Genetic and clinical risk factors of new-onset diabetes after transplantation in Hispanic kidney transplant recipients
New-onset diabetes after transplantation (NODAT) is one of the major complications after transplantation and is associated with reduced overall patient and graft survival. The objective of this study was to determine the genetic and clinical risk factors for NODAT in Hispanic kidney transplant recip...
Saved in:
Published in | Transplantation Vol. 91; no. 10; p. 1114 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
27.05.2011
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | New-onset diabetes after transplantation (NODAT) is one of the major complications after transplantation and is associated with reduced overall patient and graft survival. The objective of this study was to determine the genetic and clinical risk factors for NODAT in Hispanic kidney transplant recipients.
Hispanic kidney allograft recipients without evidence of preexisting diabetes who developed NODAT (n=133) were studied using Hispanic kidney transplant recipients with no evidence of diabetes as a control group (n=170). NODAT was defined as fasting glucose levels ≥126 mg/dL on two or more occasions or patients taking any insulin or oral hypoglycemic agents 1 month or later after kidney transplantation. Fourteen alleles in nine genes were genotyped and other patients' clinical data with genotype data were analyzed by logistic regression.
Among 14 alleles, hepatocyte nuclear factor 4 alpha (HNF4A) AA (rs2144908, odds ratio [OR]=1.96, confidence interval [CI]=1.08-3.50, P=0.010), HNF4A TT (rs1884614, OR=2.44, CI=1.42-4.48, P=0.002), and insulin receptor substrate 1 AA+AG (rs1801278, OR=2.71, CI=1.16-6.89, P=0.021) remained significant after logistic regression. Among the clinical factors, average age (OR=1.01, CI=1.00-1.08, P=0.048), sirolimus (OR=5.36, CI=3.02-10.4, P=0.001), deceased donor (OR=1.96, CI=1.16-2.94, P=0.015), and acute rejection (OR=2.92, CI=1.31-5.77, P=0.009) remained significant after logistic regression.
This study indicates that polymorphism of two alleles of HNF-4A gene (rs2144908 and rs1884614) and insulin receptor substrate 1 (rs1801278) are significantly associated with NODAT in kidney transplant patients with Hispanic ethnicity. In the case of clinical factors, older age (>50 year), deceased donor type, acute rejection, and sirolimus use are associated with NODAT in Hispanic kidney transplant recipients. |
---|---|
AbstractList | New-onset diabetes after transplantation (NODAT) is one of the major complications after transplantation and is associated with reduced overall patient and graft survival. The objective of this study was to determine the genetic and clinical risk factors for NODAT in Hispanic kidney transplant recipients.
Hispanic kidney allograft recipients without evidence of preexisting diabetes who developed NODAT (n=133) were studied using Hispanic kidney transplant recipients with no evidence of diabetes as a control group (n=170). NODAT was defined as fasting glucose levels ≥126 mg/dL on two or more occasions or patients taking any insulin or oral hypoglycemic agents 1 month or later after kidney transplantation. Fourteen alleles in nine genes were genotyped and other patients' clinical data with genotype data were analyzed by logistic regression.
Among 14 alleles, hepatocyte nuclear factor 4 alpha (HNF4A) AA (rs2144908, odds ratio [OR]=1.96, confidence interval [CI]=1.08-3.50, P=0.010), HNF4A TT (rs1884614, OR=2.44, CI=1.42-4.48, P=0.002), and insulin receptor substrate 1 AA+AG (rs1801278, OR=2.71, CI=1.16-6.89, P=0.021) remained significant after logistic regression. Among the clinical factors, average age (OR=1.01, CI=1.00-1.08, P=0.048), sirolimus (OR=5.36, CI=3.02-10.4, P=0.001), deceased donor (OR=1.96, CI=1.16-2.94, P=0.015), and acute rejection (OR=2.92, CI=1.31-5.77, P=0.009) remained significant after logistic regression.
