowell, Thomas, Vemulapalli, Welsh, Vallabhaneni, Chiller, Forsberg, Black, Pacilli, Kong, Lin, Schoeny, Litvintseva, Segre, Hayden (bb0465) 2021; 27
Kanjan, Sahasrabudhe, de Haan, de Vos (bb0340) 2017; 37
Duque, Descoteaux (bb0355) 2014; 5
Association of Official Analytical Chemists (bb0150) 2005
Lesage, Bussey (bb0020) 2006; 70
Amer, Saber, Markeb, Elkhawaga, Mekhemer, Zohri, Abujamel, Harakeh, Abd-Allah (bb0290) 2021; 26
Chung, Quan, Jung, Ravi, Cho, Kang, Kim, Che, Lee, Jeong, Heo, Seok (bb0420) 2018; 46
Cosseau, Romano-Bertrand, Duplan, Lucas, Ingrassia, Pigasse, Roques, Jumas-Bilak (bb0455) 2016; 2
Thammakiti, Suphantharika, Phaesuwan, Verduyn (bb0240) 2004; 39
Jung, Che, Lim, Chun, Heo, Seok (bb0430) 2016; 36
Young, Dong, Jacobs (bb0235) 2000; 275
Byrd, Belkaid, Segre (bb0445) 2018; 16
Barrientos, Clerigo, Paano (bb0265) 2016; 93
Lacy, Stow (bb0360) 2011; 118
Kapteyn, Van Den Ende, Klis (bb0010) 1999; 1426
Kogan, Staško, Bauerová, Polovka, Šoltés, Brezová, Navarová, Mihalová (bb0095) 2005; 61
Wu, Chen, Xin, Zhang, Ren, Lei, Chu, Wang, Tang (bb0380) 2016; 11
Standard (bb0155) 2009
Costa, Pereira, Ribeiro, Casanova, Freixo, Pintado, Ramos (bb0310) 2022; 12
Liu, Wu, Wu, Algharib, Gong, Hu, Luo, Zhou, Pan, Yan, Wang (bb0060) 2021; 173
Ma, Chen, Wu, Li, Wang, Li (bb0260) 2022
Zykova, Balandina, Vorokhobina, Kuznetsova, Engstad, Zykova (bb0075) 2014; 5
Šandula, Kogan, Kačuráková, MacHová (bb0285) 1999; 38
Lee, Jeong, Oh, Lee, Mun, Lee, Jo, Heo, Baek, Heo, Kang, Han (bb0475) 2021; 43
Noss, Doekes, Thorne, Heederik, Wouters (bb0335) 2013; 19
(bb0165) 2020
Bastos, Oliveira, Gaspar, Mano, Coimbra, Coelho (bb0025) 2022; 277
(bb0175) 2023
Avramia, Amariei (bb0050) 2021; 22
Pinto, Coelho, Nunes, Brandão, Coimbra (bb0225) 2015; 116
Theis, Santos, Appelt, Barbosa-Dekker, Vetvicka, Dekker, Cunha (bb0255) 2019; 20
Wang, Yao, Guan, Wu, Kennedy (bb0275) 2005; 59
Kaur, Sharma, Ji, Xu, Agyei (bb0245) 2020; 8
Limon, Skalski, Underhill (bb0450) 2017; 22
Liu, Wang, Cui, Liu (bb0210) 2008; 22
Abedini, Mohammadi, Dahmardehei, Ajami, Salimi, Khalandi, Mohsenzadegan, Seif, Shirvan, Yaalimadad, Roudbary, Rodrigues (bb0375) 2022; 8
Boutros, Magee, Cox (bb0035) 2022; 367
Bzducha-Wróbel, Kieliszek, Błażejak (bb0230) 2013; 237
(bb0170) 2014
Sahasrabudhe, Dokter-Fokkens, de Vos (bb0350) 2016; 60
Teparić, Lozančić, Mrša (bb0015) 2020; 21
Bergandi, Apprato, Silvagno (bb0345) 2021; 22
Liu, Chu, Kalantar-Zadeh, George, Young, Liu (bb0315) 2021; 8
Herre, Gordon, Brown (bb0325) 2004; 40
Magnani, Calliari, de Macedo, Mori, de Syllos Cólus, Castro-Gomez (bb0220) 2009; 78
Barthe, Bavoux, Finot, Mouche, Cuceu-Petrenci, Forreryd, Hansson, Johansson, Lemkine, Thénot, Osman-Ponchet (bb0115) 2021; 8
Freimund, Sauter, Käppeli, Dutler (bb0205) 2003; 54
Kagimura, Da Cunha, Theis, Malfatti, Dekker, Barbosa, Teixeira, Salomé (bb0270) 2015; 127
Ruiz-Herrera, Ortiz-Castellanos (bb0200) 2019; 5
(bb0180) 2023
Mishra, Tripathi, Yadav, Singh (bb0365) 2023; 234
Luz-Veiga, Amorim, Pinto-Ribeiro, Oliveira, Silva, Pimentel, Rodríguez-Alcalá, Madureira, Pintado, Azevedo-Silva, Fernandes (bb0190) 2023; 24
Chan, Chan, Sze (bb0320) 2009; 2
Zhang, Liu, Zhao, Wang, Song, Zhao (bb0410) 2022; 205
Carvalho, Pinto-Ribeiro, Castro, Pedrosa, Oliveira, Pintado, Madureira (bb0185) 2022
Naruemon, Romanee, Cheunjit, Xiao, McLandsborough, Pawadee (bb0300) 2013; 20
Bikmurzin, Bandzevičiūtė, Maršalka, Maneikis, Kalėdienė (bb0295) 2022; 27
Bzducha-Wróbel, Blłazejak, Kawarska, Stasiak-Rózańska, Gientka, Majewska (bb0195) 2014; 19
Machová, Čížová, Bystrický (bb0065) 2014; 112
Majtan, Jesenak (bb0110) 2018; 23
Zhu, Du, Xu (bb0045) 2016; 52
OECD Guidelines for the Testing of Chemicals (bb0400) 2014
Soltés (10.1016/j.ijbiomac.2024.130933_bb0305) 1993; 48
Barrientos (10.1016/j.ijbiomac.2024.130933_bb0265) 2016; 93
Vetvicka (10.1016/j.ijbiomac.2024.130933_bb0395) 2011; 11
(10.1016/j.ijbiomac.2024.130933_bb0170) 2014
Bzducha-Wróbel (10.1016/j.ijbiomac.2024.130933_bb0195) 2014; 19
Costa (10.1016/j.ijbiomac.2024.130933_bb0310) 2022; 12
Khan (10.1016/j.ijbiomac.2024.130933_bb0090) 2016; 140
Yuan (10.1016/j.ijbiomac.2024.130933_bb0055) 2019; 25
Abedini (10.1016/j.ijbiomac.2024.130933_bb0375) 2022; 8
Young (10.1016/j.ijbiomac.2024.130933_bb0235) 2000; 275
Cosseau (10.1016/j.ijbiomac.2024.130933_bb0455) 2016; 2
Johnson (10.1016/j.ijbiomac.2024.130933_bb0370) 2020; 8
Fusté (10.1016/j.ijbiomac.2024.130933_bb0280) 2019; 210
Šandula (10.1016/j.ijbiomac.2024.130933_bb0285) 1999; 38
Li (10.1016/j.ijbiomac.2024.130933_bb0470) 2020; 11
Breil (10.1016/j.ijbiomac.2024.130933_bb0140) 2017; 18
Zülli (10.1016/j.ijbiomac.2024.130933_bb0100) 1995; 11
Chipinda (10.1016/j.ijbiomac.2024.130933_bb0405) 2011; 2011
