Cyclic AMP response element-binding protein in post-mortem brain of teenage suicide victims: specific decrease in the prefrontal cortex but not the hippocampus

• Published in: The international journal of neuropsychopharmacology Vol. 10; no. 5; pp. 621 - 629
• Main Authors: Pandey, Ghanshyam N., Dwivedi, Yogesh, Ren, Xinguo, Rizavi, Hooriyah S., Roberts, Rosalinda C., Conley, Robert R.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.10.2007; Oxford University Press
• Subjects: Adolescent; Adult; Analysis of Variance; Binding sites; Changes; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Enzymes; Female; Gene Expression Regulation - physiology; Hippocampus - metabolism; Humans; Kinases; Male; Mental health care; Neurosciences; Postmortem Changes; Prefrontal Cortex - metabolism; Protein expression; Proteins; Reverse Transcriptase Polymerase Chain Reaction - methods; Risk factors; RNA, Messenger - metabolism; Signal transduction; Studies; Suicide; Suicides & suicide attempts; Tissues; Transcription factors; post-mortem brain; CREB; suicide; mRNA; teenage; immunolabelling; DNA binding

Abnormalities in both adenylyl cyclase (AC) and phosphoinositide (PI) signalling systems have been observed in the post-mortem brain of suicide victims. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is activated by phosphorylating enzymes such as protein kinase A...