This study indicates that polymorphism of two alleles of HNF-4A gene (rs2144908 and rs1884614) and insulin receptor substrate 1 (rs1801278) are significantly associated with NODAT in kidney transplant patients with Hispanic ethnicity. In the case of clinical factors, older age (>50 year), deceased donor type, acute rejection, and sirolimus use are associated with NODAT in Hispanic kidney transplant recipients. |
Author | Hutchinson, Ian I Shah, Tariq Yang, Jaewook Min, David I |
Author_xml | – sequence: 1 givenname: Jaewook surname: Yang fullname: Yang, Jaewook email: jyang2@kumc.edu organization: Department of Pharmacy Practice, School of Pharmacy, University of Kansas, Kansas City, KS, USA. jyang2@kumc.edu – sequence: 2 givenname: Ian I surname: Hutchinson fullname: Hutchinson, Ian I – sequence: 3 givenname: Tariq surname: Shah fullname: Shah, Tariq – sequence: 4 givenname: David I surname: Min fullname: Min, David I |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21544032$$D View this record in MEDLINE/PubMed |
BookMark | eNpNkMtKw0AUQAdR7EO_QJD5gdQ7jySTpRRthYIbXZebmzswNp2EzKj07xVUcHU2h7M4C3Eeh8hC3ChYKWjquzyuoAVl2CinVaXBN2dirkpjiwoczMQipTcAKE1dX4qZVqW1YPRcfGw4cg4kMXaS-hADYS-nkA7SI-VhSnLwMvJnMcTEWXYBW86cJPrMk8wTxjT2GDPmMEQZotyGNOJ3Rh5CF_n0T5ETUxgDx5yuxIXHPvH1L5fi9fHhZb0tds-bp_X9riBbu1w0DVqgCj062_oOlaeKyFgHnpuayqZkch3WzhG5hqBUWjkwrNHVLVOpl-L2pzu-t0fu9uMUjjid9n8D9BeKKmIV |
CitedBy_id | crossref_primary_10_1111_1753_0407_12853 crossref_primary_10_1111_liv_12706 crossref_primary_10_1016_j_trre_2013_12_004 crossref_primary_10_1016_j_metabol_2016_07_011 crossref_primary_10_1111_petr_12690 crossref_primary_10_1210_er_2015_1084 crossref_primary_10_3390_transplantology2040042 crossref_primary_10_1002_lt_26219 crossref_primary_10_1210_endrev_bnab010 crossref_primary_10_3390_ijms22073422 crossref_primary_10_1097_TP_0000000000000978 crossref_primary_10_1111_1753_0407_12275 crossref_primary_10_1007_s00228_012_1292_8 crossref_primary_10_1007_s00439_011_1092_8 crossref_primary_10_1097_TP_0b013e31824db97d crossref_primary_10_2337_db13_0106 crossref_primary_10_4093_dmj_2012_36_3_199 crossref_primary_10_15825_1995_1191_2018_1_127_137 crossref_primary_10_1038_tpj_2017_1 crossref_primary_10_3389_fmed_2023_1168967 crossref_primary_10_1210_endrev_bnaa030 crossref_primary_10_1016_j_bbacli_2015_12_004 crossref_primary_10_1111_jdi_13317 crossref_primary_10_1371_journal_pone_0147323 crossref_primary_10_3390_jpm13121706 crossref_primary_10_1111_ctr_12103 crossref_primary_10_2217_pgs_15_169 crossref_primary_10_1016_j_transproceed_2021_09_031 crossref_primary_10_2337_dc11_1230 crossref_primary_10_1007_s40262_013_0120_3 crossref_primary_10_1007_s11033_014_3483_0 crossref_primary_10_1681_ASN_2013040383 crossref_primary_10_1016_j_ymgme_2011_12_020 crossref_primary_10_3390_genes15040503 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.1097/tp.0b013e31821620f9 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1534-6080 |
ExternalDocumentID | 21544032 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Los Angeles |
GeographicLocations_xml | – name: Los Angeles |
GroupedDBID | --- -~X .-D .55 .XZ .Z2 01R 0R~ 123 1J1 40H 4Q1 4Q2 4Q3 53G 5RE 5VS 77Y 7O~ AAAAV AAAXR AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AARTV AASOK AAUEB AAXQO AAYEP ABBUW ABDIG ABJNI ABOCM ABPPZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACWDW ACWRI ACXNZ ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFDTB AFEXH AFFNX AFUWQ AGINI AHOMT AHQNM AHRYX AHVBC AIJEX AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS AMJPA AMNEI AWKKM BOYCO BQLVK C45 CGR CS3 CUY CVF DIWNM DU5 DUNZO E.X EBS ECM EIF EJD EX3 F2K F2L F2M F2N F5P FCALG FL- FW0 H0~ HZ~ IH2 IKREB IKYAY IN~ J5H JK3 JK8 K8S KD2 KMI L-C L7B N9A NPM N~7 N~B O9- OAG OAH ODA ODMTH OHYEH OJAPA OL1 OLG OLH OLU OLV OLW OLY OLZ OPUJH OUVQU OVD OVDNE OVIDH OVLEI OVOZU OWV OWW OWY OWZ OXXIT P2P RLZ S4R S4S TEORI V2I VVN W3M WOQ WOW X3V X3W X7M XYM YFH YOC ZFV ZZMQN |