Duque (10.1016/j.ijbiomac.2024.130933_bb0355) 2014; 5
Seo (10.1016/j.ijbiomac.2024.130933_bb0080) 2019; 62
Thammakiti (10.1016/j.ijbiomac.2024.130933_bb0240) 2004; 39
Chan (10.1016/j.ijbiomac.2024.130933_bb0320) 2009; 2
Freimund (10.1016/j.ijbiomac.2024.130933_bb0205) 2003; 54
Shokri (10.1016/j.ijbiomac.2024.130933_bb0125) 2008; 22
(10.1016/j.ijbiomac.2024.130933_bb0165) 2020
Avramia (10.1016/j.ijbiomac.2024.130933_bb0050) 2021; 22
Limon (10.1016/j.ijbiomac.2024.130933_bb0450) 2017; 22
Parlet (10.1016/j.ijbiomac.2024.130933_bb0490) 2019; 27
Theis (10.1016/j.ijbiomac.2024.130933_bb0255) 2019; 20
Teparić (10.1016/j.ijbiomac.2024.130933_bb0015) 2020; 21
Zhu (10.1016/j.ijbiomac.2024.130933_bb0045) 2016; 52
Caseiro (10.1016/j.ijbiomac.2024.130933_bb0040) 2022; 23
Quaresma (10.1016/j.ijbiomac.2024.130933_bb0105) 2019; 32
Zhang (10.1016/j.ijbiomac.2024.130933_bb0410) 2022; 205
Magnani (10.1016/j.ijbiomac.2024.130933_bb0220) 2009; 78
Latgé (10.1016/j.ijbiomac.2024.130933_bb0030) 2007; 66
Sui (10.1016/j.ijbiomac.2024.130933_bb0160) 2009; 31
Ruiz-Herrera (10.1016/j.ijbiomac.2024.130933_bb0200) 2019; 5
Kogan (10.1016/j.ijbiomac.2024.130933_bb0095) 2005; 61
Ding (10.1016/j.ijbiomac.2024.130933_bb0130) 2013; 48
Carvalho (10.1016/j.ijbiomac.2024.130933_bb0185) 2022
Amer (10.1016/j.ijbiomac.2024.130933_bb0290) 2021; 26
Liu (10.1016/j.ijbiomac.2024.130933_bb0315) 2021; 8
Carvalho (10.1016/j.ijbiomac.2024.130933_bb0440) 2022
Cerci (10.1016/j.ijbiomac.2024.130933_bb0385) 2008; 20
Lei (10.1016/j.ijbiomac.2024.130933_bb0085) 2015; 16
Kaur (10.1016/j.ijbiomac.2024.130933_bb0245) 2020; 8
Kagimura (10.1016/j.ijbiomac.2024.130933_bb0270) 2015; 127
Mishra (10.1016/j.ijbiomac.2024.130933_bb0365) 2023; 234
Robert (10.1016/j.ijbiomac.2024.130933_bb0480) 2022; 10
Almeida (10.1016/j.ijbiomac.2024.130933_bb0120) 2017; 519
Chung (10.1016/j.ijbiomac.2024.130933_bb0435) 2018; 299
Bastos (10.1016/j.ijbiomac.2024.130933_bb0145) 2015; 124
Chung (10.1016/j.ijbiomac.2024.130933_bb0420) 2018; 46
Boutros (10.1016/j.ijbiomac.2024.130933_bb0035) 2022; 367
Zykova (10.1016/j.ijbiomac.2024.130933_bb0075) 2014; 5
Brown (10.1016/j.ijbiomac.2024.130933_bb0330) 2002; 196
Jung (10.1016/j.ijbiomac.2024.130933_bb0430) 2016; 36
Kushnirov (10.1016/j.ijbiomac.2024.130933_bb0215) 2000; 16
Bzducha-Wróbel (10.1016/j.ijbiomac.2024.130933_bb0230) 2013; 237
Wu (10.1016/j.ijbiomac.2024.130933_bb0380) 2016; 11
Wang (10.1016/j.ijbiomac.2024.130933_bb0275) 2005; 59
Byrd (10.1016/j.ijbiomac.2024.130933_bb0445) 2018; 16
Liu (10.1016/j.ijbiomac.2024.130933_bb0210) 2008; 22
Machová (10.1016/j.ijbiomac.2024.130933_bb0065) 2014; 112
Standard (10.1016/j.ijbiomac.2024.130933_bb0155) 2009
Lee (10.1016/j.ijbiomac.2024.130933_bb0475) 2021; 43
Sahasrabudhe (10.1016/j.ijbiomac.2024.130933_bb0350) 2016; 60
Aguilar-Uscanga (10.1016/j.ijbiomac.2024.130933_bb0005) 2003; 37
Majtan (10.1016/j.ijbiomac.2024.130933_bb0110) 2018; 23
Liu (10.1016/j.ijbiomac.2024.130933_bb0060) 2021; 173
Barthe (10.1016/j.ijbiomac.2024.130933_bb0115) 2021; 8
Kashem (10.1016/j.ijbiomac.2024.130933_bb0485) 2016; 37
Medeiros (10.1016/j.ijbiomac.2024.130933_bb0070) 2012; 13
Kanjan (10.1016/j.ijbiomac.2024.130933_bb0340) 2017; 37
Severn (10.1016/j.ijbiomac.2024.130933_bb0460) 2023; 21
Xin (10.1016/j.ijbiomac.2024.130933_bb0390) 2022; 30
Bastos (10.1016/j.ijbiomac.2024.130933_bb0025) 2022; 277
Kapteyn (10.1016/j.ijbiomac.2024.130933_bb0010) 1999; 1426
Association of Official Analytical Chemists (10.1016/j.ijbiomac.2024.130933_bb0150) 2005
Naruemon (10.1016/j.ijbiomac.2024.130933_bb0300) 2013; 20
Ma (10.1016/j.ijbiomac.2024.130933_bb0260) 2022
Noss (10.1016/j.ijbiomac.2024.130933_bb0335) 2013; 19
Luz-Veiga (10.1016/j.ijbiomac.2024.130933_bb0190) 2023; 24
OECD Guidelines for the Testing of Chemicals (10.1016/j.ijbiomac.2024.130933_bb0400) 2014
Herre (10.1016/j.ijbiomac.2024.130933_bb0325) 2004; 40
Lesage (10.1016/j.ijbiomac.2024.130933_bb0020) 2006; 70
Lacy (10.1016/j.ijbiomac.2024.130933_bb0360) 2011; 118
(10.1016/j.ijbiomac.2024.130933_bb0180) 2023
Vargas-Hernández (10.1016/j.ijbiomac.2024.130933_bb0415) 2020; 355
Pinto (10.1016/j.ijbiomac.2024.130933_bb0225) 2015; 116
Bergandi (10.1016/j.ijbiomac.2024.130933_bb0345) 2021; 22
Proctor (10.1016/j.ijbiomac.2024.130933_bb0465) 2021; 27
Kalka (10.1016/j.ijbiomac.2024.130933_bb0425) 2022; 10
(10.1016/j.ijbiomac.2024.130933_bb0175) 2023
Bikmurzin (10.1016/j.ijbiomac.2024.130933_bb0295) 2022; 27
Kagimura (10.1016/j.ijbiomac.2024.130933_bb0250) 2014; 72
Bligh (10.1016/j.ijbiomac.2024.130933_bb0135) 1959; 37
References_xml – volume: 22
  start-page: 414
  year: 2008
  end-page: 421
  ident: bb0125
  article-title: Isolation of b-glucan from the cell wall of Saccharomyces cerevisiae
  publication-title: Nat. Prod. Res.
