HMGB1, IL-1α, IL-33 and S100 proteins： dual-function alarmins

• Published in: Cellular & molecular immunology Vol. 14; no. 1; pp. 43 - 64
• Main Authors: Bertheloot, Damien, Latz, Eicke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2017; Nature Publishing Group
• Subjects: Alarmins - metabolism; Animals; Antibodies; Biomedical and Life Sciences; Biomedicine; HMGB1; HMGB1 Protein - metabolism; Humans; IL-1α; Immunology; Interleukin-1alpha - metabolism; Interleukin-33 - metabolism; Medical Microbiology; Microbiology; Models, Biological; Review; S100 Proteins - metabolism; S100蛋白; Vaccine; 免疫系统; 快速检测; 生殖细胞; 组织损伤; 细胞死亡; alarmin; HMGB1; S100 proteins; inflammation; IL-1α; IL-33

Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as ef...