Targeting endothelial thioredoxin-interacting protein (TXNIP) protects from metabolic disorder-related impairment of vascular function and post-ischemic revascularisation

• Published in: Angiogenesis (London) Vol. 23; no. 2; pp. 249 - 264
• Main Authors: Domingues, Alison, Boisson-Vidal, Catherine, Marquet de Rouge, Perrine, Dizier, Blandine, Sadoine, Jérémy, Mignon, Virginie, Vessières, Emilie, Henrion, Daniel, Escriou, Virginie, Bigey, Pascal, Chaussain, Catherine, Smadja, David M., Nivet-Antoine, Valérie
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2020; Springer Nature B.V; Springer Verlag
• Subjects: Angiogenesis; Animal models; Animals; Aorta; Biomedical and Life Sciences; Biomedicine; Blood flow; Blood vessels; Cancer Research; Carbohydrates; Cardiology; Cardiology and cardiovascular system; Carrier Proteins - genetics; Cell Biology; Cells, Cultured; Cellular Biology; Complications; Cytoprotection - genetics; Diet; Endothelial cells; Endothelial Cells - physiology; High carbohydrate diet; High protein diet; Hindlimb - blood supply; Human health and pathology; Impairment; In vivo methods and tests; Ischemia; Ischemia - genetics; Ischemia - metabolism; Ischemia - physiopathology; Ischemia - prevention & control; Life Sciences; Low carbohydrate diet; Low protein diet; Male; Metabolic Diseases - complications; Metabolic Diseases - genetics; Metabolic Diseases - metabolism; Metabolic Diseases - physiopathology; Metabolic disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic - genetics; Nutrient deficiency; Oncology; Ophthalmology; Original Paper; Oxidative stress; Oxidative Stress - physiology; Proteins; siRNA; Subcellular Processes; Therapeutic applications; Thioredoxin; Thioredoxins - genetics; Endothelial dysfunction; Oxidative stress; TXNIP; Arterial damage; Metabolic disorders; Post-ischemic revascularisation

Introduction Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endo...