SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19
We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T ) and central m...
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| Published in | Autoimmunity (Chur, Switzerland) Vol. 56; no. 1; p. 2259133 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Taylor & Francis Group
01.12.2023
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| Abstract | We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T
) and central memory T cells (T
). CD4+ CD25
Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (T
) and central memory (T
) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells. |
|---|---|
| AbstractList | We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (TEM) and central memory (TCM) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells. We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T ) and central memory T cells (T ). CD4+ CD25 Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (T ) and central memory (T ) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells. We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (TEM) and central memory (TCM) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells.We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (TEM) and central memory (TCM) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells. We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (T EM ) and central memory T cells (T CM ). CD4+ CD25 high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was different than peripherally-induced Treg (pTreg) that revert from pro-inflammatory T cells under repeated stimulatory conditions, suggesting that SARS-CoV-2 spike-specific Treg differentiated from naïve T cells in tissues where the SARS-CoV-2 spike proteins were synthetized. Twenty two of 22 subjects studied responded to vaccination developing a spike-specific CD4+ T helper (Th)1 response, and 20 of 22 developing a spike-specific CD8+ cytotoxic T cells (CTL) response. However, in vaccine recipients the expansion of spike-specific pro-inflammatory T cells was less significant than the expansion of spike-specific Treg. Effector (T EM ) and central memory (T CM ) Treg were numerous as early as after two vaccine doses, with no significant differences following additional vaccine boosts. In co-culture experiments under stimulatory conditions, Treg regulated naïve T cell differentiation toward a pro-inflammatory phenotype and suppressed interferon (IFN)γ production by SARS-CoV-2-specific CD4 + Th1 cells. |
| Author | Chambers, Christina Sette, Alessandro Song, Jaeyoon Grifoni, Alba Franco, Alessandra |
| AuthorAffiliation | a Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA b Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA |
| AuthorAffiliation_xml | – name: a Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA – name: b Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA |
| Author_xml | – sequence: 1 givenname: Alessandra orcidid: 0000-0002-4840-8182 surname: Franco fullname: Franco, Alessandra organization: Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA – sequence: 2 givenname: Jaeyoon surname: Song fullname: Song, Jaeyoon organization: Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA – sequence: 3 givenname: Christina surname: Chambers fullname: Chambers, Christina organization: Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, CA, USA – sequence: 4 givenname: Alessandro surname: Sette fullname: Sette, Alessandro organization: Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA – sequence: 5 givenname: Alba surname: Grifoni fullname: Grifoni, Alba organization: Center for Autoimmunity and Inflammation, Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA |
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| Cites_doi | 10.1371/journal.pone.0186998 10.1074/jbc.AC120.013788 10.1146/annurev-immunol-042718-041717 10.3390/ijms23137219 10.1038/s41590-018-0120-4 10.1016/j.chom.2020.03.002 10.1016/j.cell.2021.01.007 10.3389/fimmu.2022.916411 10.1016/j.cell.2020.05.015 10.1016/j.immuni.2020.12.009 10.1126/science.abm8108 10.1016/j.immuni.2021.04.002 10.1038/nature10957 10.1111/j.1600-065X.2012.01140.x 10.1016/j.jri.2021.103464 10.1002/eji.202149556 10.1126/sciimmunol.abd2071 10.1038/s12276-021-00592-0 10.1182/blood-2011-11-392324 10.1038/nri3464 10.1038/s41590-022-01179-1 10.1016/j.cell.2022.05.022 10.1126/sciimmunol.adg0033 10.1038/s41586-020-2798-3 10.1126/science.abd3871 |
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| Keywords | SARS-CoV-2 Immune regulation Vaccine Regulatory T cells (Treg) T cell memory |
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| References_xml | – ident: e_1_3_4_18_1 doi: 10.1371/journal.pone.0186998 – ident: e_1_3_4_3_1 doi: 10.1074/jbc.AC120.013788 – ident: e_1_3_4_14_1 doi: 10.1146/annurev-immunol-042718-041717 – ident: e_1_3_4_21_1 doi: 10.3390/ijms23137219 – ident: e_1_3_4_13_1 doi: 10.1038/s41590-018-0120-4 – ident: e_1_3_4_16_1 doi: 10.1016/j.chom.2020.03.002 – ident: e_1_3_4_6_1 doi: 10.1016/j.cell.2021.01.007 – ident: e_1_3_4_11_1 doi: 10.3389/fimmu.2022.916411 – ident: e_1_3_4_17_1 doi: 10.1016/j.cell.2020.05.015 – ident: e_1_3_4_9_1 doi: 10.1016/j.immuni.2020.12.009 – ident: e_1_3_4_2_1 doi: 10.1126/science.abm8108 – ident: e_1_3_4_10_1 doi: 10.1016/j.immuni.2021.04.002 – ident: e_1_3_4_23_1 doi: 10.1038/nature10957 – ident: e_1_3_4_15_1 doi: 10.1111/j.1600-065X.2012.01140.x – ident: e_1_3_4_12_1 doi: 10.1016/j.jri.2021.103464 – ident: e_1_3_4_22_1 doi: 10.1002/eji.202149556 – ident: e_1_3_4_20_1 doi: 10.1126/sciimmunol.abd2071 – ident: e_1_3_4_4_1 doi: 10.1038/s12276-021-00592-0 – ident: e_1_3_4_24_1 doi: 10.1182/blood-2011-11-392324 – ident: e_1_3_4_25_1 doi: 10.1038/nri3464 – ident: e_1_3_4_27_1 doi: 10.1038/s41590-022-01179-1 – volume: 518 start-page: 197 year: 2015 ident: e_1_3_4_26_1 article-title: PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection publication-title: Nat Immunol – ident: e_1_3_4_8_1 doi: 10.1016/j.cell.2022.05.022 – ident: e_1_3_4_5_1 doi: 10.1126/sciimmunol.adg0033 – ident: e_1_3_4_7_1 doi: 10.1038/s41586-020-2798-3 – ident: e_1_3_4_19_1 doi: 10.1126/science.abd3871 |
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| SubjectTerms | COVID-19 - prevention & control Humans immune regulation regulatory t cells (treg) SARS-CoV-2 t cell memory T-Lymphocytes, Regulatory Vaccination vaccine Vaccines |
| Title | SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19 |
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