– volume: 27
  start-page: 1401
  year: 2021
  end-page: 1409
  ident: bb0465
  article-title: Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility
  publication-title: Nat Med.
– volume: 72
  start-page: 588
  year: 2014
  end-page: 598
  ident: bb0250
  article-title: Biological activities of derivatized D-glucans: a review
  publication-title: Int. J. Biol. Macromol.
– volume: 196
  start-page: 407
  year: 2002
  end-page: 412
  ident: bb0330
  article-title: Dectin-1 is a major β-glucan receptor on macrophages
  publication-title: J. Exp. Med.
– volume: 11
  start-page: 2603
  year: 2020
  ident: bb0470
  article-title: New insights into the skin microbial communities and skin aging
  publication-title: Front. Microbiol.
– volume: 210
  start-page: 389
  year: 2019
  end-page: 398
  ident: bb0280
  article-title: Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
  publication-title: Carbohydr. Polym.
– volume: 8
  start-page: 50
  year: 2021
  ident: bb0115
  article-title: Safety testing of cosmetic products: overview of established methods and new approach methodologies (NAMs)
  publication-title: Cosmetics
– volume: 12
  year: 2022
  ident: bb0310
  article-title: Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics
  publication-title: Applied Sciences (Switzerland).
– volume: 173
  start-page: 445
  year: 2021
  end-page: 456
  ident: bb0060
  article-title: Structure, preparation, modification, and bioactivities of β-glucan and mannan from yeast cell wall: a review
  publication-title: Int. J. Biol. Macromol.
– volume: 22
  start-page: 239
  year: 2008
  end-page: 247
  ident: bb0210
  article-title: A new isolation method of β-d-glucans from spent yeast Saccharomyces cerevisiae
  publication-title: Food Hydrocoll.
– volume: 8
  year: 2020
  ident: bb0370
  article-title: The role of IL-6 in skin fibrosis and cutaneous wound healing
  publication-title: Biomedicines
– year: 2009
  ident: bb0155
  article-title: ISO 10993-5:2009 Biological Evaluation of Medical Devices. Part 5: Tests for In Vitro Cytotoxicity
– volume: 8
  start-page: 263
  year: 2022
  ident: bb0375
  article-title: Enhancing of wound healing in burn patients through Candida albicans β-glucan
  publication-title: Journal of Fungi.
– volume: 70
  start-page: 317
  year: 2006
  end-page: 343
  ident: bb0020
  article-title: Cell Wall assembly in Saccharomyces cerevisiae
  publication-title: Microbiol. Mol. Biol. Rev.
– volume: 54
  start-page: 159
  year: 2003
  end-page: 171
  ident: bb0205
  article-title: A new non-degrading isolation process for 1,3-β-D-glucan of high purity from baker’s yeast Saccharomyces cerevisiae
  publication-title: Carbohydr. Polym.
– volume: 13
  start-page: 8142
  year: 2012
  end-page: 8158
  ident: bb0070
  article-title: Effects of purified Saccharomyces cerevisiae (1→3)-β-glucan on venous ulcer healing
  publication-title: Int. J. Mol. Sci.
– volume: 5
  start-page: 392
  year: 2014
  end-page: 399
  ident: bb0075
  article-title: Macrophage stimulating agent yeast β-1,3/1,6-glucan as a topical treatment of diabetic foot and leg ulcers: a randomized, double blind, placebo-controlled phase II study
  publication-title: J Diabetes Investig.
– volume: 11
  year: 2016
  ident: bb0380
  article-title: Nanofibrous asymmetric membranes self-organized from chemically heterogeneous electrospun mats for skin tissue engineering
  publication-title: Biomedical Materials (Bristol).
– volume: 5
  start-page: 491
  year: 2014
  ident: bb0355
  article-title: Macrophage cytokines: involvement in immunity and infectious diseases
  publication-title: Front. Immunol.
– volume: 118
  start-page: 9
  year: 2011
  end-page: 18
  ident: bb0360
  article-title: Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
  publication-title: Blood
– volume: 66
  start-page: 279
  year: 2007
  end-page: 290
  ident: bb0030
  article-title: The cell wall: a carbohydrate Armour for the fungal cell
  publication-title: Mol. Microbiol.
– volume: 11
  start-page: 46
  year: 1995
  end-page: 50
  ident: bb0100
  article-title: Anti-aging and Photoprotecting effects of carboxymethylated glucan from baker’s yeast
  publication-title: Euro Cosmetics
– volume: 62
  start-page: 1
  year: 2019
  end-page: 9
  ident: bb0080
  article-title: The wound healing effect of four types of beta-glucan
  publication-title: Appl Biol. Chem.
– volume: 37
  start-page: 433
  year: 2017
  end-page: 440
  ident: bb0340
  article-title: Immune effects of β-glucan are determined by combined effects on Dectin-1, TLR2, 4 and 5
  publication-title: J. Funct. Foods
– volume: 22
  start-page: 4869
  year: 2021
  ident: bb0345
  article-title: Vitamin d and beta-glucans synergically stimulate human macrophage activity
  publication-title: Int. J. Mol. Sci.
– year: 2020
  ident: bb0165
  publication-title: OECD Guidelines for the Testing of Chemicals, Test No. 471: Bacterial Reverse Mutation Test
– volume: 26
  start-page: 2113
  year: 2021
  ident: bb0290
  article-title: Enhancement of β-glucan biological activity using a modified acid-base extraction method from saccharomyces cerevisiae
  publication-title: Molecules
– volume: 16
  start-page: 857
  year: 2000
  end-page: 860
  ident: bb0215
  article-title: Yeast functional analysis report rapid and reliable protein extraction from yeast
  publication-title: Yeast
– volume: 140
  start-page: 442
  year: 2016
  end-page: 450
  ident: bb0090
  article-title: Structural, thermal, functional, antioxidant & antimicrobial properties of β-d-glucan extracted from baker’s yeast (Saccharomyces cereviseae) - effect of γ-irradiation
  publication-title: Carbohydr. Polym.
– volume: 519
  start-page: 178
  year: 2017
  end-page: 185
  ident: bb0120
  article-title: Insights on
  publication-title: Int. J. Pharm.
– volume: 8
  start-page: 1
  year: 2020
  ident: bb0245
  article-title: Structural features, modification, and functionalities of beta-glucan
  publication-title: Fibers
– volume: 93
  start-page: 226
  year: 2016
  end-page: 234
  ident: bb0265
  article-title: Extraction, isolation and MALDI-QTOF MS/MS analysis of β-D-glucan from the fruiting bodies of Daedalea quercina
  publication-title: Int. J. Biol. Macromol.
