Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

• Published in: Life (Basel, Switzerland) Vol. 10; no. 12; p. 337
• Main Authors: Kolhe, Ravindra, Owens, Virgenal, Sharma, Ashok, Lee, Tae Jin, Zhi, Wenbo, Ghilzai, Umar, Mondal, Ashis K, Liu, Yutao, Isales, Carlos M, Hamrick, Mark W, Hunter, Monte, Fulzele, Sadanand
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.12.2020; MDPI
• Subjects: Acetyltransferase; Acids; Age; Age related diseases; Annotations; Apolipoproteins; Arthritis; Biomarkers; Biomedical materials; Brief Report; Cargo; cartilage degeneration; Ceruloplasmin; Diabetes; Disease; exosomes; Gender; Glycoproteins; Haptoglobin; Inflammation; Males; Mass spectrometry; miRNA; Osteoarthritis; Paracrine signalling; Pathogenesis; Patients; Peptides; Protein expression; Proteins; Scientific imaging; Sex; Signaling; Statistical analysis; Synovial fluid; Womens health; United States > US; mass spectrometry; cartilage degeneration; gender; exosomes

Women are at a significantly higher risk of developing osteoarthritis (OA) compared to males. The pathogenesis of osteoarthritis (OA) in women is poorly understood. Extracellular vesicles (EVs) have been shown to play an essential role in numerous signaling processes during the pathogenesis of age-r...