Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 1; p. 119
• Main Authors: Novoseltseva, Anastasia A, Ivanov, Nikita M, Novikov, Roman A, Tkachev, Yaroslav V, Bunin, Dmitry A, Gambaryan, Alexandra S, Tashlitsky, Vadim N, Arutyunyan, Alexander M, Kopylov, Alexey M, Zavyalova, Elena G
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2020; MDPI
• Subjects: Affinity; Annealing; Aptamers; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - pharmacology; Avian flu; Base Sequence; Circular dichroism; dna aptamer; Experiments; g-quadruplex; G-Quadruplexes; hemagglutinin; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinins; Humans; Influenza A; Influenza A virus - drug effects; Influenza A virus - genetics; Influenza A virus - metabolism; influenza virus; Influenza, Human - drug therapy; Influenza, Human - virology; NMR; Nuclear magnetic resonance; Nucleotides; Oligonucleotides; Phylogeny; Potassium; Protein Binding; Sodium; Spectroscopy; Spectrum analysis; Structure-function relationships; structure–activity relationship; Surface plasmon resonance; Viruses; Sweden; Vietnam; United Kingdom > UK; United States > US; England; Germany; Russia; influenza virus; structure–activity relationship; DNA aptamer; hemagglutinin; G-quadruplex; affinity

An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity. Among them, the DNA aptamer RHA0385 is able to...