Heterozygous Ldlr-Deficient Hamster as a Model to Evaluate the Efficacy of PCSK9 Antibody in Hyperlipidemia and Atherosclerosis - Wu, Yue; Xu, Ming-Jiang; Cao, Zhiyou; Yang, Chun; Wang, Jinjie; Wang, Bijue; Liu, Jian; Wang, Yuhui; Xian, Xunde; Zhang, Fang; Liu, George; Chen, Xiaoli (International journal of molecular sciences, 2019)
Keywords: Abdomen; Animals; Antibodies; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - pharmacology; Atherosclerosis; Atherosclerosis - chemically induced; Atherosclerosis - drug therapy; Atherosclerosis - genetics; Cardiovascular disease; Cholesterol; Cholesterol, LDL - blood; Coronary vessels; Correlation analysis; Cricetinae; Diet, High-Fat - adverse effects; Disease Models, Animal; Ezetimibe - administration & dosage; Ezetimibe - pharmacology; Heterozygote; Humans; Hyperlipidemias - chemically induced; Hyperlipidemias - drug therapy; Hyperlipidemias - genetics; Lipids; Lipoproteins; Male; Metabolic disorders; Metabolism; Mutation; Plasma; Proprotein Convertase 9 - antagonists & inhibitors; Proteins; Receptors, LDL - deficiency; Treatment Outcome; Triglycerides; atherosclerosis; proprotein convertase subtilisin/kexin type 9; low-density lipoprotein receptor; animal model; dyslipidemia; low-density lipoprotein