The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase bioch...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 2; p. 566
Main Authors Wells, Carrow I, Al-Ali, Hassan, Andrews, David M, Asquith, Christopher R M, Axtman, Alison D, Dikic, Ivan, Ebner, Daniel, Ettmayer, Peter, Fischer, Christian, Frederiksen, Mathias, Futrell, Robert E, Gray, Nathanael S, Hatch, Stephanie B, Knapp, Stefan, Lücking, Ulrich, Michaelides, Michael, Mills, Caitlin E, Müller, Susanne, Owen, Dafydd, Picado, Alfredo, Saikatendu, Kumar S, Schröder, Martin, Stolz, Alexandra, Tellechea, Mariana, Turunen, Brandon J, Vilar, Santiago, Wang, Jinhua, Zuercher, William J, Willson, Timothy M, Drewry, David H
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 08.01.2021
MDPI
Subjects
Annotations
Binding sites
Biology
chemogenomic set
Drug Discovery
Experiments
Humans
Initiatives
KCGS
kinase inhibitor
Kinases
Medical research
Pharmaceutical industry
phenotypic screening
protein kinase
Protein kinase inhibitors
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - therapeutic use
Protein Serine-Threonine Kinases - antagonists & inhibitors
Protein Serine-Threonine Kinases - chemistry
Small Molecule Libraries - chemistry
Small Molecule Libraries - therapeutic use
small molecules
Structure-Activity Relationship
druggable genome
kinase inhibitor
chemogenomic set
drug discovery
KCGS
phenotypic screening
understudied kinase
protein kinase
small molecules
Online AccessGet full text

Cover

Abstract We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
AbstractList We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
Author Al-Ali, Hassan
Gray, Nathanael S
Tellechea, Mariana
Fischer, Christian
Müller, Susanne
Axtman, Alison D
Owen, Dafydd
Mills, Caitlin E
Vilar, Santiago
Saikatendu, Kumar S
Futrell, Robert E
Knapp, Stefan
Frederiksen, Mathias
Lücking, Ulrich
Ettmayer, Peter
Schröder, Martin
Wang, Jinhua
Drewry, David H
Ebner, Daniel
Wells, Carrow I
Stolz, Alexandra
Picado, Alfredo
Asquith, Christopher R M
Andrews, David M
Michaelides, Michael
Willson, Timothy M
Dikic, Ivan
Zuercher, William J
Turunen, Brandon J
Hatch, Stephanie B
AuthorAffiliation 3 Truvitech LLC, Miami, FL 33136, USA; santiago@truvitech.com
16 Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
9 Boehringer Ingelheim RCV GmbH & Co KG, 1121 Vienna, Austria; peter.ettmayer@boehringer-ingelheim.com
14 MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7XB, UK; stephanie.hatch@ndm.ox.ac.uk
17 Bayer Pharma AG, Drug Discovery, Müllerstrasse 178, 13353 Berlin, Germany; ulrich.luecking@forxtherapeutics.com
22 GlaxoSmithKline, Chemical Biology, 1250 S Collegeville Rd, Collegeville, PA 19426, USA; brandon.j.turunen@gsk.com
15 Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany
2 The Miami Project to Cure Paralysis, Peggy and Harold Katz Family Drug Discovery Center, Sylvester Comprehensive Cancer Center, Departments of Neur
AuthorAffiliation_xml – name: 18 Oncology Discovery, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA; michael.michaelides@abbvie.com
– name: 17 Bayer Pharma AG, Drug Discovery, Müllerstrasse 178, 13353 Berlin, Germany; ulrich.luecking@forxtherapeutics.com
– name: 1 Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carrow.i.wells@gsk.com (C.I.W.); chris.asquith@unc.edu (C.R.M.A.); Alison.Axtman@unc.edu (A.D.A.); Robert.e.Futrell@gmail.com (R.E.F.); alfredo.picado@unc.edu (A.P.); william.zuercher@gmail.com (W.J.Z.); Tim.Willson@unc.edu (T.M.W.)
– name: 4 AstraZeneca, Darwin Building, Cambridge Science Park, Cambridge CB4 0WG, UK; David.Andrews@astrazeneca.com
– name: 22 GlaxoSmithKline, Chemical Biology, 1250 S Collegeville Rd, Collegeville, PA 19426, USA; brandon.j.turunen@gsk.com
– name: 5 Institute of Biochemistry 2, Faculty of Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60438 Frankfurt am Main, Germany; dikic@biochem2.uni-frankfurt.de (I.D.); stolz@em.uni-frankfurt.de (A.S.); tellechea@em.uni-frankfurt.de (M.T.)
– name: 10 MSD, 33 Avenue Louis Pasteur, Boston, MA 02115, USA; christian_fischer@merck.com
– name: 13 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
– name: 16 Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
– name: 2 The Miami Project to Cure Paralysis, Peggy and Harold Katz Family Drug Discovery Center, Sylvester Comprehensive Cancer Center, Departments of Neurological Surgery and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA; halali@med.miami.edu
– name: 3 Truvitech LLC, Miami, FL 33136, USA; santiago@truvitech.com
– name: 7 Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany
– name: 9 Boehringer Ingelheim RCV GmbH & Co KG, 1121 Vienna, Austria; peter.ettmayer@boehringer-ingelheim.com
– name: 15 Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany
– name: 20 Discovery Network Group, Pfizer Medicine Design, Cambridge, MA 02139, USA; Dafydd.Owen@pfizer.com
– name: 19 Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Caitlin_Mills@hms.harvard.edu
– name: 12 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Nathanael_Gray@DFCI.HARVARD.EDU (N.S.G.); Jinhua_Wang@DFCI.HARVARD.EDU (J.W.)
