Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 10; p. 1238
• Main Authors: Falk, Nathalie, Joachimsthaler, Anneka, Kessler, Kristin, Lux, Uwe Thorsten, Noegel, Angelika Anna, Kremers, Jan, Brandstätter, Johann Helmut, Gießl, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.10.2019; MDPI
• Subjects: Actin; Alternative splicing; Animals; Antibodies; Binding sites; ciliogenesis; Cytoskeleton; Ethanol; Experiments; Filaments; Laboratories; Localization; Microscopy; Molecular weight; nuclear migration; pericentrin; Phenotypes; Photoreceptors; primary cilium; Proteins; Retina; Stains & staining; syne-2; United States > US; Germany; primary cilium; nuclear migration; Syne-2; ciliogenesis; retina; Pericentrin

Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments. Syne-2 contains a C-terminal KASH transmembrane domain and is part of a protein network that associates the nuclear envelope to the...