– volume: 39
  start-page: 21
  year: 2004
  end-page: 29
  ident: bb0240
  article-title: Preparation of spent brewer’s yeast β-glucans for potential applications in the food industry
  publication-title: Int. J. Food Sci. Technol.
– volume: 36
  start-page: 1129
  year: 2016
  end-page: 1136
  ident: bb0430
  article-title: Discrimination of skin sensitizers from non-sensitizers by interleukin-1α and interleukin-6 production on cultured human keratinocytes
  publication-title: J. Appl. Toxicol.
– volume: 18
  year: 2017
  ident: bb0140
  article-title: “Bligh and Dyer” and Folch methods for solid–liquid–liquid extraction of lipids from microorganisms. Comprehension of solvatation mechanisms and towards substitution with alternative solvents
  publication-title: Int. J. Mol. Sci.
– volume: 20
  start-page: 341
  year: 2008
  end-page: 346
  ident: bb0385
  article-title: The effects of topical and systemic beta glucan administration on wound healing impaired by corticosteroids
  publication-title: Wounds
– volume: 20
  start-page: 1953
  year: 2013
  ident: bb0300
  article-title: Influence of additives on Saccharomyces cerevisiae [Beta]-glucan production
  publication-title: Int. Food Res. J.
– volume: 205
  start-page: 430
  year: 2022
  end-page: 441
  ident: bb0410
  article-title: The phagocytic receptors of β-glucan
  publication-title: Int. J. Biol. Macromol.
– volume: 46
  start-page: 304
  year: 2018
  end-page: 312
  ident: bb0420
  article-title: Intra- and inter-laboratory reproducibility and predictivity of the HaCaSens assay: a skin sensitization test using human keratinocytes, HaCaT
  publication-title: Toxicol. In Vitro
– volume: 22
  start-page: 1
  year: 2021
  end-page: 26
  ident: bb0050
  article-title: Spent Brewer’s yeast as a source of insoluble β-glucans
  publication-title: Int. J. Mol. Sci.
– year: 2022
  ident: bb0260
  article-title: The structure and in vitro antioxidant activity of carboxymethyl glucans
  publication-title: Nat. Prod. Res.
– volume: 23
  year: 2018
  ident: bb0110
  article-title: β-Glucans: multi-functional modulator of wound healing
  publication-title: Molecules
– volume: 127
  start-page: 390
  year: 2015
  end-page: 399
  ident: bb0270
  article-title: Carboxymethylation of (1 → 6)-β-glucan (lasiodiplodan): preparation, characterization and antioxidant evaluation
  publication-title: Carbohydr. Polym.
– volume: 19
  start-page: 10
  year: 2013
  end-page: 19
  ident: bb0335
  article-title: Comparison of the potency of a variety of β-glucans to induce cytokine production in human whole blood
  publication-title: Innate Immun.
– volume: 22
  start-page: 156
  year: 2017
  end-page: 165
  ident: bb0450
  article-title: Commensal Fungi in health and disease
  publication-title: Cell Host Microbe
– volume: 59
  start-page: 93
  year: 2005
  end-page: 99
  ident: bb0275
  article-title: A novel process for preparation of (1 → 3)-β-D-glucan sulphate by a heterogeneous reaction and its structural elucidation
  publication-title: Carbohydr. Polym.
– volume: 78
  start-page: 658
  year: 2009
  end-page: 665
  ident: bb0220
  article-title: Optimized methodology for extraction of (1 → 3)(1 → 6)-β-d-glucan from
  publication-title: Carbohydr. Polym.
– volume: 367
  year: 2022
  ident: bb0035
  article-title: Comparison of structural differences between yeast β-glucan sourced from different strains of saccharomyces cerevisiae and processed using proprietary manufacturing processes
  publication-title: Food Chem.
– volume: 37
  start-page: 911
  year: 1959
  end-page: 917
  ident: bb0135
  article-title: A rapid method of total lipid extraction and purification
  publication-title: Can. J. Biochem. Physiol.
– volume: 27
  start-page: 497
  year: 2019
  end-page: 507
  ident: bb0490
  article-title: Commensal staphylococci influence Staphylococcus aureus skin colonization and disease
  publication-title: Trends Microbiol.
– volume: 2011
  start-page: 1
  year: 2011
  end-page: 11
  ident: bb0405
  article-title: Haptenation: chemical reactivity and protein binding
  publication-title: J Allergy (Cairo).
– year: 2005
  ident: bb0150
  article-title: Official Methods of Analysis
– volume: 60
  start-page: 2514
  year: 2016
  end-page: 2522
  ident: bb0350
  article-title: Particulate β-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells
  publication-title: Mol. Nutr. Food Res.
– volume: 237
  start-page: 489
  year: 2013
  end-page: 499
  ident: bb0230
  article-title: Chemical composition of the cell wall of probiotic and brewer’s yeast in response to cultivation medium with glycerol as a carbon source
  publication-title: Eur. Food Res. Technol.
– volume: 16
  start-page: 143
  year: 2018
  end-page: 155
  ident: bb0445
  article-title: The human skin microbiome
  publication-title: Nat. Rev. Microbiol.
– year: 2014
  ident: bb0400
  article-title: The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
– volume: 43
  start-page: 1483
  year: 2021
  end-page: 1495
  ident: bb0475
  article-title: Comparative analysis of human facial skin microbiome between topical sites compared to entire face
  publication-title: Genes Genomics
– volume: 48
  start-page: 253
  year: 2013
  end-page: 259
  ident: bb0130
  article-title: Optimised methodology for carboxymethylation of (1→3)-β-d-glucan from yeast (Saccharomyces cerevisiae) and promotion of mechanical activation
  publication-title: Int. J. Food Sci. Technol.
– volume: 19
  start-page: 20941
  year: 2014
  end-page: 20961
  ident: bb0195
  article-title: Evaluation of the efficiency of different disruption methods on yeast cell wall preparation for β-glucan isolation
  publication-title: Molecules
– volume: 5
  year: 2019
  ident: bb0200
  article-title: Cell wall glucans of fungi. A review
  publication-title: Cell Surface
– volume: 275
  start-page: 11874
  year: 2000
  end-page: 11879
  ident: bb0235
  article-title: Observation of a partially opened triple-helix conformation in 1→3-β- glucan by fluorescence resonance energy transfer spectroscopy
  publication-title: J. Biol. Chem.
– volume: 8
  year: 2021
  ident: bb0315
  article-title: Cytokines: from clinical significance to quantification
  publication-title: Adv. Sci.
– volume: 10
  start-page: 740
  year: 2022
  ident: bb0425
  article-title: Alternative methods for skin-sensitization assessment
  publication-title: Toxics
– volume: 2
  start-page: 25
  year: 2009
  ident: bb0320
  article-title: The effects of beta-glucan on human immune and cancer cells
  publication-title: J. Hematol. Oncol.
– volume: 234
  year: 2023
  ident: bb0365
  article-title: Beta glucan as an immune stimulant in tumor microenvironment — insight into lessons and promises from past decade
  publication-title: Int. J. Biol. Macromol.
