The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice

• Published in: Pharmacology, biochemistry and behavior Vol. 83; no. 3; pp. 349 - 359
• Main Authors: Shepherd, K. Raviie, Lee, Eun-Sook Y., Schmued, Larry, Jiao, Yun, Ali, Syed F., Oriaku, Ebenezer T., Lamango, Nazarius S., Soliman, Karam F.A., Charlton, Clivel G.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2006; Elsevier Science
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage; 3,4-Dihydroxyphenylacetic Acid - metabolism; Adult and adolescent clinical studies; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine; Dopamine - chemistry; Dopamine - metabolism; Drug Synergism; Herbicides - administration & dosage; Herbicides - toxicity; Homovanillic Acid - metabolism; Humans; Male; Medical sciences; Methylation; Mice; Mice, Inbred C57BL; Motor Activity - drug effects; MPTP; MPTP Poisoning - etiology; MPTP Poisoning - metabolism; MPTP Poisoning - psychology; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Neurotoxins - administration & dosage; Neurotoxins - toxicity; Organic mental disorders. Neuropsychology; Paraquat; Paraquat - administration & dosage; Paraquat - toxicity; Parkinson's disease; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Paraquat; Parkinson's disease; Dopamine; MPTP; Methylation; Nervous system diseases; Rodentia; Behavior change; Parkinson disease; Catecholamine; Cerebral disorder; Toxin; Vertebrata; Mammalia; Mouse; Animal; Central nervous system disease; Neurotoxin; Neurotransmitter; Degenerative disease; Extrapyramidal syndrome

Although the etiology of Parkinson's disease (PD) is not fully understood, there are numerous studies that have linked the increased risk for developing PD to pesticides exposure including paraquat (PQ). Moreover, the exposure to a combination of compounds or chemical mixtures has been suggeste...