– name: 11 Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland; mathias.frederiksen@novartis.com
– name: 8 Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK; daniel.ebner@ndm.ox.ac.uk
– name: 6 Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany; knapp@pharmchem.uni-frankfurt.de (S.K.); susanne.mueller-knapp@bmls.de (S.M.); m.schroeder@pharmchem.uni-frankfurt.de (M.S.)
– name: 21 Global Research Externalization, Takeda California, Inc., 9625 Towne Center Drive, San Diego, CA 92121, USA; kumar.saikatendu@takeda.com
– name: 14 MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7XB, UK; stephanie.hatch@ndm.ox.ac.uk
Author_xml – sequence: 1
  givenname: Carrow I
  orcidid: 0000-0003-4799-6792
  surname: Wells
  fullname: Wells, Carrow I
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 2
  givenname: Hassan
  surname: Al-Ali
  fullname: Al-Ali, Hassan
  organization: Truvitech LLC, Miami, FL 33136, USA
– sequence: 3
  givenname: David M
  orcidid: 0000-0002-6716-6270
  surname: Andrews
  fullname: Andrews, David M
  organization: AstraZeneca, Darwin Building, Cambridge Science Park, Cambridge CB4 0WG, UK
– sequence: 4
  givenname: Christopher R M
  orcidid: 0000-0001-5871-3458
  surname: Asquith
  fullname: Asquith, Christopher R M
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 5
  givenname: Alison D
  orcidid: 0000-0003-4779-9932
  surname: Axtman
  fullname: Axtman, Alison D
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 6
  givenname: Ivan
  surname: Dikic
  fullname: Dikic, Ivan
  organization: Max Planck Institute of Biophysics, Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany
– sequence: 7
  givenname: Daniel
  orcidid: 0000-0002-6495-7026
  surname: Ebner
  fullname: Ebner, Daniel
  organization: Nuffield Department of Medicine, Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, UK
– sequence: 8
  givenname: Peter
  surname: Ettmayer
  fullname: Ettmayer, Peter
  organization: Boehringer Ingelheim RCV GmbH & Co KG, 1121 Vienna, Austria
– sequence: 9
  givenname: Christian
  surname: Fischer
  fullname: Fischer, Christian
  organization: MSD, 33 Avenue Louis Pasteur, Boston, MA 02115, USA
– sequence: 10
  givenname: Mathias
  surname: Frederiksen
  fullname: Frederiksen, Mathias
  organization: Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland
– sequence: 11
  givenname: Robert E
  surname: Futrell
  fullname: Futrell, Robert E
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 12
  givenname: Nathanael S
  surname: Gray
  fullname: Gray, Nathanael S
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
– sequence: 13
  givenname: Stephanie B
  surname: Hatch
  fullname: Hatch, Stephanie B
  organization: MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7XB, UK
– sequence: 14
  givenname: Stefan
  orcidid: 0000-0001-5995-6494
  surname: Knapp
  fullname: Knapp, Stefan
  organization: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
– sequence: 15
  givenname: Ulrich
  surname: Lücking
  fullname: Lücking, Ulrich
  organization: Bayer Pharma AG, Drug Discovery, Müllerstrasse 178, 13353 Berlin, Germany
– sequence: 16
  givenname: Michael
  surname: Michaelides
  fullname: Michaelides, Michael
  organization: Oncology Discovery, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, USA
– sequence: 17
  givenname: Caitlin E
  surname: Mills
  fullname: Mills, Caitlin E
  organization: Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
– sequence: 18
  givenname: Susanne
  orcidid: 0000-0003-2402-4157
  surname: Müller
  fullname: Müller, Susanne
  organization: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
– sequence: 19
  givenname: Dafydd
  surname: Owen
  fullname: Owen, Dafydd
  organization: Discovery Network Group, Pfizer Medicine Design, Cambridge, MA 02139, USA
– sequence: 20
  givenname: Alfredo
  surname: Picado
  fullname: Picado, Alfredo
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 21
  givenname: Kumar S
  surname: Saikatendu
  fullname: Saikatendu, Kumar S
  organization: Global Research Externalization, Takeda California, Inc., 9625 Towne Center Drive, San Diego, CA 92121, USA
– sequence: 22
  givenname: Martin
  surname: Schröder
  fullname: Schröder, Martin
  organization: Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
– sequence: 23
  givenname: Alexandra
  orcidid: 0000-0002-3340-439X
  surname: Stolz
  fullname: Stolz, Alexandra
  organization: Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany
– sequence: 24
  givenname: Mariana
  surname: Tellechea
  fullname: Tellechea, Mariana
