Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2

• Published in: Biomolecules (Basel, Switzerland) Vol. 12; no. 5; p. 631
• Main Authors: Goh, Gerard Kian-Meng, Dunker, A Keith, Foster, James A, Uversky, Vladimir N
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2022; MDPI
• Subjects: Animals; Artificial intelligence; Bronchus; Chiroptera; coronavirus; Coronaviruses; COVID-19; Dengue fever; Disease transmission; Ebola virus; intrinsic disorder; membrane; Mucosa; Mutation; Neural networks; nucleocapsid; nucleoprotein; Pandemics; Phylogenetics; Phylogeny; Proteins; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Virions; Virulence; Viruses; China; membrane; nucleoprotein; coronavirus; mucus; severe acute respiratory syndrome; spread; COVID-19; lung; nucleocapsid; saliva; bronchus; transmission; virulence; shell; pangolin; Omicron; intrinsic disorder

Before the SARS-CoV-2 Omicron variant emergence, shell disorder models (SDM) suggested that an attenuated precursor from pangolins may have entered humans in 2017 or earlier. This was based on a shell disorder analysis of SARS-CoV-1/2 and pangolin-Cov-2017. The SDM suggests that Omicron is attenuate...