SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19

• Published in: Autoimmunity (Chur, Switzerland) Vol. 56; no. 1; p. 2259133
• Main Authors: Franco, Alessandra, Song, Jaeyoon, Chambers, Christina, Sette, Alessandro, Grifoni, Alba
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.12.2023
• Subjects: COVID-19 - prevention & control; Humans; immune regulation; regulatory t cells (treg); SARS-CoV-2; t cell memory; T-Lymphocytes, Regulatory; Vaccination; vaccine; Vaccines; SARS-CoV-2; Immune regulation; Vaccine; Regulatory T cells (Treg); T cell memory

We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T ) and central m...