– volume: 52
  start-page: 275
  year: 2016
  end-page: 288
  ident: bb0045
  article-title: A critical review on production and industrial applications of beta-glucans
  publication-title: Food Hydrocoll.
– volume: 124
  start-page: 322
  year: 2015
  end-page: 330
  ident: bb0145
  article-title: Modifications of Saccharomyces pastorianus cell wall polysaccharides with brewing process
  publication-title: Carbohydr. Polym.
– volume: 1426
  start-page: 373
  year: 1999
  end-page: 383
  ident: bb0010
  article-title: The contribution of cell wall proteins to the organization of the yeast cell wall
  publication-title: Biochim. Biophys. Acta Gen. Subj.
– year: 2014
  ident: bb0170
  publication-title: OECD Guidelines for the Testing of Chemicals, Test No. 487: In Vitro Mammalian Cell Micronucleus Test
– volume: 27
  year: 2022
  ident: bb0295
  article-title: FT-IR method limitations for β-glucan analysis
  publication-title: Molecules
– volume: 32
  year: 2019
  ident: bb0105
  article-title: Organization of the skin immune system and compartmentalized immune responses in infectious diseases
  publication-title: Clin. Microbiol. Rev.
– volume: 24
  start-page: 2389
  year: 2023
  ident: bb0190
  article-title: Cannabidiol and Cannabigerol exert antimicrobial activity without compromising skin Microbiota
  publication-title: Int. J. Mol. Sci.
– volume: 40
  start-page: 869
  year: 2004
  end-page: 876
  ident: bb0325
  article-title: Dectin-1 and its role in the recognition of β-glucans by macrophages
  publication-title: Mol. Immunol.
– year: 2023
  ident: bb0180
  publication-title: OECD Guidelines for the Testing of Chemicals, Test No. 442E: In Vitro Skin Sensitisation
– volume: 20
  start-page: 2337
  year: 2019
  ident: bb0255
  article-title: Fungal exocellular (1-6)-β-D-glucan: carboxymethylation, characterization, and antioxidant activity
  publication-title: Int. J. Mol. Sci.
– volume: 10
  year: 2022
  ident: bb0480
  article-title: Influence of sex on the Microbiota of the human face
  publication-title: Microorganisms
– volume: 48
  start-page: 1313
  year: 1993
  end-page: 1319
  ident: bb0305
  article-title: HPLC and 13C-NMR study of carboxymethyl-β-(1 → 6)-D-gluco-β-(1 → 3)-D-glucan derived from saccharomyces cerevisiae
  publication-title: J. Appl. Polym. Sci.
– volume: 37
  start-page: 440
  year: 2016
  end-page: 450
  ident: bb0485
  article-title: Skin immunity to Candida albicans
  publication-title: Trends Immunol.
– volume: 112
  start-page: 603
  year: 2014
  end-page: 607
  ident: bb0065
  article-title: Effect of carboxymethylation on antioxidant properties and radical degradation of mannans and glucans
  publication-title: Carbohydr. Polym.
– volume: 11
  start-page: 169
  year: 2011
  end-page: 175
  ident: bb0395
  article-title: β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation
  publication-title: Orient Pharm Exp Med
– start-page: 14
  year: 2022
  end-page: 16
  ident: bb0185
  article-title: Preclinical model to evaluate how beneficial are cosmetic ingredients for skin microbiota
  publication-title: Proceedings of the 9th Beneficial Microbes Conference, Amsterdam, The Netherlands
– volume: 21
  start-page: 1
  year: 2020
  end-page: 17
  ident: bb0015
  article-title: Evolutionary overview of molecular interactions and enzymatic activities in the yeast cell walls
  publication-title: Int. J. Mol. Sci.
– volume: 30
  year: 2022
  ident: bb0390
  article-title: Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan
  publication-title: Biochem Biophys Rep.
– volume: 25
  year: 2019
  ident: bb0055
  article-title: Effect of the modifications on the physicochemical and biological properties of β-glucan-a critical review
  publication-title: Molecules
– volume: 2
  start-page: 33
  year: 2016
  end-page: 41
  ident: bb0455
  article-title: Proteobacteria from the human skin microbiota: species-level diversity and hypotheses
  publication-title: One Health.
– volume: 38
  start-page: 247
  year: 1999
  end-page: 253
  ident: bb0285
  article-title: Microbial (1→3)-β-D-glucans, their preparation, physico-chemical characterization and immunomodulatory activity
  publication-title: Carbohydr. Polym.
– volume: 61
  start-page: 18
  year: 2005
  end-page: 28
  ident: bb0095
  article-title: Antioxidant properties of yeast (1→3)-β-D-glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis
  publication-title: Carbohydr. Polym.
– volume: 277
  year: 2022
  ident: bb0025
  article-title: Brewer’s yeast polysaccharides — a review of their exquisite structural features and biomedical applications
  publication-title: Carbohydr. Polym.
– volume: 299
  start-page: 86
  year: 2018
  end-page: 94
  ident: bb0435
  article-title: Optimizing the cutoff for the identification of skin sensitizers by the HaCaSens assay: introducing an ROC-analysis-based cutoff approach
  publication-title: Toxicol. Lett.
– volume: 37
  start-page: 268
  year: 2003
  end-page: 274
  ident: bb0005
  article-title: A study of the yeast cell wall composition and structure in response to growth conditions and mode of cultivation
  publication-title: Lett. Appl. Microbiol.
– year: 2022
  ident: bb0440
  article-title: Skin microbiota and the cosmetic industry
  publication-title: Microb. Ecol.
– volume: 31
  start-page: 47
  year: 2009
  end-page: 55
  ident: bb0160
  article-title: Improvement and evaluation of high throughput fluctuation Ames test using 384-well plate with salmonella typhimurium TA100 and TA98
  publication-title: Genes and Environment.
– year: 2023
  ident: bb0175
  publication-title: OECD Guidelines for the Testing of Chemicals, Test No. 442C: In Chemico Skin Sensitisation
– volume: 16
  start-page: 21575
  year: 2015
  end-page: 21590
  ident: bb0085
  article-title: Effects of low molecular weight yeast β-glucan on antioxidant and immunological activities in mice
  publication-title: Int. J. Mol. Sci.
– volume: 116
  start-page: 215
  year: 2015
  end-page: 222
  ident: bb0225
  article-title: Valuation of brewers spent yeast polysaccharides: a structural characterization approach
  publication-title: Carbohydr. Polym.
– volume: 23
  start-page: 3156
  year: 2022
  ident: bb0040
  article-title: From Cancer therapy to winemaking: the molecular structure and applications of β-glucans and β-1, 3-Glucanases
  publication-title: Int. J. Mol. Sci.
– volume: 21
  start-page: 97
  year: 2023
  end-page: 111
  ident: bb0460
  article-title: Staphylococcus epidermidis and its dual lifestyle in skin health and infection
  publication-title: Nat. Rev. Microbiol.
– volume: 355
  year: 2020
  ident: bb0415
  article-title: THP-1 cells increase TNF-α production upon LPS + soluble human IgG co-stimulation supporting evidence for TLR4 and Fcγ receptors crosstalk
  publication-title: Cell. Immunol.