  organization: Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany
– sequence: 25
  givenname: Brandon J
  surname: Turunen
  fullname: Turunen, Brandon J
  organization: GlaxoSmithKline, Chemical Biology, 1250 S Collegeville Rd, Collegeville, PA 19426, USA
– sequence: 26
  givenname: Santiago
  surname: Vilar
  fullname: Vilar, Santiago
  organization: Truvitech LLC, Miami, FL 33136, USA
– sequence: 27
  givenname: Jinhua
  surname: Wang
  fullname: Wang, Jinhua
  organization: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
– sequence: 28
  givenname: William J
  orcidid: 0000-0002-9836-0068
  surname: Zuercher
  fullname: Zuercher, William J
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 29
  givenname: Timothy M
  surname: Willson
  fullname: Willson, Timothy M
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
– sequence: 30
  givenname: David H
  orcidid: 0000-0001-5973-5798
  surname: Drewry
  fullname: Drewry, David H
  organization: Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33429995$$D View this record in MEDLINE/PubMed
BookMark eNpdks1rFDEUwINU7IfePMuAlwquZvIdD0JZ2rq0UHCr15Bk3uxmmUnWZEbof--025atp7wkv_yS9_KO0UFMERB6X-MvlGr8NWz6QggmmAvxCh3VjJAZxkIe7MWH6LiUDcaEEq7foENKGdFa8yPU3K6hugrRFqjma-jTCmLqg6-WMFSnV_PL5adv1VmsbrYQq6UPED1UP6GkMU9Bm_LT4d9jFyFbF7ow3FWLBuIQ2uDtEFJ8i163tivw7nE8Qb8uzm_nP2bXN5eL-dn1zDOphpmXzLeOt64GcDUF5bHVrWeitqzRwirqHCOMSG1BtRJPU64td9xhS3GD6Qla7LxNshuzzaG3-c4kG8zDQsorY_MQfAdGK0pJY7nw0jLlwXnKSS2d5MAbT_jk-r5zbUfXQ-OnfLLtXkhf7sSwNqv010hFhFR6Epw-CnL6M0IZTB-Kh66zEdJYDGFSEoEVu7_r43_oZqpvnEr1QFFVU1FP1Ocd5XMqJUP7_Jgam_tWMPutMOEf9hN4hp_-nv4DxQOxPQ
CitedBy_id crossref_primary_10_1021_acs_jmedchem_1c00440
crossref_primary_10_1038_s42004_022_00733_0
crossref_primary_10_1016_j_phrs_2022_106552
crossref_primary_10_1021_acs_jmedchem_1c00845
crossref_primary_10_3390_molecules26195911
crossref_primary_10_1016_j_isci_2023_107209
crossref_primary_10_3390_ijms22169098
crossref_primary_10_3390_pharmaceutics14030515
crossref_primary_10_1021_acs_jmedchem_3c01273
crossref_primary_10_1016_j_ejmech_2024_116357
crossref_primary_10_1016_j_phrs_2021_106037
crossref_primary_10_1016_j_phrs_2021_105463
crossref_primary_10_1002_trc2_12246
crossref_primary_10_1021_acschembio_2c00877
crossref_primary_10_1016_j_phrs_2024_107059
crossref_primary_10_1080_17460441_2022_2114451
crossref_primary_10_1146_annurev_biochem_032620_105344
crossref_primary_10_1016_j_jlr_2022_100187
crossref_primary_10_1016_j_simpa_2022_100257
crossref_primary_10_1039_D2MD00441K
crossref_primary_10_3390_ph14121290
crossref_primary_10_3390_kinasesphosphatases1040017
crossref_primary_10_7554_eLife_86189
crossref_primary_10_1038_s41589_022_01168_3
crossref_primary_10_3390_molecules28072950
crossref_primary_10_1021_acschembio_2c00209
crossref_primary_10_1016_j_drudis_2024_103907
crossref_primary_10_1021_acs_jmedchem_1c00980
crossref_primary_10_3390_molecules27041439
crossref_primary_10_1021_acs_jproteome_3c00182
crossref_primary_10_1002_cbic_202200690
crossref_primary_10_7717_peerj_16342
crossref_primary_10_1016_j_drudis_2024_103881
crossref_primary_10_1038_s41589_023_01459_3
crossref_primary_10_1038_s41467_024_49493_6
crossref_primary_10_1002_ddr_22046
crossref_primary_10_1016_j_drudis_2023_103796
crossref_primary_10_1016_j_phrs_2023_106774
crossref_primary_10_1021_acschembio_2c00378
crossref_primary_10_1039_D1MD00138H
crossref_primary_10_1038_s41467_021_27667_w
crossref_primary_10_3389_fphar_2023_1310135
crossref_primary_10_1126_sciadv_abn3471
crossref_primary_10_1016_j_ejmech_2022_115043
crossref_primary_10_1016_j_slasd_2022_09_004
crossref_primary_10_1002_pld3_460
crossref_primary_10_1002_cpz1_355
crossref_primary_10_1002_trc2_12253
crossref_primary_10_1016_j_phrs_2023_106847
crossref_primary_10_1021_acs_jmedchem_3c02217
Cites_doi 10.1126/science.aan4368
10.15252/embj.201695063
10.1038/nmeth.3853
10.1016/j.dib.2019.104284
10.1016/j.phrs.2019.03.006
10.1038/nbt1068
10.1021/acs.jcim.6b00122
10.1038/nchembio.1867
10.1038/nchembio.297
10.1021/jm901132v
10.1186/s12943-018-0804-2
10.1002/cpch.19
10.1016/j.jns.2019.05.016
10.1126/scitranslmed.aai9055
10.1016/j.molcel.2016.09.037
10.1007/s11033-018-4222-8
10.1038/s41580-018-0003-4
10.1016/j.chembiol.2017.10.010
10.1016/j.phrs.2019.104609
10.3390/ijms18091884
10.1038/470163a
10.1038/nrd.2018.52
10.1177/2472555219838210
10.1038/nbt.3374
10.1021/jm901371v
10.1038/aps.2016.136
10.18632/oncotarget.9766
10.1016/j.chembiol.2019.03.011
10.1021/jm101195a
10.1007/978-981-15-0602-4_3
10.1101/104711
10.1038/nrd.2018.21
10.1021/jm8011036
10.1038/nrd.2016.244
