Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 4; p. 534
• Main Authors: Santiago-Fernández, Concepción, Martin-Reyes, Flores, Tome, Mónica, Ocaña-Wilhelmi, Luis, Rivas-Becerra, Jose, Tatzber, Franz, Pursch, Edith, Tinahones, Francisco J., García-Fuentes, Eduardo, Garrido-Sánchez, Lourdes
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2020; MDPI
• Subjects: adipocyte; Adipocytes - cytology; Adipocytes - drug effects; Adipocytes - metabolism; Adipose tissue; Adult; Apoptosis; Apoptosis - drug effects; Autophagy - drug effects; Biological Transport; Biomarkers - metabolism; Cell Differentiation - drug effects; Cholesterol - chemistry; Cholesterol - metabolism; Esterification; Female; Genetic aspects; Health aspects; Humans; inflammation; Inflammation - chemically induced; Inflammation - pathology; Insulin Resistance; Lipoproteins, LDL - metabolism; Lipoproteins, LDL - pharmacology; Low density lipoproteins; Male; oxidized low-density lipoprotein; Phenotype; Phenotypes; scavenger receptors; Spain; apoptosis; oxidized low-density lipoprotein; inflammation; adipocyte; scavenger receptors

Little information exists in humans on the regulation that oxidized low-density lipoprotein (oxLDL) exerts on adipocyte metabolism, which is associated with obesity and type 2 diabetes. The aim was to analyze the oxLDL effects on adipocytokine secretion and scavenger receptors (SRs) and cell death m...