– volume: 275
  start-page: 11874
  year: 2000
  ident: 10.1016/j.ijbiomac.2024.130933_bb0235
  article-title: Observation of a partially opened triple-helix conformation in 1→3-β- glucan by fluorescence resonance energy transfer spectroscopy
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.275.16.11874
– volume: 2011
  start-page: 1
  year: 2011
  ident: 10.1016/j.ijbiomac.2024.130933_bb0405
  article-title: Haptenation: chemical reactivity and protein binding
  publication-title: J Allergy (Cairo).
  doi: 10.1155/2011/839682
– volume: 25
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0055
  article-title: Effect of the modifications on the physicochemical and biological properties of β-glucan-a critical review
  publication-title: Molecules
  doi: 10.3390/molecules25010057
– volume: 8
  start-page: 1
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0245
  article-title: Structural features, modification, and functionalities of beta-glucan
  publication-title: Fibers
  doi: 10.3390/fib8010001
– year: 2023
  ident: 10.1016/j.ijbiomac.2024.130933_bb0175
– volume: 1426
  start-page: 373
  year: 1999
  ident: 10.1016/j.ijbiomac.2024.130933_bb0010
  article-title: The contribution of cell wall proteins to the organization of the yeast cell wall
  publication-title: Biochim. Biophys. Acta Gen. Subj.
  doi: 10.1016/S0304-4165(98)00137-8
– volume: 8
  start-page: 263
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0375
  article-title: Enhancing of wound healing in burn patients through Candida albicans β-glucan
  publication-title: Journal of Fungi.
  doi: 10.3390/jof8030263
– volume: 16
  start-page: 143
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130933_bb0445
  article-title: The human skin microbiome
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.157
– volume: 2
  start-page: 33
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0455
  article-title: Proteobacteria from the human skin microbiota: species-level diversity and hypotheses
  publication-title: One Health.
  doi: 10.1016/j.onehlt.2016.02.002
– volume: 11
  start-page: 2603
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0470
  article-title: New insights into the skin microbial communities and skin aging
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2020.565549
– volume: 40
  start-page: 869
  year: 2004
  ident: 10.1016/j.ijbiomac.2024.130933_bb0325
  article-title: Dectin-1 and its role in the recognition of β-glucans by macrophages
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2003.10.007
– volume: 27
  start-page: 1401
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0465
  article-title: Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility
  publication-title: Nat Med.
  doi: 10.1038/s41591-021-01383-w
– volume: 11
  start-page: 46
  year: 1995
  ident: 10.1016/j.ijbiomac.2024.130933_bb0100
  article-title: Anti-aging and Photoprotecting effects of carboxymethylated glucan from baker’s yeast
  publication-title: Euro Cosmetics
– volume: 367
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0035
  article-title: Comparison of structural differences between yeast β-glucan sourced from different strains of saccharomyces cerevisiae and processed using proprietary manufacturing processes
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2021.130708
– volume: 355
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0415
  article-title: THP-1 cells increase TNF-α production upon LPS + soluble human IgG co-stimulation supporting evidence for TLR4 and Fcγ receptors crosstalk
  publication-title: Cell. Immunol.
  doi: 10.1016/j.cellimm.2020.104146
– volume: 72
  start-page: 588
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0250
  article-title: Biological activities of derivatized D-glucans: a review
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2014.09.008
– volume: 37
  start-page: 440
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0485
  article-title: Skin immunity to Candida albicans
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2016.04.007
– volume: 21
  start-page: 1
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0015
  article-title: Evolutionary overview of molecular interactions and enzymatic activities in the yeast cell walls
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21238996
– year: 2005
  ident: 10.1016/j.ijbiomac.2024.130933_bb0150
– volume: 46
  start-page: 304
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130933_bb0420
  article-title: Intra- and inter-laboratory reproducibility and predictivity of the HaCaSens assay: a skin sensitization test using human keratinocytes, HaCaT
  publication-title: Toxicol. In Vitro
  doi: 10.1016/j.tiv.2017.10.018
– volume: 210
  start-page: 389
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0280
  article-title: Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2019.01.090
– volume: 20
  start-page: 1953
  year: 2013
  ident: 10.1016/j.ijbiomac.2024.130933_bb0300
  article-title: Influence of additives on Saccharomyces cerevisiae [Beta]-glucan production
  publication-title: Int. Food Res. J.
– volume: 20
  start-page: 2337
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0255
  article-title: Fungal exocellular (1-6)-β-D-glucan: carboxymethylation, characterization, and antioxidant activity
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms20092337
– volume: 32
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0105
  article-title: Organization of the skin immune system and compartmentalized immune responses in infectious diseases
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00034-18
– volume: 299
  start-page: 86
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130933_bb0435
  article-title: Optimizing the cutoff for the identification of skin sensitizers by the HaCaSens assay: introducing an ROC-analysis-based cutoff approach
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2018.09.004
– volume: 112
  start-page: 603
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0065
  article-title: Effect of carboxymethylation on antioxidant properties and radical degradation of mannans and glucans
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2014.06.050
– volume: 22
  start-page: 1
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0050
  article-title: Spent Brewer’s yeast as a source of insoluble β-glucans
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22020825
– volume: 13
  start-page: 8142
  year: 2012
  ident: 10.1016/j.ijbiomac.2024.130933_bb0070
  article-title: Effects of purified Saccharomyces cerevisiae (1→3)-β-glucan on venous ulcer healing
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms13078142
– year: 2009
  ident: 10.1016/j.ijbiomac.2024.130933_bb0155
– volume: 205
  start-page: 430
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0410
  article-title: The phagocytic receptors of β-glucan
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2022.02.111
– volume: 27
  start-page: 497
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0490
  article-title: Commensal staphylococci influence Staphylococcus aureus skin colonization and disease
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2019.01.008
– volume: 8
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0315
  article-title: Cytokines: from clinical significance to quantification
  publication-title: Adv. Sci.
– volume: 5
  start-page: 491
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0355
  article-title: Macrophage cytokines: involvement in immunity and infectious diseases
  publication-title: Front. Immunol.
– volume: 196
  start-page: 407
  year: 2002
  ident: 10.1016/j.ijbiomac.2024.130933_bb0330
  article-title: Dectin-1 is a major β-glucan receptor on macrophages
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20020470
– volume: 52
  start-page: 275
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0045
  article-title: A critical review on production and industrial applications of beta-glucans
  publication-title: Food Hydrocoll.
  doi: 10.1016/j.foodhyd.2015.07.003
– year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0400
– volume: 277
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0025
  article-title: Brewer’s yeast polysaccharides — a review of their exquisite structural features and biomedical applications
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2021.118826
– volume: 54
  start-page: 159
  year: 2003
  ident: 10.1016/j.ijbiomac.2024.130933_bb0205
  article-title: A new non-degrading isolation process for 1,3-β-D-glucan of high purity from baker’s yeast Saccharomyces cerevisiae
  publication-title: Carbohydr. Polym.
  doi: 10.1016/S0144-8617(03)00162-0
– volume: 12
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0310
  article-title: Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics
  publication-title: Applied Sciences (Switzerland).
– volume: 22
  start-page: 4869
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0345
  article-title: Vitamin d and beta-glucans synergically stimulate human macrophage activity
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22094869
– volume: 30
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0390
  article-title: Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan
  publication-title: Biochem Biophys Rep.
