The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 11; p. 1639
• Main Authors: Kawagoe, Fumihiro, Mototani, Sayuri, Kittaka, Atsushi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.11.2021; MDPI
• Subjects: Alcohol; Animals; Cholecalciferol - chemistry; D-ring modification; Fluorides; Humans; Melanoma; Naphthalenes - chemistry; Oxidation; Review; Skin cancer; structure-activity relationship; synthesis; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - chemical synthesis; Vitamin D - chemistry; Vitamin D - pharmacology; Vitamin D3; synthesis; structure-activity relationship; D-ring modification; vitamin D3

The vitamin D structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D . Many efforts have been made to date to assess the possible clinical use of vitamin D. So...