10.15252/embj.2018101443
10.1016/j.drudis.2019.06.020
10.1093/brain/awaa022
10.1007/s10741-017-9634-3
10.1038/nchembio.1113
10.1126/science.1075762
10.1177/2472555220923979
10.1038/srep42717
10.1016/j.chembiol.2019.02.018
10.1080/14737140.2018.1527688
ContentType Journal Article
Copyright 2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 by the authors. 2021
Copyright_xml – notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 by the authors. 2021
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3390/ijms22020566
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
ProQuest research library
Research Library (Corporate)
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef
MEDLINE

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID oai_doaj_org_article_98332da56c7a48cebc35217b75e5dc25
10_3390_ijms22020566
33429995
Genre Journal Article
GrantInformation_xml – fundername: NIH HHS
  grantid: 1R44TR001916-02
– fundername: Innovative Medicines Initiative
  grantid: 875510
– fundername: NIH HHS
  grantid: 1R01CA218442-01
– fundername: NIH HHS
  grantid: 1U24DK116204-01
– fundername: NCI NIH HHS
  grantid: R01 CA218442
– fundername: NCATS NIH HHS
  grantid: R03 TR003386
GroupedDBID ---
29J
2WC
3V.
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
ABDBF
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CGR
CS3
CUY
CVF
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
ECM
EIF
EJD
ESTFP
ESX
F5P
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
ITC
KB.
KQ8
LK8
M1P
M2O
M48
M7P
MODMG
M~E
NPM
O5R
O5S
OK1
P2P
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNS
RPM
TR2
TUS
UKHRP
~8M
AAYXX
CITATION
7XB
8FK
ACUHS
IHR
K9.
MBDVC
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c478t-c74cfb5fb1eeb13e8c0a9fc461a4d96a83bb424279ae8f703bb59a5b5b0a30d03
IEDL.DBID RPM
ISSN 1422-0067
1661-6596
IngestDate Tue Oct 22 15:06:49 EDT 2024
Tue Sep 17 21:11:53 EDT 2024
Wed Dec 04 06:40:14 EST 2024
Sun Dec 15 07:30:10 EST 2024
Fri Dec 06 09:24:49 EST 2024
Sat Nov 02 12:28:51 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords druggable genome
kinase inhibitor
chemogenomic set
drug discovery
KCGS
phenotypic screening
understudied kinase
protein kinase
small molecules
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-c74cfb5fb1eeb13e8c0a9fc461a4d96a83bb424279ae8f703bb59a5b5b0a30d03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-6716-6270
0000-0003-4779-9932
0000-0002-6495-7026
0000-0001-5995-6494
0000-0003-4799-6792
0000-0003-2402-4157
0000-0002-3340-439X
0000-0002-9836-0068
0000-0001-5871-3458
0000-0001-5973-5798
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826789/
PMID 33429995
PQID 2477381361
PQPubID 2032341
ParticipantIDs doaj_primary_oai_doaj_org_article_98332da56c7a48cebc35217b75e5dc25
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7826789
proquest_miscellaneous_2477260845
proquest_journals_2477381361
crossref_primary_10_3390_ijms22020566
pubmed_primary_33429995
PublicationCentury 2000
PublicationDate 20210108
PublicationDateYYYYMMDD 2021-01-08
PublicationDate_xml – month: 1
  year: 2021
  text: 20210108
  day: 8
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2021
Publisher MDPI AG
MDPI
Publisher_xml – sequence: 0
  name: MDPI AG
– name: MDPI
– name: MDPI AG
References Arrowsmith (ref_10) 2015; 11
ref_19
ref_16
Oprea (ref_7) 2018; 17
Bhullar (ref_46) 2018; 17
Hafner (ref_34) 2017; 9
Guttuso (ref_50) 2019; 402
Stolz (ref_35) 2017; 36
Kannaiyan (ref_47) 2018; 18
Knapp (ref_4) 2013; 9
Ferguson (ref_3) 2018; 17
Zwick (ref_24) 2019; 25
ref_22
ref_20
Sarikaya (ref_38) 2018; 45
Roskoski (ref_28) 2019; 144
Zhou (ref_39) 2017; 38
Drewry (ref_17) 2019; 24
Manning (ref_23) 2002; 298
ref_26
Bamborough (ref_13) 2008; 51
Kaizuka (ref_37) 2016; 64
Vasta (ref_43) 2018; 25
Varma (ref_29) 2010; 53
ref_33
Posy (ref_14) 2011; 54
Wang (ref_41) 2019; 1206
Guo (ref_49) 2020; 143
Carter (ref_25) 2019; 24
Papadatos (ref_9) 2016; 56
Singh (ref_51) 2017; 22
Howarth (ref_31) 2020; 25
Jones (ref_11) 2017; 16
Liu (ref_40) 2017; 9
Dikic (ref_36) 2018; 19
ref_45
ref_44
Gautam (ref_12) 2019; 26
ref_42
Fedorov (ref_5) 2010; 6
ref_1
Daina (ref_27) 2017; 7
Fabian (ref_21) 2005; 23
Edwards (ref_6) 2011; 470
Moret (ref_18) 2019; 26
ref_48
Elkins (ref_15) 2016; 34
ref_8
Hafner (ref_32) 2016; 13
Morphy (ref_2) 2010; 53
Montenegro (ref_30) 2016; 7
References_xml – ident: ref_8
  doi: 10.1126/science.aan4368
– volume: 36
  start-page: 549
  year: 2017
  ident: ref_35
  article-title: Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins
  publication-title: EMBO J.