– volume: 70
  start-page: 317
  year: 2006
  ident: 10.1016/j.ijbiomac.2024.130933_bb0020
  article-title: Cell Wall assembly in Saccharomyces cerevisiae
  publication-title: Microbiol. Mol. Biol. Rev.
  doi: 10.1128/MMBR.00038-05
– volume: 61
  start-page: 18
  year: 2005
  ident: 10.1016/j.ijbiomac.2024.130933_bb0095
  article-title: Antioxidant properties of yeast (1→3)-β-D-glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2005.02.010
– volume: 22
  start-page: 239
  year: 2008
  ident: 10.1016/j.ijbiomac.2024.130933_bb0210
  article-title: A new isolation method of β-d-glucans from spent yeast Saccharomyces cerevisiae
  publication-title: Food Hydrocoll.
  doi: 10.1016/j.foodhyd.2006.11.008
– volume: 16
  start-page: 21575
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130933_bb0085
  article-title: Effects of low molecular weight yeast β-glucan on antioxidant and immunological activities in mice
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms160921575
– volume: 140
  start-page: 442
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0090
  article-title: Structural, thermal, functional, antioxidant & antimicrobial properties of β-d-glucan extracted from baker’s yeast (Saccharomyces cereviseae) - effect of γ-irradiation
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2016.01.003
– volume: 37
  start-page: 433
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130933_bb0340
  article-title: Immune effects of β-glucan are determined by combined effects on Dectin-1, TLR2, 4 and 5
  publication-title: J. Funct. Foods
  doi: 10.1016/j.jff.2017.07.061
– volume: 43
  start-page: 1483
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0475
  article-title: Comparative analysis of human facial skin microbiome between topical sites compared to entire face
  publication-title: Genes Genomics
  doi: 10.1007/s13258-021-01180-2
– volume: 26
  start-page: 2113
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0290
  article-title: Enhancement of β-glucan biological activity using a modified acid-base extraction method from saccharomyces cerevisiae
  publication-title: Molecules
  doi: 10.3390/molecules26082113
– volume: 37
  start-page: 268
  year: 2003
  ident: 10.1016/j.ijbiomac.2024.130933_bb0005
  article-title: A study of the yeast cell wall composition and structure in response to growth conditions and mode of cultivation
  publication-title: Lett. Appl. Microbiol.
  doi: 10.1046/j.1472-765X.2003.01394.x
– volume: 31
  start-page: 47
  year: 2009
  ident: 10.1016/j.ijbiomac.2024.130933_bb0160
  article-title: Improvement and evaluation of high throughput fluctuation Ames test using 384-well plate with salmonella typhimurium TA100 and TA98
  publication-title: Genes and Environment.
  doi: 10.3123/jemsge.31.47
– volume: 118
  start-page: 9
  year: 2011
  ident: 10.1016/j.ijbiomac.2024.130933_bb0360
  article-title: Cytokine release from innate immune cells: association with diverse membrane trafficking pathways
  publication-title: Blood
  doi: 10.1182/blood-2010-08-265892
– volume: 27
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0295
  article-title: FT-IR method limitations for β-glucan analysis
  publication-title: Molecules
  doi: 10.3390/molecules27144616
– volume: 8
  year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0370
  article-title: The role of IL-6 in skin fibrosis and cutaneous wound healing
  publication-title: Biomedicines
  doi: 10.3390/biomedicines8050101
– volume: 60
  start-page: 2514
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0350
  article-title: Particulate β-glucans synergistically activate TLR4 and Dectin-1 in human dendritic cells
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201600356
– volume: 23
  start-page: 3156
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0040
  article-title: From Cancer therapy to winemaking: the molecular structure and applications of β-glucans and β-1, 3-Glucanases
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23063156
– volume: 173
  start-page: 445
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0060
  article-title: Structure, preparation, modification, and bioactivities of β-glucan and mannan from yeast cell wall: a review
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2021.01.125
– volume: 116
  start-page: 215
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130933_bb0225
  article-title: Valuation of brewers spent yeast polysaccharides: a structural characterization approach
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2014.03.010
– volume: 93
  start-page: 226
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0265
  article-title: Extraction, isolation and MALDI-QTOF MS/MS analysis of β-D-glucan from the fruiting bodies of Daedalea quercina
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2016.08.044
– volume: 16
  start-page: 857
  year: 2000
  ident: 10.1016/j.ijbiomac.2024.130933_bb0215
  article-title: Yeast functional analysis report rapid and reliable protein extraction from yeast
  publication-title: Yeast
  doi: 10.1002/1097-0061(20000630)16:9<857::AID-YEA561>3.0.CO;2-B
– volume: 39
  start-page: 21
  year: 2004
  ident: 10.1016/j.ijbiomac.2024.130933_bb0240
  article-title: Preparation of spent brewer’s yeast β-glucans for potential applications in the food industry
  publication-title: Int. J. Food Sci. Technol.
  doi: 10.1111/j.1365-2621.2004.00742.x
– year: 2020
  ident: 10.1016/j.ijbiomac.2024.130933_bb0165
– volume: 21
  start-page: 97
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130933_bb0460
  article-title: Staphylococcus epidermidis and its dual lifestyle in skin health and infection
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-022-00780-3
– volume: 36
  start-page: 1129
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0430
  article-title: Discrimination of skin sensitizers from non-sensitizers by interleukin-1α and interleukin-6 production on cultured human keratinocytes
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.3274
– volume: 59
  start-page: 93
  year: 2005
  ident: 10.1016/j.ijbiomac.2024.130933_bb0275
  article-title: A novel process for preparation of (1 → 3)-β-D-glucan sulphate by a heterogeneous reaction and its structural elucidation
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2004.09.003
– volume: 48
  start-page: 1313
  year: 1993
  ident: 10.1016/j.ijbiomac.2024.130933_bb0305
  article-title: HPLC and 13C-NMR study of carboxymethyl-β-(1 → 6)-D-gluco-β-(1 → 3)-D-glucan derived from saccharomyces cerevisiae
  publication-title: J. Appl. Polym. Sci.
  doi: 10.1002/app.1993.070480801
– volume: 24
  start-page: 2389
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130933_bb0190
  article-title: Cannabidiol and Cannabigerol exert antimicrobial activity without compromising skin Microbiota
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms24032389
– volume: 2
  start-page: 25
  year: 2009
  ident: 10.1016/j.ijbiomac.2024.130933_bb0320
  article-title: The effects of beta-glucan on human immune and cancer cells
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/1756-8722-2-25
– year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0260
  article-title: The structure and in vitro antioxidant activity of carboxymethyl glucans
  publication-title: Nat. Prod. Res.
– volume: 22
  start-page: 414
  year: 2008
  ident: 10.1016/j.ijbiomac.2024.130933_bb0125
  article-title: Isolation of b-glucan from the cell wall of Saccharomyces cerevisiae
  publication-title: Nat. Prod. Res.
  doi: 10.1080/14786410701591622
– volume: 11
  year: 2016
  ident: 10.1016/j.ijbiomac.2024.130933_bb0380
  article-title: Nanofibrous asymmetric membranes self-organized from chemically heterogeneous electrospun mats for skin tissue engineering
  publication-title: Biomedical Materials (Bristol).
