TIM-1 As a Signal Receptor Triggers Dengue Virus-Induced Autophagy

• Published in: International journal of molecular sciences Vol. 20; no. 19; p. 4893
• Main Authors: Chu, Li-Wei, Yang, Chia-Jui, Peng, Kuan-Jen, Chen, Pei-Ling, Wang, Shuu-Jiun, Ping, Yueh-Hsin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 02.10.2019; MDPI
• Subjects: Antibodies; Autophagosomes - metabolism; Autophagy; Binding sites; Biomarkers; Cell Line; Dengue - metabolism; Dengue - virology; Dengue fever; Dengue Virus; Flow cytometry; Gene Knockdown Techniques; Genomes; Hepatitis A; Hepatitis A Virus Cellular Receptor 1 - metabolism; Humans; Immunoglobulins; Infections; Kinases; Models, Biological; Pathogens; Proteins; Roles; Signal Transduction; Viral infections; Virus Replication; Viruses; West Nile virus; early endosome; autophagy; p85; TIM-1; dengue virus; rab5

Dengue virus (DENV) infection triggers the activation of autophagy to facilitate the viral replication cycle from various aspects. Although a number of stimulators are proposed to activate autophagy, none of them appears prior to the uncoating process. Given that T-cell immunoglobulin and mucin doma...