  doi: 10.15252/embj.201695063
  contributor:
    fullname: Stolz
– volume: 13
  start-page: 521
  year: 2016
  ident: ref_32
  article-title: Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3853
  contributor:
    fullname: Hafner
– ident: ref_26
– volume: 25
  start-page: 104284
  year: 2019
  ident: ref_24
  article-title: Dataset of the frequency patterns of publications annotated to human protein-coding genes, their protein products and genetic relevance
  publication-title: Data Brief
  doi: 10.1016/j.dib.2019.104284
  contributor:
    fullname: Zwick
– volume: 144
  start-page: 19
  year: 2019
  ident: ref_28
  article-title: Properties of FDA-approved small molecule protein kinase inhibitors
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2019.03.006
  contributor:
    fullname: Roskoski
– volume: 23
  start-page: 329
  year: 2005
  ident: ref_21
  article-title: A small molecule-kinase interaction map for clinical kinase inhibitors
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1068
  contributor:
    fullname: Fabian
– volume: 56
  start-page: 1654
  year: 2016
  ident: ref_9
  article-title: Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?
  publication-title: J. Chem. Inf. Model.
  doi: 10.1021/acs.jcim.6b00122
  contributor:
    fullname: Papadatos
– volume: 11
  start-page: 536
  year: 2015
  ident: ref_10
  article-title: The promise and peril of chemical probes
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1867
  contributor:
    fullname: Arrowsmith
– volume: 6
  start-page: 166
  year: 2010
  ident: ref_5
  article-title: The (un)targeted cancer kinome
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.297
  contributor:
    fullname: Fedorov
– volume: 53
  start-page: 1413
  year: 2010
  ident: ref_2
  article-title: Selectively nonselective kinase inhibition: Striking the right balance
  publication-title: J. Med. Chem.
  doi: 10.1021/jm901132v
  contributor:
    fullname: Morphy
– volume: 17
  start-page: 48
  year: 2018
  ident: ref_46
  article-title: Kinase-Targeted cancer therapies: Progress, challenges and future directions
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-018-0804-2
  contributor:
    fullname: Bhullar
– volume: 9
  start-page: 96
  year: 2017
  ident: ref_34
  article-title: Designing Drug-Response Experiments and Quantifying their Results
  publication-title: Curr. Protoc. Chem. Biol.
  doi: 10.1002/cpch.19
  contributor:
    fullname: Hafner
– volume: 402
  start-page: 121
  year: 2019
  ident: ref_50
  article-title: Targeting kinases in Parkinson’s disease: A mechanism shared by LRRK2, neurotrophins, exenatide, urate, nilotinib and lithium
  publication-title: J. Neurol. Sci.
  doi: 10.1016/j.jns.2019.05.016
  contributor:
    fullname: Guttuso
– ident: ref_19
  doi: 10.1126/scitranslmed.aai9055
– volume: 64
  start-page: 835
  year: 2016
  ident: ref_37
  article-title: An Autophagic Flux Probe That Releases an Internal Control
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2016.09.037
  contributor:
    fullname: Kaizuka
– volume: 45
  start-page: 815
  year: 2018
  ident: ref_38
  article-title: Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-018-4222-8
  contributor:
    fullname: Sarikaya
– volume: 19
  start-page: 349
  year: 2018
  ident: ref_36
  article-title: Mechanism and medical implications of mammalian autophagy
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-018-0003-4
  contributor:
    fullname: Dikic
– volume: 25
  start-page: 206
  year: 2018
  ident: ref_43
  article-title: Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2017.10.010
  contributor:
    fullname: Vasta
– ident: ref_1
  doi: 10.1016/j.phrs.2019.104609
– ident: ref_42
  doi: 10.3390/ijms18091884
– ident: ref_45
– volume: 470
  start-page: 163
  year: 2011
  ident: ref_6
  article-title: Too many roads not taken
  publication-title: Nature
  doi: 10.1038/470163a
  contributor:
    fullname: Edwards
– volume: 17
  start-page: 377
  year: 2018
  ident: ref_7
  article-title: Unexplored therapeutic opportunities in the human genome
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2018.52
  contributor:
    fullname: Oprea
– volume: 24
  start-page: 505
  year: 2019
  ident: ref_17
  article-title: A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction
  publication-title: SLAS Discov.