– volume: 234
  year: 2023
  ident: 10.1016/j.ijbiomac.2024.130933_bb0365
  article-title: Beta glucan as an immune stimulant in tumor microenvironment — insight into lessons and promises from past decade
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2023.123617
– volume: 124
  start-page: 322
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130933_bb0145
  article-title: Modifications of Saccharomyces pastorianus cell wall polysaccharides with brewing process
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2015.02.031
– volume: 10
  start-page: 740
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0425
  article-title: Alternative methods for skin-sensitization assessment
  publication-title: Toxics
  doi: 10.3390/toxics10120740
– volume: 62
  start-page: 1
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0080
  article-title: The wound healing effect of four types of beta-glucan
  publication-title: Appl Biol. Chem.
  doi: 10.1186/s13765-019-0428-2
– volume: 37
  start-page: 911
  year: 1959
  ident: 10.1016/j.ijbiomac.2024.130933_bb0135
  article-title: A rapid method of total lipid extraction and purification
  publication-title: Can. J. Biochem. Physiol.
  doi: 10.1139/y59-099
– volume: 5
  start-page: 392
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0075
  article-title: Macrophage stimulating agent yeast β-1,3/1,6-glucan as a topical treatment of diabetic foot and leg ulcers: a randomized, double blind, placebo-controlled phase II study
  publication-title: J Diabetes Investig.
  doi: 10.1111/jdi.12165
– volume: 78
  start-page: 658
  year: 2009
  ident: 10.1016/j.ijbiomac.2024.130933_bb0220
  article-title: Optimized methodology for extraction of (1 → 3)(1 → 6)-β-d-glucan from Saccharomyces cerevisiae and in vitro evaluation of the cytotoxicity and genotoxicity of the corresponding carboxymethyl derivative
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2009.05.023
– volume: 19
  start-page: 10
  year: 2013
  ident: 10.1016/j.ijbiomac.2024.130933_bb0335
  article-title: Comparison of the potency of a variety of β-glucans to induce cytokine production in human whole blood
  publication-title: Innate Immun.
  doi: 10.1177/1753425912447129
– volume: 22
  start-page: 156
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130933_bb0450
  article-title: Commensal Fungi in health and disease
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.07.002
– volume: 127
  start-page: 390
  year: 2015
  ident: 10.1016/j.ijbiomac.2024.130933_bb0270
  article-title: Carboxymethylation of (1 → 6)-β-glucan (lasiodiplodan): preparation, characterization and antioxidant evaluation
  publication-title: Carbohydr. Polym.
  doi: 10.1016/j.carbpol.2015.03.045
– volume: 11
  start-page: 169
  year: 2011
  ident: 10.1016/j.ijbiomac.2024.130933_bb0395
  article-title: β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation
  publication-title: Orient Pharm Exp Med
  doi: 10.1007/s13596-011-0024-4
– volume: 48
  start-page: 253
  year: 2013
  ident: 10.1016/j.ijbiomac.2024.130933_bb0130
  article-title: Optimised methodology for carboxymethylation of (1→3)-β-d-glucan from yeast (Saccharomyces cerevisiae) and promotion of mechanical activation
  publication-title: Int. J. Food Sci. Technol.
  doi: 10.1111/j.1365-2621.2012.03181.x
– volume: 8
  start-page: 50
  year: 2021
  ident: 10.1016/j.ijbiomac.2024.130933_bb0115
  article-title: Safety testing of cosmetic products: overview of established methods and new approach methodologies (NAMs)
  publication-title: Cosmetics
  doi: 10.3390/cosmetics8020050
– year: 2023
  ident: 10.1016/j.ijbiomac.2024.130933_bb0180
– volume: 38
  start-page: 247
  year: 1999
  ident: 10.1016/j.ijbiomac.2024.130933_bb0285
  article-title: Microbial (1→3)-β-D-glucans, their preparation, physico-chemical characterization and immunomodulatory activity
  publication-title: Carbohydr. Polym.
  doi: 10.1016/S0144-8617(98)00099-X
– volume: 19
  start-page: 20941
  year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0195
  article-title: Evaluation of the efficiency of different disruption methods on yeast cell wall preparation for β-glucan isolation
  publication-title: Molecules
  doi: 10.3390/molecules191220941
– volume: 10
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0480
  article-title: Influence of sex on the Microbiota of the human face
  publication-title: Microorganisms
  doi: 10.3390/microorganisms10122470
– start-page: 14
  year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0185
  article-title: Preclinical model to evaluate how beneficial are cosmetic ingredients for skin microbiota
– volume: 18
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130933_bb0140
  article-title: “Bligh and Dyer” and Folch methods for solid–liquid–liquid extraction of lipids from microorganisms. Comprehension of solvatation mechanisms and towards substitution with alternative solvents
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms18040708
– volume: 237
  start-page: 489
  year: 2013
  ident: 10.1016/j.ijbiomac.2024.130933_bb0230
  article-title: Chemical composition of the cell wall of probiotic and brewer’s yeast in response to cultivation medium with glycerol as a carbon source
  publication-title: Eur. Food Res. Technol.
  doi: 10.1007/s00217-013-2016-8
– volume: 66
  start-page: 279
  year: 2007
  ident: 10.1016/j.ijbiomac.2024.130933_bb0030
  article-title: The cell wall: a carbohydrate Armour for the fungal cell
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.2007.05872.x
– volume: 20
  start-page: 341
  year: 2008
  ident: 10.1016/j.ijbiomac.2024.130933_bb0385
  article-title: The effects of topical and systemic beta glucan administration on wound healing impaired by corticosteroids
  publication-title: Wounds
– volume: 23
  year: 2018
  ident: 10.1016/j.ijbiomac.2024.130933_bb0110
  article-title: β-Glucans: multi-functional modulator of wound healing
  publication-title: Molecules
  doi: 10.3390/molecules23040806
– year: 2022
  ident: 10.1016/j.ijbiomac.2024.130933_bb0440
  article-title: Skin microbiota and the cosmetic industry
  publication-title: Microb. Ecol.
– year: 2014
  ident: 10.1016/j.ijbiomac.2024.130933_bb0170
– volume: 5
  year: 2019
  ident: 10.1016/j.ijbiomac.2024.130933_bb0200
  article-title: Cell wall glucans of fungi. A review
  publication-title: Cell Surface
  doi: 10.1016/j.tcsw.2019.100022
– volume: 519
  start-page: 178
  year: 2017
  ident: 10.1016/j.ijbiomac.2024.130933_bb0120
  article-title: Insights on in vitro models for safety and toxicity assessment of cosmetic ingredients
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.01.024
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Snippet Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have...
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SubjectTerms cell walls
circular economy
cytotoxicity
fermentation
genotoxicity
glucans
Glucans - chemistry
Glucans extraction
glucose
immunomodulators
ingredients
interleukin-6
interleukin-8
Polysaccharides - chemistry
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
safety assessment
Skin safety
Spent yeast
Water
water solubility
yeasts
Title Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application
URI https://dx.doi.org/10.1016/j.ijbiomac.2024.130933
https://www.ncbi.nlm.nih.gov/pubmed/38508554
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https://www.proquest.com/docview/3242079808
Volume 265
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