ID | FETCH-LOGICAL-c478t-99a40c6afa84bfda1fc6cc3480fe97c595ec8da788cc89c05121803e2a87bec52 |
IngestDate | Sat Sep 28 08:00:31 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c478t-99a40c6afa84bfda1fc6cc3480fe97c595ec8da788cc89c05121803e2a87bec52 |
OpenAccessLink | https://doi.org/10.1097/tp.0b013e31821620f9 |
PMID | 21544032 |
ParticipantIDs | pubmed_primary_21544032 |
PublicationCentury | 2000 |
PublicationDate | 2011-05-27 |
PublicationDateYYYYMMDD | 2011-05-27 |
PublicationDate_xml | – month: 05 year: 2011 text: 2011-05-27 day: 27 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Transplantation |
PublicationTitleAlternate | Transplantation |
PublicationYear | 2011 |
SSID | ssj0005377 |
Score | 2.2451565 |
Snippet | New-onset diabetes after transplantation (NODAT) is one of the major complications after transplantation and is associated with reduced overall patient and... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 1114 |
SubjectTerms | Adult Age Factors Case-Control Studies Chi-Square Distribution Diabetes Mellitus - ethnology Diabetes Mellitus - genetics Female Gene Frequency Genetic Predisposition to Disease Graft Rejection - ethnology Graft Rejection - genetics Hepatocyte Nuclear Factor 4 - genetics Hispanic Americans - genetics Humans Immunosuppressive Agents - adverse effects Insulin Receptor Substrate Proteins - genetics Kidney Transplantation - ethnology Logistic Models Los Angeles Male Middle Aged Odds Ratio Polymorphism, Genetic Retrospective Studies Risk Assessment Risk Factors Sirolimus - adverse effects Time Factors Tissue Donors - statistics & numerical data Transplantation, Homologous Treatment Outcome |
Title | Genetic and clinical risk factors of new-onset diabetes after transplantation in Hispanic kidney transplant recipients |
URI | https://www.ncbi.nlm.nih.gov/pubmed/21544032 |
Volume | 91 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYWKlVcEI-WUqCaQ8UFhYas48cRIRBCgtMicUOOH-oKyC5SCqK_oz-4YztOtqulor0kUWxZq8yXL-PZmW8I-WqsK4cFl1lJqyqjgll85zTLbCGqyglamBBwu7xi59f04qa8GQx-zWQt_WiqQ_1zYV3J_1gV76FdfZXsP1i2WxRv4DXaF49oYTy-ycZeMzoJrnYljiFZPLXR8Wka9jnzKdNNH2eNjcGboGt-r-o24dCrXo2RYHxLnLuxqZEt-ikHXgVjOk7KT8mfHf25RschbRT6Qtnn5MUH7DQ-dTOVmyG19K2Zv6sQ4Bnh3v2xQ0EUOAh59-1U00dcfZVb_L4kUqUZy2PHpsS6sUdXQlc-w6HIvnQhuUfR4GbaB2-LI1bkTs7ORgtNH4K9Cy80lMfo6d9H5xS309ASWeLCs-aVjwCltKEh50m9SvJvC35N0JeOK8ztVYLPMlojq-1mA44jctbJwNYbZPO4Vs3k4QX2IaT_hv9VNsj7yzbLYpM8tbgCxBUkXIHHFbS4gomDDleQcAUBVzCHKxjXkHAFEVczU6DH1QdyfXY6OjnP2v4cmaZcNJmUiuaaKacErZxRR04zrYdU5M5KrktZWi2M4kJoLaRG-kd_Mh_aQgmO1FEWH8lyPantJwI4zpivJzLowJdUS1EahZ8TafDEhdsmW_FB3k6jCMttesSfXx3ZISs9HHfJO4dvvd1DF7KpvgSb_gaOMXWl |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+and+clinical+risk+factors+of+new-onset+diabetes+after+transplantation+in+Hispanic+kidney+transplant+recipients&rft.jtitle=Transplantation&rft.au=Yang%2C+Jaewook&rft.au=Hutchinson%2C+Ian+I&rft.au=Shah%2C+Tariq&rft.au=Min%2C+David+I&rft.date=2011-05-27&rft.eissn=1534-6080&rft.volume=91&rft.issue=10&rft.spage=1114&rft_id=info:doi/10.1097%2Ftp.0b013e31821620f9&rft_id=info%3Apmid%2F21544032&rft_id=info%3Apmid%2F21544032&rft.externalDocID=21544032 |