  doi: 10.1177/2472555219838210
  contributor:
    fullname: Drewry
– ident: ref_20
– volume: 34
  start-page: 95
  year: 2016
  ident: ref_15
  article-title: Comprehensive characterization of the Published Kinase Inhibitor Set
  publication-title: Nat. Biotech.
  doi: 10.1038/nbt.3374
  contributor:
    fullname: Elkins
– volume: 53
  start-page: 1098
  year: 2010
  ident: ref_29
  article-title: Physicochemical space for optimum oral bioavailability: Contribution of human intestinal absorption and first-pass elimination
  publication-title: J. Med. Chem.
  doi: 10.1021/jm901371v
  contributor:
    fullname: Varma
– volume: 38
  start-page: 513
  year: 2017
  ident: ref_39
  article-title: The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2016.136
  contributor:
    fullname: Zhou
– volume: 7
  start-page: 43997
  year: 2016
  ident: ref_30
  article-title: BET inhibition as a new strategy for the treatment of gastric cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.9766
  contributor:
    fullname: Montenegro
– volume: 26
  start-page: 970
  year: 2019
  ident: ref_12
  article-title: Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.03.011
  contributor:
    fullname: Gautam
– volume: 54
  start-page: 54
  year: 2011
  ident: ref_14
  article-title: Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening
  publication-title: J. Med. Chem.
  doi: 10.1021/jm101195a
  contributor:
    fullname: Posy
– volume: 1206
  start-page: 67
  year: 2019
  ident: ref_41
  article-title: Regulation of Autophagy by mTOR Signaling Pathway
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-981-15-0602-4_3
  contributor:
    fullname: Wang
– ident: ref_16
  doi: 10.1101/104711
– volume: 17
  start-page: 353
  year: 2018
  ident: ref_3
  article-title: Kinase inhibitors: The road ahead
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2018.21
  contributor:
    fullname: Ferguson
– volume: 51
  start-page: 7898
  year: 2008
  ident: ref_13
  article-title: Assessment of chemical coverage of kinome space and its implications for kinase drug discovery
  publication-title: J. Med. Chem.
  doi: 10.1021/jm8011036
  contributor:
    fullname: Bamborough
– volume: 16
  start-page: 285
  year: 2017
  ident: ref_11
  article-title: Applications of chemogenomic library screening in drug discovery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.244
  contributor:
    fullname: Jones
– ident: ref_48
  doi: 10.15252/embj.2018101443
– volume: 24
  start-page: 2111
  year: 2019
  ident: ref_25
  article-title: Target 2035: Probing the human proteome
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2019.06.020
  contributor:
    fullname: Carter
– ident: ref_44
– volume: 143
  start-page: 1651
  year: 2020
  ident: ref_49
  article-title: The multifaceted role of kinases in amyotrophic lateral sclerosis: Genetic, pathological and therapeutic implications
  publication-title: Brain
  doi: 10.1093/brain/awaa022
  contributor:
    fullname: Guo
– volume: 22
  start-page: 843
  year: 2017
  ident: ref_51
  article-title: Protein kinase C and cardiac dysfunction: A review
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-017-9634-3
  contributor:
    fullname: Singh
– volume: 9
  start-page: 845
  year: 2017
  ident: ref_40
  article-title: Alisertib induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cells
  publication-title: Am. J. Transl. Res.
  contributor:
    fullname: Liu
– ident: ref_33
– volume: 9
  start-page: 3
  year: 2013
  ident: ref_4
  article-title: A public-private partnership to unlock the untargeted kinome
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1113
  contributor:
    fullname: Knapp
– volume: 298
  start-page: 1912
  year: 2002
  ident: ref_23
  article-title: The Protein Kinase Complement of the Human Genome
  publication-title: Science
  doi: 10.1126/science.1075762
  contributor:
    fullname: Manning
– volume: 25
  start-page: 801
  year: 2020
  ident: ref_31
  article-title: HighVia—A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity
  publication-title: SLAS Discov.
  doi: 10.1177/2472555220923979
  contributor:
    fullname: Howarth
– volume: 7
  start-page: 42717
  year: 2017
  ident: ref_27
  article-title: SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
  publication-title: Sci. Rep.
  doi: 10.1038/srep42717
  contributor:
    fullname: Daina
– ident: ref_22
– volume: 26
  start-page: 765
  year: 2019
  ident: ref_18
  article-title: Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.02.018
  contributor:
    fullname: Moret
– volume: 18
  start-page: 1249
  year: 2018
  ident: ref_47
  article-title: A comprehensive review of protein kinase inhibitors for cancer therapy
  publication-title: Expert. Rev. Anticancer Ther.
