A Role for Caveolin-3 in the Pathogenesis of Muscular Dystrophies

• Published in: International journal of molecular sciences Vol. 21; no. 22; p. 8736
• Main Authors: Pradhan, Bhola Shankar, Prószyński, Tomasz J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.11.2020; MDPI
• Subjects: Adipocytes; Animals; Arrhythmias, Cardiac - genetics; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - physiopathology; Arteriosclerosis; Atherosclerosis; Autophagy; Cardiac muscle; Cardiomegaly - genetics; Cardiomegaly - metabolism; Cardiomegaly - physiopathology; Cardiovascular diseases; Caveolae; Caveolae - metabolism; Caveolin; Caveolin 3 - chemistry; Caveolin 3 - genetics; Caveolin 3 - metabolism; Caveolin-3; Cell surface; Cholesterol; Diabetes mellitus; Dystrophin - genetics; Dystrophin - metabolism; endocytic pathway; Endocytosis; Endothelial cells; Energy metabolism; Epithelial cells; Fibroblasts; Gene Expression Regulation; Growth factors; Homeostasis; Humans; Invaginations; Kinases; Lipid metabolism; Lipids; Mechanotransduction; Mechanotransduction, Cellular; Membranes; Mice; Mice, Inbred mdx; Mitochondria; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Muscles; Muscular Dystrophies - genetics; Muscular Dystrophies - metabolism; Muscular Dystrophies - physiopathology; Muscular dystrophy; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neuromuscular Junction - genetics; Neuromuscular Junction - metabolism; Neuromuscular Junction - physiopathology; Oligomerization; Pathogenesis; Plasma; Potassium Channels, Tandem Pore Domain - genetics; Potassium Channels, Tandem Pore Domain - metabolism; Proteins; Receptors, Adrenergic, beta - genetics; Receptors, Adrenergic, beta - metabolism; Review; scaffolding domain; Signal transduction; Skeletal muscle; muscular dystrophy; scaffolding domain; Caveolin-3; cardiovascular diseases; dystroglycan; dystrophin; endocytic pathway; caveolae

Caveolae are the cholesterol-rich small invaginations of the plasma membrane present in many cell types including adipocytes, endothelial cells, epithelial cells, fibroblasts, smooth muscles, skeletal muscles and cardiac muscles. They serve as specialized platforms for many signaling molecules and r...