The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

• Published in: Progress in lipid research Vol. 61; pp. 30 - 39
• Main Authors: Chiapparino, Antonella, Maeda, Kenji, Turei, Denes, Saez-Rodriguez, Julio, Gavin, Anne-Claude
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2016
• Subjects: Animals; Biological membranes; Biomolecular networks; Carrier Proteins - physiology; Cell Membrane - physiology; Endoplasmic Reticulum - physiology; Golgi Apparatus - physiology; Humans; Lipid Metabolism; Lipid-binding domains; Lipid-transfer proteins; Membrane contact sites; Metabolism; Non-vesicular lipid trafficking; Organelles; Protein Transport; Signal Transduction; Signaling lipid; Systems biology; Transport; GLTP; Biomolecular networks; GPL; PS; PITP; GM2A; SCP2; Signaling lipid; OSBP; Biological membranes; TSPO; Non-vesicular lipid trafficking; ML; GEF; Metabolism; Membrane contact sites; ER; Organelles; GLs; GLTPD1; Lipid-transfer proteins; PITPNM1; GAP; TGN; CERT; Transport; LTD; PPARD; NPC; CETP; RARΑ; LTP; FFAT; NLS; StAR; SL; OSBPL9; FABP; PLEKHA8; PC; VAPA; Lipid-binding domains; Systems biology; PIP; PH; PI; START; MCS; OSBPL1A; PM

Within the eukaryotic cell, more than 1000 species of lipids define a series of membranes essential for cell function. Tightly controlled systems of lipid transport underlie the proper spatiotemporal distribution of membrane lipids, the coordination of spatially separated lipid metabolic pathways, a...