  doi: 10.1080/14737140.2018.1527688
  contributor:
    fullname: Kannaiyan
SSID ssj0023259
Score 2.558428
Snippet We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 566
SubjectTerms Annotations
Binding sites
Biology
chemogenomic set
Drug Discovery
Experiments
Humans
Initiatives
KCGS
kinase inhibitor
Kinases
Medical research
Pharmaceutical industry
phenotypic screening
protein kinase
Protein kinase inhibitors
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - therapeutic use
Protein Serine-Threonine Kinases - antagonists & inhibitors
Protein Serine-Threonine Kinases - chemistry
Small Molecule Libraries - chemistry
Small Molecule Libraries - therapeutic use
small molecules
Structure-Activity Relationship
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWqSpV6QVAKLJTKSEWCQ9TE3-bWVi1Vq3IpRb1FHmciFtEsoruH_nvGcbLaRZW4cI3tyJnJ5L1xxs-MHaD2lMoqKFCjLBR4KMAHW1QVxCaAEK1Nu5GvvpjzG3Vxq29XjvpKNWFZHjgb7tA7KUUTtIk2KBcRIlGGyoLVqJsosnppKcZkaki1pOiPSasIfQqjvckl75IS_MPpj7t7QSk_Ib9ZA6Nes_8xovl3veQKAJ09ZU8G5siP8oyfsQ3sdthWPkvy4TlryOH8ctoRKvGkAjBL6qt308ivcc4_XJ58vv74iR91PFWQ8CGi-bh4z4m6joO_LX4mJeq-aPaB54287bCyt8tuzk6_npwXwxEKRVTWzYtoVWxBt1AhfZQlulgG30ZlqqAab4KTAIpQ2vqArqXoB9A-aNBQBlk2pXzBNrtZh68Yr6SJIuroDNKQKMBjYzAp4qFviRRN2PvRlvWvrJRRU4aRbF6v2nzCjpOhl32SvnV_gbxeD16v_-X1Cdsb3VQPQXdfC2UtERBpqgl7t2ymcEn_QEKHs0XuQymcU3SLl9mry5lImcDZU4td8_faVNdbuun3XpKbeBahvn_9P57tDdsWqXAmrfO4PbY5_73At8R85rDfv-R_AIlbAaM
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dTxQxEG8QYuKLUfw6RFMTSfSh4bbf9cUg8SASeAEMb5tOt6tnZBe4uwf-e6e73ZMzhtdtu2lmOvObmU5nCHkflUNXVgKLKgomwQED5w0rCgiVB85rk14jH5_ow3P57UJd5IDbLKdVDjqxU9RVG1KMfJdLYxBdhC4-X12z1DUq3a7mFhoPyEbBjU4pfXZysHS4BO-apRWIQUwrp_vEd4Fu_u701-WMo-OP-K9XIKmr3P8_c_PfrMk7MDR5Qh5n-5Hu9Qx_StZis0ke9h0lb5-RCtlOj6YNYhNNtQDaVIP1chroaZzTD0f7B6cfP9G9hqY8Eprlmg4hfIoG7LD4--J3qkfdpc7e0v45b53je8_J-eTr2f4hy40UWJDGzlkwMtSgaigiqmYRbRh7VwepCy8rp70VABKx2jgfbY06AEA5r0DB2ItxNRYvyHrTNvEVociAwIMKVkdcEji4WOmY6uJFV6NpNCI7Ay3Lq75eRol-RqJ5eZfmI_IlEXo5J1W57j60Nz_KLDSls0LwyisdjJc2RAhoLhYGjIqqClyNyPbApjKL3qz8e1BG5N1yGIUm3YT4JraLfg46clbiL172XF3uRIgE0Q5HzAq_V7a6OtJMf3aFudHaQux3W_dv6zV5xFNiTIrj2G2yPr9ZxDdo2czhbXd8_wD7Wfj7
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3daxQxEA-1UvBF_Kj2tEoEBfuw7W2-I4jUYi2W-tKe9G3JZGfrSbun1zvw_nsn-3H0tA--bpLdZSaT32-SyQxjr1F7cmUVZKhRZgo8ZOCDzfIcYhlAiMqm28gnX83RSH051-drrK822gnw-lbXLtWTGk0vd3__Wnwgg3-fPE5y2ffGP66uBTnxhOXmDrsrCBNTcNeJWp4nEG3Qvg17_2fECiA1eftvI5t_x0zeAKHDB-x-xx75fqvuh2wN60dso60nuXjMSlI6Px7XhEw8ZQKYpAysV-PIT3HG3x4ffD7decf3a56iSHhn1bzfwOdEX_vB3-aXKRt1Ezi74O1l3qrb3dtko8NPZwdHWVdGIYvKulkWrYoV6ApypIVZoovD4KuoTB5U6U1wEkARUlsf0FW0AgBoHzRoGAY5LIfyCVuvJzVuMZ5LE0XU0RmkIVGAx9JgyoqHviJiNGBvelkWP9tsGQV5GUnmxU2ZD9jHJOhln5TjunkwmV4UnckU3kkpyqBNtEG5iBCJLOYWrEZdRqEHbLtXU9HPm0Ioa4mESJMP2KtlM5lMOgcJNU7mbR9y45yiVzxttbr8EykTQHtqsSv6XvnV1ZZ6_L1Jy01ci5DfP_uP7z5n90SKjUlbOW6brc-mc3xB5GYGL5t5-wc_nfvQ
  priority: 102
  providerName: Scholars Portal
Title The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
URI https://www.ncbi.nlm.nih.gov/pubmed/33429995
https://www.proquest.com/docview/2477381361
