The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD

• Published in: International journal of chronic obstructive pulmonary disease Vol. 16; pp. 2503 - 2513
• Main Authors: Che, Li, Yu, Chao, Chen, Guangshu, Lin, Jiaxin, Xie, Zhefan, Xia, Tingting, Luo, Wenzhi, Cai, Xingdong, Liu, Shengming
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Ltd 01.01.2021; Dove; Dove Medical Press
• Subjects: Bioinformatics; Chronic obstructive pulmonary disease; Cytokines; Datasets; Epithelial Cells; Gene expression; Humans; Hypoxia; il-1β; il-8; Inflammation; Interleukin-8 - genetics; Lungs; Online data bases; Ontology; Original Research; p38 mapk; Proteins; Pulmonary arteries; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary hypertension; resistin-like molecule beta/relmβ; Signal Transduction; United Kingdom > UK; China; IL-1β; IL-8; p38 MAPK; resistin-like molecule beta/RELMβ; chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is associated with a complex inflammatory regulatory network. Resistin-like molecule β (RELMβ) is highly expressed in the lungs of COPD patients. We aimed to investigate the proinflammatory effect of RELMβ on airway epithelial cells in COPD. First, a GEO...