Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model

• Published in: Clinical infectious diseases Vol. 74; no. 11; pp. 1933 - 1950
• Main Authors: Li, Can, Chen, Yanxia, Zhao, Yan, Lung, David Christopher, Ye, Zhanhong, Song, Wenchen, Liu, Fei-Fei, Cai, Jian-Piao, Wong, Wan-Man, Yip, Cyril Chik-Yan, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Sridhar, Siddharth, Hung, Ivan Fan-Ngai, Chu, Hin, Kok, Kin-Hang, Jin, Dong-Yan, Zhang, Anna Jinxia, Yuen, Kwok-Yung
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 10.06.2022
• Subjects: Animals; Antibodies, Viral; Chemokines; COVID-19 - prevention & control; COVID-19 Vaccines - adverse effects; Cytokines; Endothelial Cells; Humans; Injections, Intravenous; Major and Commentaries; Mice; mRNA Vaccines; RNA, Messenger; SARS-CoV-2; Troponin; Vaccines, Synthetic; COVID-19; SARS-CoV-2; intravenous; mouse model; mRNA vaccine

Abstract Background Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines. The effect of inadvertent intravenous injection of this vaccine on the heart is unknown. Methods We compared the clinical manifestations, histop...