An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features
Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important...
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| Published in | Biological psychiatry (1969) Vol. 97; no. 3; pp. 217 - 226 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.02.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-3223 1873-2402 1873-2402 |
| DOI | 10.1016/j.biopsych.2024.07.017 |
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| Abstract | Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses. |
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| AbstractList | Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses. Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses.Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for major depressive disorder based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses. ABSTRACTMajor depressive disorder (MDD) is a common psychiatric disorder and has been a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system (CNS), both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of MDD including blood-brain barrier (BBB) integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. Here, we comprehensively summarize an astroglial basis for MDD based on molecular, cellular, and circuit properties, suggesting that astrocytes appear to be highly sensitive to stress and are likely to be uniquely positioned to integrate peripheral and central stress responses. |
| Author | Ren, Jing Cao, Xiong Lu, Cheng-Lin |
| Author_xml | – sequence: 1 givenname: Cheng-Lin surname: Lu fullname: Lu, Cheng-Lin organization: Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China – sequence: 2 givenname: Jing surname: Ren fullname: Ren, Jing organization: Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China – sequence: 3 givenname: Xiong surname: Cao fullname: Cao, Xiong email: caoxiong@smu.edu.cn organization: Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39084500$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_adhm_202402219 crossref_primary_10_3748_wjg_v30_i48_5104 crossref_primary_10_3389_fnana_2025_1457557 crossref_primary_10_3390_neuroglia6020015 crossref_primary_10_1038_s41467_025_57924_1 crossref_primary_10_3390_brainsci14100973 crossref_primary_10_1016_j_biopsych_2024_08_017 |
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| Keywords | Brainwide network Astrocyte-neuron crosstalk Astrocyte network Astrocytes Major depressive disorder Stress glucocorticoid receptor KYNA Resting-state functional connectivity BBB basic fibroblast growth factor CUMS quinolinic acid Brain-wide network glial-derived neurotrophic factor kynurenine rsFC MDD PFC locus coeruleus S100 calcium-binding protein B purinergic receptor P2X TRP Cx hypothalamus-pituitary-adrenal purinergic ligand-gated ion channel 7 receptor P2X2 brain-derived neurotrophic factor S100β lateral habenula KYN O-GlcNAc transferase hamilton depression scale monocarboxylate transporter 4 connexins bFGF ligand-gated ion channel 2 NOD-like receptor thermal protein domain associated protein cerebrospinal fluid HPA GPCR inositol 1,4,5-trisphosphate receptor glial fibrillary acidic protein kynurenic acid chronic unpredictable mild stress IP3R CRS prefrontal cortex chronic social defeat stress 3-HK P2X7R MCT4 rsfMRI glutamate transporter-1 CSF NLRP Resting-state functional magnetic resonance imaging tryptophan blood-brain barrier CSDS G protein-coupled receptor ACC Anterior cingulate cortex BDNF LHb chronic restraint stress GR GFAP QUIN 3-hydroxykynurenine HAMD GDNF LC OGT GLT-1 |
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| Snippet | Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the... ABSTRACTMajor depressive disorder (MDD) is a common psychiatric disorder and has been a leading cause of disability worldwide. Astrocytes play a role in the... |
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| SubjectTerms | Animals Astrocyte network Astrocyte-neuron crosstalk Astrocytes Astrocytes - metabolism Astrocytes - pathology Blood-Brain Barrier - metabolism Brain - metabolism Brain - pathology Brain - physiopathology Brainwide network Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology Glutamic Acid - metabolism Humans Major depressive disorder Psychiatric/Mental Health Stress |
| Title | An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features |
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