RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 9; p. 986
• Main Authors: Tan, Kai Sen, Andiappan, Anand Kumar, Lee, Bernett, Yan, Yan, Liu, Jing, Tang, See Aik, Lum, Josephine, He, Ting Ting, Ong, Yew Kwang, Thong, Mark, Lim, Hui Fang, Choi, Hyung Won, Rotzschke, Olaf, Chow, Vincent T, Wang, De Yun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.08.2019; MDPI
• Subjects: Animals; Apoptosis; Biopsy; Cell culture; Cell differentiation; Cells, Cultured; Dogs; Drug resistance; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelial Cells - virology; epithelial responses; Epithelium; H3N2 virus; human nasal epithelial cells (hNECs); Humans; Infections; Influenza; Influenza A Virus, H3N2 Subtype - genetics; Influenza, Human - genetics; Influenza, Human - pathology; Influenza, Human - virology; Interferon; Lymphocytes B; Nasal Mucosa - metabolism; Nasal Mucosa - pathology; Nasal Mucosa - virology; Pandemics; pathogenesis; RNA - analysis; RNA - genetics; RNA sequencing; Sequence Analysis, RNA; Signal transduction; Smooth muscle; Statistical analysis; Transcriptomics; Viruses; St Louis Missouri; United States > US; RNA sequencing; human nasal epithelial cells (hNECs); influenza; pathogenesis; H3N2 virus; epithelial responses; transcriptomics

The human nasal epithelium is the primary site of exposure to influenza virus, the initiator of host responses to influenza and the resultant pathologies. Influenza virus may cause serious respiratory infection resulting in major complications, as well as severe impairment of the airways. Here, we e...