Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review

• Published in: International journal of molecular sciences Vol. 22; no. 9; p. 4526
• Main Authors: Aleksova, Aneta, Gagno, Giulia, Sinagra, Gianfranco, Beltrami, Antonio Paolo, Janjusevic, Milijana, Ippolito, Giuseppe, Zumla, Alimuddin, Fluca, Alessandra Lucia, Ferro, Federico
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.04.2021; MDPI
• Subjects: ADAM17 Protein - metabolism; Angiotensin-Converting Enzyme 2 - metabolism; Cardiovascular Diseases - complications; Cardiovascular Diseases - pathology; Coronaviruses; COVID-19 - complications; COVID-19 - pathology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - immunology; Hormones; Humans; Immune response; Receptors, Virus - metabolism; Review; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - physiology; Serine Endopeptidases - metabolism; Viral infections; COVID-19; ACE2; ADAM17; cardiovascular system; RAS; vaccines; TMPRSS2; pandemic; SARS- CoV-2

Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID-19) in humans. ACE-2 is a type I transmembrane metallocarboxypeptidase expressed in vascular endothelial cells, alveolar type 2...