https://search.proquest.com/docview/2477260845
https://pubmed.ncbi.nlm.nih.gov/PMC7826789
https://doaj.org/article/98332da56c7a48cebc35217b75e5dc25
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFH_ahpC4IL4JjMpIIMEhaxPbsc1tq9ZNTJ0mxlBvkZ_jQNCaTlt72H_Pcz6qFnHikkNsR9b78O89530AfPDSkCsrMPbS81igwRiNVXGSoCsspmmpQjby9Dw7vRJfZ3K2A7LPhWmC9h1WB_X1_KCufjWxlTdzN-zjxIYX0zGhGp2xZrgLuwS_vYveeVmcDPo2wp2TPz-sfs_vUvLwCehDuyLOwwEcuklswFBTrf9fJubfkZIb0DN5Ao87m5Edtnt7Cju-fgYP2y6S98-hIFazs6omPGIh_38R6q7OK8cu_ZJ9OhufXH7-wg5rFmJHWKfLrL-2Z2S09ot_rK5DDeomXPaetSm8ZXen9wKuJsffx6dx1zwhdkLpZeyUcCXKEhNPxzH32o2sKZ3IEisKk1nNEQXhszLW65L0HlEaK1HiyPJRMeIvYa9e1P41sIRnLnXS6czTEpei8UXmQy08b0oyhyL42NMyv2lrZOTkWwTy55vkj-AoEHo9J1S2bl4sbn_mHX9zozlPCyszp6zQzqMjEzFRqKSXhUtlBPs9m_JO3e7yVChFpgfPkgjer4dJUcLfD1v7xaqdQ86bFvSJVy1X1zvppSICtcXvra1uj5BsNsW4O1l8898r38KjNMTJhGsdvQ97y9uVf0eGzhIHJN4zRU89ORnAg6Pj84tvg-bSYBAASNJzKvSgEf8_eYsGZQ
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,12765,21388,24318,27924,27925,31719,31720,33373,33374,33744,33745,43310,43600,43805,53791,53793,73745,74035,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJwQviG8KA4wEEjxEa_xtXtA2bRS6VYhtaG-R7ThQxJKxtg_77zknTlkR4jW2I-vO9-nz7wBeBWEwlOUuCyKwjDvjMmesyvLc-dI6SisVXyMfTuX4hH86Facp4TZPZZW9TmwVddn4mCPfolwptC5M5u_Pf2Wxa1S8XU0tNK7DRkROFwPY2Nmbfv6yCrkYbdul5WiFMimM7ErfGQb6W7MfZ3OKoT96AHLNKLXY_f9yOP-um7xiiPbvwO3kQZLtjuV34Vqo78GNrqfk5X0okfFkMqvROpGIBtBEFNazmSdHYUHeTHY_HL19R7ZrEitJSJJs0ifxCbqw_eKvy58Rkbotnr0k3YPeKmX4HsDJ_t7x7jhLrRQyz5VeZF5xXzlRuTygcmZB-5E1lecyt7w00mrmHEdrrYwNukIt4JwwVjjhRpaNyhF7CIO6qcNjIMgCT73wWgZc4qkzoZQhIuMFU6FzNITXPS2L8w4xo8BII9K8uErzIexEQq_mRJzr9kNz8a1IYlMYzRgtrZBeWa59cB4dxlw5JYIoPRVD2OzZVCThmxd_jsoQXq6GUWziXYitQ7Ps5mAopzn-4lHH1dVOGItG2uCIWuP32lbXR-rZ9xaaG_0ttP7myf-39QJujo8PD4qDj9PJU7hFY5lMzOroTRgsLpbhGfo5C_c8HebfBGv9TA
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELegE4gXxDeFAUYCCR6sJv42L2gbK4NCNTGG9hbZjrMVsWSs7cP-e86J060I8RrbkeWz7353Pv8OoVdBGHBluSNBBEa4M444YxXJc-dL6yitVHyN_HUq9w755yNxlPKf5imtsteJraIuGx9j5CPKlQLrwmQ-qlJaxP6H8fuz3yRWkIo3ramcxnW0AVYxowO0sb073f-2cr8YbUun5WCRiBRGdmnwDJz-0ezn6ZxSQE6iZUu8NFAtj_-_wOffOZRXjNL4Drqd0CTe6sR_F10L9T10o6sveXEflbAJ8GRWg6XCkRmgiYyspzOPD8ICv5nsfDx4-w5v1ThmleB0ynEf0McAZ_vBP5a_Ijt1m0h7gbvHvVWK9j1Ah-Pd7zt7JJVVIJ4rvSBecV85Ubk8gKJmQfvMmspzmVteGmk1c46D5VbGBl2BRnBOGCuccJllWZmxh2hQN3V4jDCIw1MvvJYBhnjqTChliCx5wVQAlIbodb-WxVnHnlGA1xHXvLi65kO0HRd61SdyXrcfmvPjIh2hwmjGaGmF9Mpy7YPzAB5z5ZQIovRUDNFmL6YiHcR5cblthujlqhmOULwXsXVoll0fcOs0h1886qS6mglj0WAbaFFr8l6b6npLPTtpaboBewESME_-P60X6Cbs4-LLp-nkKbpFY8ZMDPDoTTRYnC_DM4A8C_c87eU_wCoBiA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Kinase+Chemogenomic+Set+%28KCGS%29%3A+An+Open+Science+Resource+for+Kinase+Vulnerability+Identification&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Wells%2C+Carrow+I&rft.au=Al-Ali%2C+Hassan&rft.au=Andrews%2C+David+M&rft.au=Asquith%2C+Christopher+R+M&rft.date=2021-01-08&rft.eissn=1422-0067&rft.volume=22&rft.issue=2&rft_id=info:doi/10.3390%2Fijms22020566&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon